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김윤숙(Kim Youn Suk),이병숙(Lee Byoung Sook) 계명대학교 간호과학연구소 2004 계명간호과학 Vol.8 No.1
Purpose : The purpose of this study was to develop an evaluation tool for quality of care in arthritis patient. Method : The approach method of develop tool and tested reliability and validity of tool. 15 nurses participated for tool development, who worked university hospital in Daegu and Kyungbok area, and 20 patient was participated who have operated with arthritis. The data collection was done from 26, september, 2003 to 30, december, 2003. The data were analyzed by Fehring , t-test, Repeated measures ANOVA in SPSS. Result : 1) There were developed 8 standards, 35 criteria and 106 indicators was selected an evaluation tool for quality of care on subject. It was include 4 standard, 22 criteria In process evaluation and 4 standard, 13 criteria in outcome evaluation. 2) Fehring mark that prove signification of standard, criteria, indicators with evaluation of quality care on subject was show 0.85 in mean, 0.81 in criteria, 0.85 in indicators. 3) In the result of analysis interrater reliability used t-test, it was significant on outcome process(p=0.008) and was no significant on total evaluation(p=0.155) and process evaluation(p=0.296) about 28 criteria to nursing recording investigation in developed 35 tool. Conclusion : On the basis of results, this tool is suggesting standard of nursing and improving quality of nursing in arthritis patient.
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한정아(Jeong A Han),추지은(Ji Eun Choo),손지원(Jee Won Shon),김윤숙(Youn Sook Kim),서수연(Su Yeon Suh),안원근(Won Gun An) 한국생명과학회 2019 생명과학회지 Vol.29 No.2
시스템 약리학적 분석을 통해 대회향(Anisi Stellati Fructus)의 활성성분 스크리닝, 표적유전자 확보 및 관련 질병과의 네트워크를 구축한 후 대회향의 항균작용을 중점적으로 분석하였다. Traditional Chinese Medicine Systems Pharmacology (TCMSP) Database 와 Analysis Platform을 통해 대회향의 잠재적 활성성분 49개를 확보하였으며, 그 중 설정한 조건에 부합하는 9개 활성성분을 스크리닝 하였다. TCMSP Database는 활성성분의 약물 동태학적 특성 및 약물-표적-질병 간의 관련성을 네트워크 수준에서 파악할 수 있는 획기적인 in silico적 접근을 가능하게 해준다. 활성성분과 반응하는 201개의 유전자 정보를 UniProt database를 통해 확인하고, 취합한 유전자들이 관여하는 348개의 생물학적 과정을 David 6.8 Gene Functional Classification Tool에서 확보하였다. Chemokine ligand 2, Interleukin-10, Interleukin-6, Tumor Necrosis Factor를 포함한 총 47개의 유전자가 항균작용에 관여하였고 이들을 표적으로 하는 luteolin, kaempferol, quercetin 등이 대표적 항균 관련 활성성분이었다. 이와 같이 확보된 데이터는 연구 재료 선정에 정확성과 시간, 노력, 비용 절감의 효과를 제공함과 더불어 추후 실험적 증명으로 이어져 감염병의 예방과 치료 전략에 과학적인 근거를 제시할 수 있을 것이다. The purpose of this study was to acquire the active compounds of Anisi stellati fructus (ASF) and to analyze the genes and diseases it targets, focusing on its antibacterial effects using a system pharmacological analysis approach. Active compounds of ASF were obtained through the Traditional Chinese Medicine Systems Pharmacology (TCMSP) Database and Analysis Platform. This contains the pharmacokinetic properties of active compounds and related drug–target–disease networks, which is a breakthrough in silico approach possible at the network level. Gene information of targets was gathered from the UnitProt Database, and gene ontology analysis was performed using the David 6.8 Gene Functional Classification Tool. A total of 201 target genes were collected, which corresponded to the nine screened active compounds, and 47 genes were found to act on biological processes related to antimicrobial activity. The representative active compounds involved in antibacterial action were luteolin, kaempferol, and quercetin. Among their targets, Chemokine ligand2, Interleukin-10, Interleukin-6, and Tumor Necrosis Factor were associated with more than three antimicrobial biological processes. This study has provided accurate evidence while saving time and effort to select future laboratory research materials. The data obtained has provided important data for infection prevention and treatment strategies.
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서형주,손종연,김윤숙 한국식품영양학회 1995 韓國食品營養學會誌 Vol.8 No.3
Cheese milk를 기질로 하여 pronase등 protease와 palanatase ML등 lipase를 이용하여 EMC를 제조하였다. Cheese milk 가수분해에 관여하는 각 protease의 반응 조건을 살펴본 결과, pronase-30℃, pH 7.0, pancreatin-40℃, pH 8.0, paciflc protease-30℃, pH 7.0과 Asp. sp. 기원 protease-50℃, pH 8.0에서 최대의 활성을 보였으며, lipase의 반응 조건은 pancreatic lipase-50℃, pH 8.0, palatase ML-50℃, pH 7.0과 Candida cylindracea 기원 lipase-40℃, pH 6.0 이었다. 최적 반응조건에서 가수분해를 행한 결과 반응 시간이 증가할수록 유리아미노산의 양과 유리지방산의 양이 증가하는 경향을 보였다. Pacific protease와 pronase에 의해 가수분해시 0.67㎎/㎖과 0.74 ㎎/㎖의 유리 아미노산을 생성하였으며, 유리 아미노산중 glutamic acid와 leucine이 가장 많은 함량을 보였다. Candida cylindracea 기원 lipase를 이용하여 가수분해시 가장 많은 유리 지방산생성량(24.63 ㎎/㎖)을 보였다. 각 EMC의 지방산조성을 살펴본 결과 butyric acid, palmitic acid, stearic acid와 oleic acid의 함량이 보였다. Pancreatin에 의해 가수분해 후 각 lipase를 사용하여 제조한 EMC의 관능검사 결과, pancreatic lipase를 이용한 EMC가 가장 쓴맛이 강하였고, palatase에 의한 EMC는 가장 바람직한 cheese 향기를 가지고 있다 For the production of EMC, various proteases and lipases were used to hydrolyse cheese milk. The optimal conditions of various proteases were as follows ; pronase-30℃, pH 7.0, pancreatin-40℃, pH 8.0, pacific protease -30℃, pH 7.0 and protease from Asp. sp. -50℃, pH 8.0. The optimal conditions of various lipases were as follows : pancreatic lipase-50℃, pH 8.0, palatase ML-50℃, pH 7.0 and lipase form Candida cylindracea-40℃, pH 6.0. After hydrolysation under optimal conditions, the amounts of free amino acid and free fatty acid were increased with reaction time. Hydrolysates of pacific protease and pronase were showed high amount of free amino acid(0.67㎎/㎖ and 0.74㎎/㎖). Especially EMC had high amount of glutamic acid and leucine. Lipase from Candida cylindracea produced high amount of free fatty acid(24.63㎎/㎖). Butyric acid, palmitic acid, stearic acid and oleic acid among free fatty acids were showed high amounts. Sensory evaluation of various EMC were tasted with 8 panelist. EMC produced with pancreatic lipase was most bitterness and EMC produced with palatase ML was best acceptable cheese flavor.
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