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K - 통로개방제가 배양심근세포와 생쥐 체내의 Thallium - 201 역동학에 미치는 영향
이규보(Kyu Bo Lee),이재태(Jae Tae Lee),안병철(Byeong Cheol Ahn),김은지(Eun Ji Kim),손상균(Kang Kyun Sohn),하정희(Jeoung Hee Ha),김천기(Chun K . Kim) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.4
N/A Background: Potassium channel opener (K-opener) opens ATP-sensitive K+-channel located at membrane and induces potassium efflux from cytosol, resulting in intracellular hyperpolarization. Newly synthesized K-opener is currently examined for pharmacologic potency by means of rubidium release test from smooth muscle strip pre-incubated with Rb-86. Since in-vive behavior of thallium is similar to that of rubidium, we hypothesized that K-opener can alter T1-201 kinetics in vivo. Purpose: This study was prepared to investigate the effects of pinacidil (one of potent K-openers) on the T1-201 uptake and clearance in cultured myocyte, and in-vivo biodi- stribution in mice. Methods: Spontaneous contracting myocytes were prepared to imitate in-vivo condition from 20 hearts of 3-5 days old Sprague-Dawley rat and cultured for 3-5 days before use (5×105 cells/ml). Pinacidil was dissolved in 10% DMSO solution at a final concentration of 100nM or 10uM and was co-incubated with T1-201 in HBSS buffer for 20-min to evaluate its effect on cellular T1-uptake, or challenged to cell preparation pre-incubated with T1-201 for washout study. Two, 40 or 100μg of pinacidil was injected intravenously into ICR mice at 10 min after 5μCi T1-201 injection, and organ uptake and whole body retention rate were measured at different time points. Results: Co-incubation of pinacidil with T1-201 resulted in a decrease in T1-201 uptake into cultured myocyte by 1.6 to 2.5 times, depending on pinacidil concentration and activity of T1-201 used. Pinacidil enhanced T1-201 washout by 1.6-3.1 times from myocyte preparations pre-incubated with T1-201. Pinacidil treatment appears to be resulted in mild decreases in blood and liver activity in normal mice, in contrast, renal and cardiac uptake were mildly decreased in a dose dependent manner. Whole body retention ratios of T1-201 were lower at 24 hour after injection with 100μg of pinacidil than control. Conclusion: These results suggest that treatment with K-opener may affect the interpretation of T1-201myocardial images, due to decreasing thallium accumulation and enhancing washout from myocardium.
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이경빈(Lee Kyung Bin),김우제(Kim Woo Je),김은지(K Eun Ji) 한국IT서비스학회 2017 한국IT서비스학회 학술대회 논문집 Vol.2017 No.1
본 논문은 중소기업인 A기업에서 ERP 시스템 구축 정보전략계획 수립을 제안하고 있다. 현재 대부분의 중소기업들이 ERP를 구축하기를 힘들어하고 있는 설정이다. 중소 리서치 회사를 대상으로 기존의 시스템을 개선하여 ERP & 프로젝트 관리 시스템에 대한 정보전략계획을 수립하고, 도입효과를 예측해 본다. 예상 비용과 편익을 분석하여 통합 ERP & EPM 시스템의 도입을 제안한다.
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