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- 저자 : 노지윤 ( Ji Yoon Rho ) (검색결과 5 건)
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백서의 격리 폐에서 ATP와 LTC4가 저산소성 폐혈관 수축에 미치는 영향
노지윤 ( Ji Yoon Rho ),신화용 ( Hwa Yong Shin ),김현창 ( Hyun Chang Kim ),이지원 ( Ji Won Lee ),김성덕 ( Seong Deok Kim ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.4
Background: Hypoxic pulmonary vasoconstriction (HPV) is unique to pulmonary circulation but the mechanism remains elusive. Red blood cells (RBCs) are known to augment HPV and to release more ATP as oxygen content falls. Leukotrienes constrict smooth muscle and could be important for the regulation of the pulmonary circulation. Hence we hypothesized that ATP and leukotrienes are mediators of HPV produced during acute alveolar hypoxia. Methods: In forty Sprague-Dawley rats, lungs were isolated and perfused. We administered ATP (10 μM) to the ATP group (n=8), the ATP antagonist, suramin (100 μM) to the suramin group (n=8), leukotriene C4 (LTC4, 5 μg) to the LTC4 group (n=8), the LTC4 antagonist, LY171883 (20 μM) to the LY171883 group (n=8), and LTC4 (5 μg)+ATP (10 μM) to the LTC4+ATP group (n=8) during normoxic ventilation. HPV responses were induced by three hypoxic challenges for 5 minutes separated by 5 minutes of ventilation with a normoxic gas mixture. Baseline pulmonary artery pressure change after exposure to each drug and hypoxic pressor response between a period 21% normoxic gas ventilation and that of 3% hypoxic gas ventilation were measured. Results: ATP and LTC4+ATP increased baseline pulmonary artery pressures but LTC4 did not alter it. ATP did not affect hypoxic pressor response. Suramin, LY171883 and LTC4+ATP inhibited the pressor response to hypoxia. LTC4 increased hypoxic pressor response. Conclusions: In isolated rat lungs, HPV may be mediated by ATP and LTC4 appears more likely to be a modulator than a mediator of HPV. (Korean J Anesthesiol 2009;57:472∼82)
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실험연구 : 백서의 격리폐에서 Protein Kinase C가 저산소성 폐혈관 수축에 미치는 영향
김지희 ( Jee Hee Kim ),노지윤 ( Ji Yoon Rho ),신화용 ( Hwa Yong Shin ),김성덕 ( Seong Deok Kim ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.2
Background: Protein kinase C represents an important component of a signal transduction pathway that regulates vascular smooth muscle contraction. This study was performed with an inhibitor and activators of protein kinase C to determine their effects on hypoxic pulmonary vasoconstriction (HPV) in isolated rat lung model. Methods: Isolated lungs from Sprague-Dawley rats were ventilated with a normoxic gas (21%O2-5%CO2-balanced N2) and a hypoxic gas (3%O2-5%CO2-balanced N2) alternatively, and then perfused with constant pulmonary blood flow. Baseline hypoxic pressor responses (△PAP) were measured as the difference of pulmonary artery pressure between normoxic ventilation and hypoxic ventilation. After baseline △PAP had obtained, rats were randomly divided into a chelerythrine group, an phorbol 12, 13-dibutyrate (PDBu) group, and a farnesylthiotriazole (FTT) group. The different concentrations of each drug were added into the perfusate sequentially. △PAP in the different concentrations of each drug were calculated as a percentage of the △PAP in each concentration of drug to the baseline △PAP in the absence of drug (%△PAP). Results: The %△PAP of chelerythrine were 83.7 ± 19.2%, 71.5 ± 24.1% and 68.4 ± 28.3% at 0.1, 1, and 10μM, respectively (P < 0.05). The %△PAP of PDBu were 111.3 ± 10.1%, 144.4 ± 37.8% and 168.4 ± 89.1% at 20, 100, and 300 nM, respectively (P < 0.05). The % △PAP of FTT were 80.1 ± 25.1 %, 61.0 ± 17.2% and 30.1 ± 18.4% at 1, 10, and 30μM, respectively (P < 0.05). Conclusions: The results of this study suggest that regulator of protein kinase C influence HPV. (Korean J Anesthesiol 2006; 51: 222~9)
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통원수술에서 Propofol, Isoflurane 및 Enflurane 마취 후 회복의 비교
허진,김용락,노지윤 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.38 No.4
Background : Video-assisted thoracoscopic surgery (VATS) is expected to provide fast and comfortable recovery, plus an early return to normal daily activities. This study was carried out to compare the characteristics of recovery after VATS in patients anesthetized with isoflurane, enflurane or propofol. Methods : Sixty patients undergoing VATS were allocated randomly to receive propofol-N_2O, isotlurane-N_2O or enflurane-N_2O anesthesia. The time between the end of anesthesia and extubation were compared. The orientation, cooperation and degree of sedation in Numeric Rating Scale (NRS) were recorded 5, 10, 30 and 60 min after anesthesia. Recovery was also evaluated by the P-deletion test (PDT) and Digit Symbol Substitution test (DSST) 30, 60 and 120 min after anesthesia for the comparison of the recovery of cognitive and psychomotor function. Results : Early recovery was significantly (P $lt; 0.05) faster in the propofol group (orientation, corperation and degree of sedation in 10 min) when compared to the isoflurane and enflurane groups, but there was no significant difference in the other parameters of recovery. Conclusions : The authors concluded that although propofol was associated with faster emergence from anesthesia than entlurane and isoflurane after VATS, recovery of cognitive and psychomotor function were similar in the three anesthetic groups. (Korean J Anesthesiol 2000; 38: 638 ~ 644)
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부인과 수술후 Morphine 을 이용한 정맥내 자가통증조절법에서 Ketorolac 의 적정 혼합 용량
이상철,서광석,이규탁,임영진,도상환,노영진,오아영,노지윤 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.39 No.5
Background : The aim of this study was to determine an intravenous dose of ketorolac providing augmentation of analgesia and lowering adverse events for patients using postoperative intravenous patient-controlled analgesia (IV-PCA) with morphine. Methods : One hundred and ninety eight patients who underwent an elective gynecologic operation were allocated to one of seven groups (ketorolac 180 mg K6, ketorolac 150 mg+morphine 10 mg K5Ml, ketorolac 120 mg + morphine 20 mg K4M2, ketorolac 90 mg + morphine 30 mg K3M3, ketorolac 60 mg + morphine 40 mg K2M4, ketorolac 30 mg + morphine 50 mg K1M5, morphine 60 mg M6). After a loading dose of 3 ml, the PCA was started at a setting of 1 ml per demand, with a 8 minute lockout interval and 5-h limit. Results : The total PCA volume was lower in the K3M3, K2M4 and M6 groups. Visual analogue scale pain scores were higher in the K6 and M6 groups. More additional analgesics were required in the K6, KSMl, KlM5 and M6 groups. More antiemetics were required in the M6 group, although the incidence of nausea/vomiting and pruritus was similar among the groups. The sedation scores were lower in the K6 group and higher in the M6 group, 6h postoperatively; and higher in the M6 and K1M5 groups, 24 h postoperatively. Conclusions : The combination of morphine 30 mg and ketorolac 90 mg, or morphine 40 mg and ketorolac 60 mg in IV-PCA with a total volume of 60 ml, is more effective in analgesia and has less adverse events. (Korean J Anesthesiol 2000; 39: 700-705)
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