뇌성마비(腦性痲痺)의 한의학적(韓醫學的) 접근(接近)에 관한 최신(最新) 동향(動向)

김장현,한윤정,Kim, Jang-Hyun,Han, Yun-Jeong 대한한방소아과학회 2003 대한한방소아과학회지 Vol.17 No.2

Back ground : Cerebral palsy(CP) is a static encephalopathy caused by an insult to the brain during the prenatal, perinatal, or postnatal period (ie, up to 2 years). CP can lead to global dysfunction but always includes motor problems Objective : The purpose of this study is to investigate the current tendency of oriental approach to the CP and promote oriental treatment of CP in Korea Method : Investigation of current literature and clinical paper in Korea and Chinese Result and Conclusion : 1) CP fall under the category of wu-chi(five kinds of retardations : 五遲), wu-ruan(five kinds of flaccidity : 五軟), wu-ying(five kinds of Stiffness : 五硬) in oriental medicine and correspond to naoxing-tanhuan in current chinese medicine. 2) CP is mainly caused by weakness of the liver and kidney(肝腎不足), weakness of the spleen and stomach(脾胃虛弱), and the method of treatment is tonify the liver and kidney(補益肝腎), tonify the spleen and replenish qi(補脾益氣), but yu-chi(the faculty of speech : 語遲) is caused by deficiency of the heart(心虛) so that treated with method of invigorating the heart and nourishing blood(補心養血). Recently blood stagnancy the stagnation of qi(氣滯血瘀) is considered as the cause of CP, promoting qi circulation to invigorate blood(行氣活血) is mentioned the treatment of method. 3) In addtion to a herbal medication and acupuncture, the various treatments of scalp acupuncture(頭鍼), acupoint injection(穴位注射), catgut embedding therapy(埋鍼) etc. had been applicated to CP and for the objective evaluation of remedial value, TCD, EEG, BMD have been used.

전산화(電算化) 진단(診斷)의 Database 구축을 위한 소아(小兒) 관형찰색(觀形察色)에 관한 연구(硏究)

김장현,Kim Jang-Hyun 대한한방소아과학회 2001 대한한방소아과학회지 Vol.15 No.1

In oriental medicine, diagnostic method was the four examination(四診) which was composed of inspection(望診), inquiring(問診), listening and smelling(聞診), palpation(切診). Inspection of skin color(望色) indicated the observation of patient's complexion(色診). In oriental medical theory, complexion of face was related to meridians(經絡) and zang-fu(贓腑). The change of complexion was reflected the ups and downs of qi(氣) and blood(血), the relative seriousness of an illness. especially, observation of complexion was essential in children, because of diagnostic difficulty and positive change according to each disease. The purpose of this study was to construct for standard measurement and invent for computerizing diagnostic system which was based on observation of complexion. It was objectively measured complexion using spectrophotometer and chroma meter. Measurement of complexion should make an offer the index of diagnosis.

성장장애(成長障碍)에 관(關)한 임상적(臨床的) 연구(硏究)(I)

김장현,Kim Jang-Hyun 대한한방소아과학회 1998 대한한방소아과학회지 Vol.12 No.1

I intended to be helpful to understand significant cause for treated patients comed to Dept of Pediatrics growth clinic in short stature of delayed growth and effect of oriental medical therapy. I studied at first 54 patients(36 men and 18 women) comed to Dept. of Pediatrics growth clinic of Dongguk Pundang Oriental Hospital and investigated characteristics, remidial value and side effect which 20 patients(1l men and 9 women) treated oriental medical therapy in short stature of delayed growth between June 1997 and October 1998. First study resulted the average was 8.37 year(chronological age), 6.96 year(bone age), 15.43 (height percentile by age), 164.2 cm(mid parental height) and the ratio of using the prescription was Bojunggunatang-derivative at first. second study resulted the distribusions of remedial values were improved(55.0%) and no improved(45.0%) patients. remedial values was affected by appetite.

국방 M&S체계 소프트웨어 비용 추청모델 개발에 관한 연구

김장현,정층영,Kim, Jang-Hyun,Jung, Choong-Young 한국국방경영분석학회 2010 한국국방경영분석학회지 Vol.36 No.3

Since the mid-nineties, Republic of Korean Army has officially adapted information technology. Starting with the Chang-Jo 21('99) training M&S Model, around seventy types of the M&S system software, including Ground Operations & Resources Requirement Analysis Model ('10), developed by Republic of Korea Army or foreign counterparts have been utilized. However, as the existing cost estimations of the Defense M&S system software fail to reflect the acquisition and development environment, the estimated costs have been frequently overestimated or underestimated. This paper provides a suitable cost estimation model for the Defense M&S system software by presenting the software cost drivers which reflect the unique software development environment of the Defense.

