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Phellinus linteus, Phellinus baumii 및 Phellinus gilvus 자실체 추출물의 항암효과 비교
배재성(Jae-Sung Bae),황미현(Mi-Hyun Hwang),장광호(Kwang-Ho Jang),이만휘(Man-Hee Rhee),이근우(Keun-Woo Lee),조우식(Woo-Sik Jo),최성국(Sung-Kuk Choi),윤효인(Hyo-In Yun),임종환(Jong-Hwan Lim),김종춘(Jong-Choon Kim),박승춘(Seung-Chun Par 한국독성학회 2004 Toxicological Research Vol.20 No.1
This study was undertaken to investigate comparative anti-tumor activity of water extracts of Phellinus gilvus (PGE), Phellinus linteus (PLE), and Phellinus baumii (PBE) in vitro. The anti-tumor activity in the present study was evaluated by sulforhodamine B (SRB) and microtetrazolium (MTT) assay in terms of cell survival level. The tumor cells (sarcoma 180 and P388) were treated with PGE, PLE, and PBE (7.5, 15, and 30 mg/ml) and Doxorubicin (DOX) (0.001~10 mM). The results showed that DOX, PGE, and PLE inhibited proliferation showing a dose-dependent manner against both tumor cells. However, PBE was inhibited by the only 30 mg/ml in both cells proliferation. In conclusion, all of PGE, PLE, and PBE used in this study have shown anti-tumor activity against both sarcoma 180 and P388. Among them, PLE was the most effective in anti-tumor activity against sarcoma 180 (p<0.05) and PGE was against P388 in SRB assay. PLE, however, was against P388 (p<0.05) in MTT assay.