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RISS 인기검색어
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- 저자 : 명보현 ( Bo Hyun Myung ) (검색결과 2 건)
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최인선(Inseon S . Choi),명보현(Bo Hyun Myung),강광원(Kwang Won Kang) 대한내과학회 2001 대한내과학회지 Vol.61 No.6
N/A Background: The asthma mortality has risen during last decades, especially in the elderly. This study was performed to investigate whether newly-developed asthma in the elderly has any difference in clinical features relating to asthma severity compared to early-onset asthma (EOA).Methods: Thirty-three asthma patients (≥60 years-old) hospitalized due to severe attack were classified to late-onset (LOA) when their asthma developed after the age of 60 and the remaining to EOA. Data obtained from their medical records were analyzed retrospectively. Results: Ten out of the 33 patients (30.3%) were LOA. Duration of asthma was significantly longer in EOA (21.6±14.8 years vs. 2.9±2.4 years, p<0.001). There were no significant differences between both groups in age, sex, atopy history (personal and familial), sinusitis, and peripheral blood eosinophils. However, EOA showed more smoking history and frequent exacerbations following URI-like symptoms (p<0.05, respectively), and higher serum total IgE level (geographic mean: 228 vs. 20 IU/mL, p<0.001). Life-threatening asthma attack was developed more frequently (89.5% vs. 40%, p<0.05), and the lung function measurements obtained just before discharge were significantly lower (FEV1/FVC: 54.8±10.1% vs. 64.6±11.7%, p<0.05) in EOA. Severity of chronic asthma was significantly more severe in EOA (moderate to severe persistent asthma: 95.6% vs. 60.0%, p<0.05). Conclusion: Many elderly asthmatics develop asthma newly in their old age. EOA is more related to atopic allergy, and seems to have more severe and long-standing asthma leading to chronic persistent airflow obstruction.(Korean J Med 61:616-622, 2001)
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증례 : 소화기 ; 전신홍반루푸스에 동반된 자가면역 간염 1예
황영준 ( Young Jun Hwang ),정홍명 ( Hong Myung Jung ),박혁 ( Hyeuk Park ),문장식 ( Jang Sik Mun ),명보현 ( Bo Hyun Myung ),김도현 ( Do Hyun Kim ),김호동 ( Ho Dong Kim ) 대한내과학회 2010 대한내과학회지 Vol.78 No.1
전신홍반루푸스 환자에서 간효소 수치의 상승이 보였을 때 예후와 치료를 위해 원인을 파악하는 것은 중요하다. 특히 루푸스 간염과 자가 면역 간염을 감별하는 것은 필요하지만 두 질병의 유사성 때문에 감별이 쉽지 않다. 현재 문맥 주위의 조각 괴사, 간세포의 rossetting, 두터운 림프구 침윤과 같은 조직학적 소견과 antiribosomal P protein 항체, anti ds DNA 항체, anti Sm 항체 등의 자가항체가 두 질병을 구별하는데 도움을 줄 수 있다고 알려져 있으나 명확한 구별법은 아직 확립되지 않은 상태이다. 따라서 향후 이에 대한 연구가 필요하다고 사료되며 본 저자는 자가 면역성 간염과 동반된 전신홍반루푸스를 진단하고 스테로이드 치료로 호전된 증례를 경험하였기에 보고하는 바이다. Autoimmune hepatitis accompanied by systemic erythematosus lupus is rare. Usually, lupus-related advanced liver involvement is indistinguishable from autoimmune hepatitis accompanied by lupus, as they share common clinical, biochemical, serological, and histological manifestations. However, each disease has its own diagnostic criteria, and they have been defined as two different categories. Therefore, distinguishing between the two diseases is important to determine the correct diagnosis and treatment. A 41-year-old woman was hospitalized with jaundice and a malar rash. The patient met the diagnostic criteria of both systemic erythematosus lupus and autoimmune hepatitis. After corticosteroid treatment, the patient`s condition improved. Therefore, we report our experience of a rare case of autoimmune hepatitis accompanied by systemic erythematosus lupus with a review of the literature. (Korean J Med 78:95-98, 2010)
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