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박윤경 ( Yun Gyoung Park ),이광혁 ( Kwang Hyuck Lee ),이종균 ( Jong Kyun Lee ),이규택 ( Kyu Taek Lee ),최동욱 ( Dong Wook Choi ),최성호 ( Seong Ho Choi ),허진석 ( Jin Seok Heo ),장기택 ( Kee Taek Jang ),이은미 ( Eun Mi Lee ),김정 대한소화기학회 2011 대한소화기학회지 Vol.58 No.4
Background/Aims: Intraductal papillary mucinous neoplasms (IPMN) are precursor lesions of fatal pancreatic cancer. Physiological function of microRNA is to regulate the stability and translation of mRNA. The aberrant microRNA expression is commonly observed in many cancers. The aim of this study was to analyze the expression pattern of microRNA in IPMN and evaluate the role of the microRNA. Methods: Using two paraffin-embedded IPMN tissues, microRNA expression of normal tissue, IPMN adenoma and carcinoma were compared by cDNA-mediated annealing, selection, extension and ligation microarray assay. Using real time PCR, expression levels of aberrantly up-regulated microRNAs were assessed in another 20 IPMNs, four pancreatic cancer cell lines (Panc1, MiaPaCa-2, XPA-3, BxPC-3) and immortalized pancreatic ductal cell line (HPNE). Effect of suppressing highly over-expressed two microRNAs in pancreatic cancer cell lines with anti-microRNA inhibitors were evaluated using CCK-8 assay. Results: Among aberrantly expressed 122 microRNAs in IPMN, miR-552, miR-25*, miR-183, miR-1300, miR-196a, miR-182*, and miR-30c-1* were consistently increased more than 3-fold. On average, miR-196a and miR-183 increased 10,824 folds and 26,519 folds in four pancreatic cancer cell lines compared with HPNE. These two microRNAs were also over-expressed in 20 IPMNs compared with HPNE. After applying anti-miRNA inhibitors, cell survival of four pancreatic cancer cell lines decreased by 24.5% with anti-miR-196a and by 14.2% with anti-miR-183 on average. Conclusions: Aberrant expression of 122 microRNAs was observed in IPMN. Two microRNAs, miR-196a and miR-183-increased in IPMN and pancreatic cancer cell lines compared with immortalized dancreatic ductal cell line. The inhibitions of these microRNAs repressed cell proliferation of pancreatic cancer cell lines. (Korean J Gastroenterol 2011;58:190-200)
증례 : 호흡기 ; 수술적 조직 검사로 증명된 미만성 폐포 손상에 의한 폐경색 1예
김은정 ( Eun Jung Kim ),김정옥 ( Jung Ok Kim ),민신영 ( Sin Young Min ),박윤경 ( Yun Gyoung Park ),박하나 ( Ha Na Park ),서지영 ( Gee Young Suh ),이경수 ( Kyung Soo Lee ) 대한내과학회 2012 대한내과학회지 Vol.82 No.4
We report a case of a 63-year-old man with adult respiratory distress syndrome and pulmonary infarction. The patient presented with fever, dyspnea, pleuritic chest pain, and acute respiratory failure, and we applied mechanical ventilation and steroid therapy. Pulmonary infarction and diffuse alveolar damage were confirmed by open-lung biopsy. Diffuse alveolar damage activated the blood coagulation system, resulting in thrombosis in the pulmonary vasculature. After anticoagulation therapy, the patient improved rapidly. We report a rare pulmonary infarction caused by diffuse alveolar damage confirmed by open-lung biopsy. (Korean J Med 2012;82:487-491)
김정옥 ( Jung Ok Kim ),김은정 ( Eun Jung Kim ),민신영 ( Shin Young Min ),박윤경 ( Yun Gyoung Park ),조아진 ( A Jin Cho,Jun ),전준석 ( Seok Jeon ),김준수 ( June Soo Kim ) 대한내과학회 2011 대한내과학회지 Vol.81 No.2
저자들은 다른 기저 질환이 없는 환자에서 발생한 기침과 동반한 방실전도차단과 관련된 기침 유발성 실신을 영구형심박동기 삽입술로 치료하였던 예를 문헌고찰과 함께 보고 하는 바이다. We report the case of a 52-year-old man who had two syncopal episodes associated with coughing. Other than essential hypertension, he had no organic disease of the heart or lungs. Transient complete atrioventricular block following coughing was detected by electrocardiographic telemonitoring while resting. During that time, the patient experienced near-syncope similar to his previous syncopal episodes. He was treated successfully with permanent pacemaker implantation. (Korean J Med 2011;81:241-244)