새로운 인간(人間) 태반(胎盤)유래의 항응고(抗凝固) 단백질(蛋白質) PP27 (annexin Ⅴ형(型) 단백질(蛋白質))의 정제(精製)와 특성(特性)

김장현,Kim Jang-Hyun 대한한방소아과학회 2000 대한한방소아과학회지 Vol.14 No.2

It has long been known that Jahage(紫河車) extracts of Placenta hominis are effective for immunological and vascular diseases in human body and thus, was used a major constituent of traditional oriental medicines. From full-term human placenta, we have purified a new type anticoagulant protein, PP27, using different chromatographic techniques of a phenyl TSK gel 650M column, DEAE, HA and Mono-Q columns. PP27 showed single band on SDS-PAGE with a molecular mass (Mr) of 27 kDa under denaturing conditions and a calibrated Sepharose 4B column chromatography indicated a molecular mass of 23 kDa, indicating that the value is similar to those of other PP4 enzyme reported to date. Isoelectric point of PP27 was p15.2. The protein was found to inhibit the coagulation time in a concentration-dependent manner. PP27 was acted as a vascular anticoagulant of annexin type, inhibits the blood clotting process by binding of the essential lipids in a reaction which is dependent on $Ca2^+$ ions. In the presence of $Ca2^+$ ions, PP27 combines with platelet membranes neutralizing their procoagulant effect. Coagulation triggered by the addition of thromboplastin/ lipid- mixtures is extinguished by PP27.

소아설사(小兒泄瀉)에 대한 가감전씨백출산(加減錢氏白朮散)의 임상효능(臨床效能)에 관한 연구(硏究)

김장현,Kim, Jang-Hyun 대한한방소아과학회 2004 대한한방소아과학회지 Vol.18 No.2

Objectives: The objective of this study is to assess the clinical effect of Gagamjeonsibaekchulsan on child diarrhea. Methods: This clinical study was carried out with 42 cases(31male, 11female) of children aged 0 to 14 years old who visited the Department of Pediatrics, Dongguk University Bundang Oriental Hospital and were diagnosed as the diarrhea. Assessments were made with reference to sex, age, the duration of symptoms and physical history. To assess the impact of Gagamjeonsibaekchulsan, the complicated signs, the duration of treatment, the correlation between the use of Gagamjeonsibaekchul- san and the duration of symptom were examined before and after the treatment. Results: There were 31 males and 11 females in the incidence by sex. It showed that males were more than females. The most numerous age group was 0-2(19) followed by 3-7 (11) and 9-12 (12). According to the duration of symptom, 12 children have symptom for 0-7 days, 10 for 8-14 days, 11 for 15-20 days, 4 for 22-28 days and 5 over 28 days. With regard to the physical history of the sample, 5 children had atopic dermatitis, 3 children had enteritis, 3 children had rhinitis, 2 children had tonsillitis, 1 child had otitis media, 1 child had asthma and 1 child had pneumonia. The children also had the complicated signs: 22 children had anorexia, 17 children had abdominal pain, 13 children had vomiting and 8 children had nausea in digestive organ. In addition 11 children had dizziness, 7 children had general weakness, 1 child had enuresis and 1 child had sweat in general symptoms. For the duration of the treatment, 14 children were treated for 7 days, 13 for 8-10 days, 8 for 11-14 days, 3 for 15-21 days, 2 for 22-28 days and 2 for 29-40 days. No distinct relationship between the use of Gagamjeonsibaekchul-san and the duration of the symptom was found. Conclusion: Gagamjeonsibaeichul-san is effective in the treatment of intestine mucous membrane and improves the function of digestive system. It is also an effective short-term treatment for child diarrhea.

대방풍탕(大防風湯)이 galactosamine으로 유도(誘導)한 간중독(肝中毒) 흰쥐에 미치는 영향(影響)

김장현,Kim Jang-Hyun 대한한방소아과학회 1997 대한한방소아과학회지 Vol.11 No.1

In order to study the effects of Daebangpungtang on galactosamine induced hepatoxity in rats, the experimental rats divided five groups (Normal, Control, Sample A, B, C groups). Under the same condition, normal and control groups were administered normal saline for 16 days, control group was injected to abdomen with galactosamine at 8th day (800mg/kg). Sample A group was administered the Daebangpungtang aqueous solution($200m{\ell}/kg$ p.o) for 8 days and injected galactosamine(800mg/kg i.p) for the last day and was administered normal saline for 8 days. Sample B group was treated as same as group A for 8 days, and then was administered the Daebangpungtang aqueous solution($200m{\ell}/kg$ p.o) forfurther 8 days. Sample C group was administered the Daebangpungtang aqueous solution($200m{\ell}/kg$ p.o) for 16 days. The activity of GOT, GPT, ${\gamma}$-GTP, ALP, LDH and total bilirubin in serum were measured at 8th and last day. The results were obtained as follows: 1. The activity of serum GOT of the sample A group decreased effectively at the 8th day and sample B group decreased effectively at 16th day as compared with the control group. 2. The activity of serum GPT of the sample A group decreased effectively at the 8th and 16th day and sample B group decreased effectively at 16th day as compared with the control group. 3. The activity of serum ${\gamma}$-GTP of the sample B group decreased effectively at the 16th day as compared with the control group. 4. The activity of serum ALP of the sample A group increased respectively at the 8th and 16th day and sample B group decreased effectively at 16th day as compared with the control group. 5. The activity of serum LDH of the sample A, B groups decreased effectively at 16th day as compared with the control group. 6. The activity of serum total bilirubin of the sample A, B groups decreased effectively at 16th day as compared with the control group. 7. The activity of GOT, GPT, ${\gamma}$-GTP, ALP, LDH and total bilirubin in serum of the sample C group were analogous with thats of normal group.

