http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
J. S. Kong(공정식),K. Min(민경현),J. Kim(김종민),J. Kim(김지수),G. Gao(가오그),H. Park(박효신),H. H. Han(한현호),D.-W. Cho(조동우) Korean Society for Precision Engineering 2021 한국정밀공학회 학술발표대회 논문집 Vol.2021 No.11월
To treat peripheral nerve deficits, a variety of synthetic and decellularized materials with anisotropic architectures are developed due to the advantages proposed by aligned structures with respect to cell activity, migration, and directionality. Additionally, narrowing microscale topological cue has advantages on alignment and migration of cells. However, up to date, fabricating 3D hydrogel constructs composed of thin microfibers under 50 μm using mechanically weak hydrogel like low concentrated dECM bioink is challenge, unlike synthetic polymer-based fabrication. In this study, we created a microgel printing bath solution to three-dimensionally print a dECM bioink, derived from porcine nerve, as a thin microfiber. A 30 μm filament resolution of low viscosity dECM hydrogel with a neutral pH was achieved using an alginate microgel supplemented printing bath. To treat the sciatic nerve defect model of rats, 3D printed cylindrical constructs retaining bundle of dECM microfibers were used as a filler of the polycaprolacton (PCL) conduit. The total number of regenerated axons and relative gastrocnemius muscle weight ratio were comparable to those of the autologous nerve graft group. Meanwhile, the results were superior to those of the porcine decellularized nerve tissue group or the 3D printed filler only group.