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남택근(Taek Keun Nam),박승진(Seung Jin Park),안성자(Sung Ja Ahn),정웅기(Woong Ki Chung),나병식(Byung Sig Nah) 대한방사선종양학회 1995 Radiation Oncology Journal Vol.13 No.2
Purpose : We tried to evaluate the role of conventional radiotherapy alone or with neoadjuvant chemotherapy in the hypopharyngeal cancer by retrospective analysis. Materials and Methods : Between Jul. 1985 and Sep. 1992. 42 patients of hypopharyngeal cancer were treated by conventional radiotherapy alone or combined with neoadjuvant chemotherapy. The male to female ratio was 20:1 with a median age of 58 years. Twelve patients were treated by conventional radiotherapy alone and 30 patients were treated by neoadjuvant chemotherapy and radiotherapy. Results : Seven patients were stage Ⅰ, Ⅱ and the patients with stage Ⅲ and Ⅳ were 10 and 25. respectively at the time of presentation. The overall survival and disease-specific survival rates at 24 months were 12.9% and 15.5% respectively. Two-year survival rates of stage Ⅰ+Ⅱ and Ⅲ+Ⅳ patients CR and 26 patients(62%) revealed less than CR at the end of radiotherapy and their 2-year survival rates were 31.3% and 0%, respectively(p<0.05). On univariate analysis, stage, T-stage, N-stage and treatment response were the significant prognostic factors, but only stage and treatment response were significant on multivariate analysis. Conclusion : This conventional radiotherapy alone or with neoadjuvant chemotherapy does not seem to be sufficient in the treatment of most advanced hypopharyngeal cacner. Therefore other treatment modalities such as hyperfractionation or concurrent chemoradiotherapy should be considered.
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