소아폐렴(小兒肺炎)의 한의학적(韓醫學的) 연구(硏究)에 대한 고찰(考察) -중의학(中醫學) 문헌(文獻)을 중심(中心)으로-

김장현,권혁란,Kim, Jang-Hyun,Kwon, Hyuk-Ran 대한한방소아과학회 2003 대한한방소아과학회지 Vol.17 No.1

Pneumonia is an acute or recurrent infection of the parenchyma of the lung causing cough, fever, and respiratory distress. Pneumonia was named 'Feiyanchuansou(肺炎喘嗽)' in chinese medicine. This study was progressed for oriental medical treatment for pediatric pneumonia in china. The purpose of this study is current oriental medical approach to pediatric pneumonia In this study, the authors tried to figure out the cause of the pediatric pneumonia and its treatment and came to the conclusion as follows: 1. The study for pediatric pneumonia consists of basic, clinical and experimental study. 2. Basic study consists of etiology and pathogenesis(病因病耭), the rule of treatment(治療原則) and method of treatment(治法). 3. Clinical study consists of symptoms-based treatment(辨證論治), adequate prescription treatment(專病專方), acupuncture(鍼灸治療), and western diagnosis based treatment. 4. The majority of experimental study was pharmacology that consists of antiviral and antibacterial effect, removing heat(淸熱), releasing pulmonary qi(宣肺), dissipating phlegm(化痰).

지력증진(智力增進)에 관(關)한 방법론적(方法論的) 연구(硏究)

김장현,Kim Jang-Hyun 대한한방소아과학회 1999 대한한방소아과학회지 Vol.13 No.2

The intelligence is the capacity to recognize the things and implies the meaning of abstract thought, learning and adaptability to the circumstance. Recently, as the promotion of learning ablility and memory attracts many people's attention, many studies of this have been accomplished but the pharmacological methods could not promote the intelligence and memory. In oriental medical theory, the human body is composed of four elements - essence, energy, sprit, blood and among these elements, sprit is considered as the concept of vital energy and mind. Especially, from the Jang-Fu physiological point of view, the memory is closly related with the heart and kidney In oriental medicine, some experiments on animal and literature studies on the subject of memory promotion have done. But because of difference in memory mechanism between man and animal, it is not in reason to apply the result of experiment on animal to human. Therefore I have methodological study of memory promotion to set up the concept of oriental medicine and experimental theory about this and can obtain such conclusion. 1. The oriental medical therapy for memory promotion is following. nourishing the heart and blood, regulating the function of spleen, relieving the mental stress, reinforcing the heart and kidney, invigorating and enriching the blood. 2. The insufficient intelligence in a child is considered to not be full and in an old man, it is considered to decline by degrees. 3. It is needed to molecular biological study of neurotransmitter after the using of oriental medical therapy. 4. It is possible to study using the genetic mutation or observing the collateral of brain nerve cell.

잠용유가 Streptozotocin으로 유발된 흰쥐의 실험적 당뇨에 미치는 영향

김장현,Kim Jang-Hyun 대한한방소아과학회 1996 대한한방소아과학회지 Vol.10 No.1

In order to study the effects of Jamyong-oil(蠶?油) on the diabetic rats induced by streptozotocin, during 15days rats were administered Jamyong-oil after streptozotocin injection(50mg/kg). On 2nd, 9th and 15th day, I investigated the levels of serum glucose, serum total cholesterol, serum triglyceride, serum amylase, and body weight. The last day, I killed rats and investigated hepatic lipid peroxide, tissue amylase. The results were obtained as follows: 1. Serum glucose levels of the sample group decreased effectively (p < 0.05) at the 15th day as compared with the control group. 2. Serum total cholesterol levels of the sample group decreased effectively (p < 0.05) at the 9th and 15th day as compared with the control group. 3. Serum triglyceride levels of the sample group decreased effectively (p < 0.05) at the 15th day as compared with the control group. 4. Activities of the serum amylase of the sample group increased respectively at the 9th (p < 0.05) and 15th (p < 0.01) day as compared with the control group. 5. Body weights of the sample group increased effectively (p < 0.05) at the 15th day as compared with the control group. 6. Hepatic lipid peroxide levels of the sample group decreased significantly (p < 0.01) as compared with the control group. 7. Tissue amylase levels of the sample group increased but not effective as compared with the control group.