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Merkel 세포암양 조직 소견을 동반한 전이성 소형 신경내분비 세포암
김재왕 ( Jae Wang Kim ),김순택 ( Soon Taek Kim ),김상석 ( Sang Seok Kim ),이종주 ( Chong Ju Lee ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.6
Metastatic small cell neuroendocrine carcinomas(MSCNC) from distant sites, such as the lung, are high grade tumors with poor prognosis. Histopathologically, it is difficult to distinguish between MSCNC and Merkel cell carcinoma solely on the basis of histologic morphology, electron microscopy, and immunohistochemistry. In recent years, differential expression of cytokeratin(CK) 20 and thyroid transcription factor(TTF)-1 has been proposed as useful distinguishing features. It must be emphasized that clinical correlation(e.g. symptomatology, chest X-ray) and a combination of CK 20 and TTF-1 markers, are essential to differentiate these two disease entities. We herein present a case of MSCNC of the lung that might be misdiagnosed as Merkel cell carcinoma. (Korean J Dermatol 2003;41(6) : 714~779)
김재왕 ( Jae Wang Kim ),남상호 ( Kwang Joong Kim ),김광중 ( Chong Joo Lee ),이종주 대한피부과학회 1998 대한피부과학회지 Vol.36 No.5
Herein we report a case of subungual osteochondroma in a male patient. Although there have been several reports about cases of subungual exostosis in Korea, a case of subungual osteochondroma had not been reported until now. Osteochcndromas are clearly different disease entities from exastosis in that they have diagnostic hyaline cartilaginous caps instead of the fibrocartilages in subungual exostosis. Additioaally, subungual osteochondroma is a very rare type having an incidence rate of less than 1% among all osteochondromas. Our patient was an 18-year-old male with a solitary woody mass on his right great toe that was painfuL A surgical excisional biopsy following a nail plate avulsion showed the characteristic hyaline cattilaginous caps enclosing bony trabecula connected with the inferior cortical bone. (Korean J Dermatol 1998;36(5): 906-909)
김재왕 ( Jae Wang Kim ),김광중 ( Kwang Joong Kim ),김종민 ( Jong Min Kim ),이종주 ( Chong Ju Lee ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.5
Herein we report two cases of leukemia cutis that were responsive to oral all-tratm retinoic acid(ATRA) therapy. The two presented patients, who had been diagnosed with acute pmmyelocytic leukemia, disclosed specific lesions of leukemia cutis through histopathological examinations. Leukemia cutis due to acute promyelocytic leukemia is characterized by PML/RAR-a chimeric fusion proteins which arise from chromosomal trmslocation. This PML/RAR-a transcript can be a valuable molecular therapeutic target to systemic retinoid therapy in that ATRA induces terminal differentiation of leukemic clones and PML/RAR-a transcript preserves the ATRA-responsive signal transduction pathway. We concluded that leukemia cutis might be treated by tretinoin therapy without notifi.able adverse effects. (Korean J Dermatol 19%;36(5): 901-905)
김재왕 ( Jae Wang Kim ),김광중 ( Kwang Joong Kim ),이종주 ( Chong Ju Lee ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.3
We herein report a case of Spitz nevus which occurred in a 6-year-old girl with acute lymphocytic leukemia. The lesion was a well delimited, symmetric, 1.0 * 1.0cm sized, dome-shaped light pinkish nodule with a shiny surface on her forehead. The histopathological findings of the excisional biopsy specimen revealed mild epidermal hyperplasia ; numerous uniform nests of spindle cells and epitheloid cells with sparce pigmentation along the dermoepidermal junction; colloid body-like eosinophilic globules ; multinucleated giant nevus cells in the epidermis and edema in the upper dermis. Since the complete excision of her lesion was accomplished, there have been no new lesions over the past year. (Korean J Dermatol 1998;36(3) - 487-492)
김재왕 ( Jae Wang Kim ),김광중 ( Kwang Joong Kim ),김종민 ( Chong Min Kim ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.1
We report herein two cases of leukemia cutis. One case is a 54-year-old woman who came to our department with complaints of a solitary ulcerating nodule on her left leg that had been present for 2 months since prior to her visit. Through histopathological studies, the diagnosis of myelocytic leukemia cutis was made before the final diagnosis of acute myelocytic leukemia was made by hematological studies. When combined chemotherapy was finished, she was in a partial remission state and the nodule disappeared after 1 month of chemotherapy. The other case is a 77-year-old man having multiple infiltrative nodules on the right forearm and right thigh for 1 month prior his visit. He was diagnosed as having leukemia cutis for his skin lesions histopathologically. This was redefined as chronic myelomonocytic leukemia of the myelodysplastic syndrome with blastic transfor- mation by hematological examination. He developed septicemia and died 3 weeks after the dermato- logical diagnosis. (Korean J Dermatol '1998;36(1): 133-138)
김재왕 ( Jae Wang Kim ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.2
A gradual increase of symptomatic syphilis in youngsters has been reported in the last few years. Although most cases of syphilis in childhood result from congenital syphilis, acquired syphilis in children may occur. Transmission of syphilis to children is usually related to sexual abuse. However, children may acquire syphilis by non-venereal contact. Acquired syphilis in a child has rarely been described in the current medical literature. Herein, we present a case of acquired secondary syphilis occurring in a 10-year-old girl in which non-sexual transmission is likely. (Korean J Dermatol 2011; 49(2):159~163)