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Histamine H2 -receptor Antagonists 투약후의 (投藥後) 몇가지 부작용에 (副作用) 대한 관찰
이상종(Sang Jong Lee),이만호(Man Ho Lee),김향(Hyang Kim),노홍기(Hong Gi Roh),오동주(Dong Joo Oh),최성규(Sung Kyu Choi) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1
N/A Discovery of histamine H2-receptor antagonists is very important for clinician. They are used widely to treat peptic ulcer. However, the widespread use of these agents and the careful surveillance of patients receiving the drug by many researchers and practitioners, have led to a large number of reports identifying possible or proven complications of treatment with them. It is intention of this problem to consider the adverse effects which has been described in association with administration of these drugs. We observed fourtysix patients with peptic ulcer, who were given H2,-receptor antagonists by month over eight weeks period. Two different groups of this studies composed of cimetidine, 800 mg a day for thirtyfour patients, and ranitidine, 300 mg a day for twelve patients, respectively. Hemograms, some liver function tests, and measurement of sex hormones were undertaken before and after the treatment. The results showed no significant differences of all laboratory tests between both groups following the treatment, aside from only a case with administration of cimetidine showing transient mild elevation of S-GOT and and S-GPT. Further long term studies of both control and treatment groups are required.
대량의 심낭액저류를 동반한 원발성 갑상선기능저하증 1 예
김영희,이만호,김향,이상종,오동주,노홍기 대한내과학회 1986 대한내과학회지 Vol.30 No.3
With application of ultrasonic techniques for noninvasive diagnosis of cardiovascular system, it has bean r-ported that pericardial effusion is observed by echocardiography in one third of patients with primary hypothyroidism. Though the mechanism of pericardial effusion in primary hypothyroidism is not well understood, the sodium and fluid retention, decreased lymphatic drainage, and leakage of albumin from blood by increased capillary permiability have been suggested as possible causes. The clinical characteristics of pericardial effusion in patients with primary hypothyroidism are that it accumulates so slowly that patient bas little hemodynamic deterioration and rarely develops cardiac tamponade. We experienced an interesting case of primary hypothyroidism with pericardial effusion, recently. The patient was a fifty sevenyear-old housewife with exartional dyspnea and general weakness. Chest X-ray showed marked cardiomegaly and electracardiogram revealed low voltage through whole leads. Both serum T3RIA and T4RIA levels were low but serum TSH level was extremely high. Echocardiography showed massive pericardial effusion, After thyroid replacement therapy for sixteen weeks, her clinical condition was not only improved, but the pericardial effusion had almost resolved.