망막모세포종의 효소조직화학적 연구

권의용 ( Eui Yong Kweon ),조남천 ( Nam Chun Cho ) 대한안과학회 2003 대한안과학회지 Vol.44 No.2

맥락막 모반의 스펙트럼영역 빛간섭단층촬영 소견: 초음파 소견과의 비교 연구

권의용,Eui Yong Kweon,MD 대한안과학회 2014 대한안과학회지 Vol.55 No.3

Purpose: To evaluate the characteristics of choroidal nevus using the enhanced depth imaging spectral domain optical coherence tomography (EDI SD-OCT), with a comparison to the B scan ultrasound (BUS) findings. Methods: Medical records of 124 eyes of 124 choroidal nevus patients were reviewed retrospectively. All patients underwent fundus photography (FP), EDI SD-OCT, and BUS. Results: Of 124 eyes with choroidal nevus examined by EDI SD-OCT, 43 eyes (35%) displayed good images to study. The most common EDI-OCT imaging features included choroidal shadowing, choriocapillary thinning, retinal pigment epithelial changes, and overlying subretinal fluid. The mean nevus thickness was 817 μm (120-1850 μm) by EDI-OCT compared 1295 μm (780-2400 μm) by BUS. The mean difference in the tumor thickness between two techniques was 475 μm (27-1319 μm) (p < 0.05). Conclusions: These results have suggested that imaging of choroidal nevus with EDI-OCT shows superior measurement of its characteristics compared with ultrasonography. The clinical utility of this modality is emerging. EDI-OCT is useful in distinguishing suspicious nevi from other chorioretinal lesions, detecting tumor re-growth along the treatment margin, and demonstrating retinal or choroid tumor location. J Korean Ophthalmol Soc 2014;55(3):387-390

중심장액맥락망막병증 환자에서 유리체강내 베바시주맙 주입술의 치료 효과에 영향을 주는 요인

권의용,Eui Yong Kweon 대한안과학회 2014 대한안과학회지 Vol.55 No.3

Purpose: To evaluate the factors influencing the effect of the intravitreal bevacizumab injection in patients with central serous chorioretinopathy. Methods: We performed a retrospective review of the medical records of 54 patients (56 eyes) who had been symptomatic for more than 3 months with central serous chorioretinopathy (CSC), who had undergone intravitreal bevacizumab injection and been on regular follow-up for at least 6 months. Results: Responders were 34 eyes (60.7%) and non-responders were 22 eyes (39.3%). The leaking points of the non-responder group were multiple and located more centrally than that of the responder group on fluorescein angiography (FA) (p = 0.01, p = 0.044). In addition, non-responder group showed cystoid macular edema on optical coherence tomography (OCT) as compared with responder group (p = 0.042). Conclusions: CSC with multiple, centrally located leaks on FA or cystoid macular edema on OCT was ineffective or recurrent with intravitreal bevacizumab injection. J Korean Ophthalmol Soc 2014;55(3):391-395

망막정맥폐쇄 및 당뇨병에 의한 황반부종 환자에서 유리체강내 베바시주맙 주입술의 단기효과

김종연,권의용,이동욱,조남천.Jong Youn Kim. M.D.. Eui Yong Kweon. M.D.. Dong Wook Lee. M.D.. Nam Chun Cho. M.D. 대한안과학회 2008 대한안과학회지 Vol.49 No.8

Purpose: To evaluate the short-term effect and safety of intravitreally injected bevacizumab in patients with macular edema (ME) caused by retinal vein occlusion (RVO) and diabetic macular edema (DME). Methods: We retrospectively evaluated 59 eyes of 51 patients, 29 with ME caused by RVO and 30 with DME, who received intravitreal injection of bevacizumab. Fifty-one consecutive patients (59 eyes) with ME associated with RVO and DME were treated with intravitreal injections of 1.25-2.5 mg (0.05-0.1 ml) of bevacizumab. Ophthalmic evaluation was performed at baseline and at 1, 3, 6 months after each injection. Clinical evidence of toxicity and complications, changes of visual acuity with an ETDRS chart (LogMAR), and central macular thickness (CMT) using optical coherence tomography (OCT), were evaluated. Results: The follow-up period was 7.3 months (7.3±0.31) and the mean number of injections was 1.2. The baseline mean LogMAR was 1.06±0.53 and mean CMT was 479.6±160.4 μm. At 1, 3 and 6 months, the mean LogMAR was 0.90±0.52, 0.80±0.39 and 0.78±0.39, respectively, and the mean CMT was 316.9±86.7 μm, 281.1±67.4 μm and 278.4±64.6 μm, respectively. No adverse incidents were observed, including cataract, retinal detachment, vitreous hemorrhage, and endophthalmitis, although transient increased intraocular pressure was observed. Conclusions: Intravitreal bevacizumab injections are safe and effective in ME caused by RVO and DME. J Korean Ophthalmol Soc 49(8):1275-1282, 2008

안내 이물 제거의 접근방식에 대한 비교

황정호,권의용,조남천,Jeong Ho Hwang,Eui Yong Kweon,Nam Chun Cho 대한안과학회 2010 대한안과학회지 Vol.51 No.2

Purpose: To review the management of posterior segment metallic intraocular foreign bodies (IOFB) and to compare the use of an external approach using a large electromagnet and an internal approach using vitrectomy and its tools for their removal. Methods: A retrospective review was performed on 49 eyes of 49 patients who underwent surgical removal of metallic IOFBs with either an internal or an external approach at a single institution between January 2003 and December 2006. We divided 49 eyes into two groups based on the type of approach: 26 external (n=26) and 23 internal (n=23). Visual acuity and the presence of any complications occurring with the two approaches were the main outcome measures studied. Results: Thirty of 49 eyes (61%) showed improvements in visual acuity. When we compared patients treated with an external versus an internal approach, we found no statistically significant difference in regard to visual outcome. Preoperative vitreous hemorrhage and endophthalmitis were more common in the internal approach group. A trend toward a higher rate of reoperation was more common in the external approach group, but they were not statistically significant. Postoperative complications found to be significantly different between the two groups were the rate of postoperative endophthalmitis and retinal detachment, which were more common in the external approach group. Conclusions: Surgical removal of metallic IOFBs results in significant visual improvement regardless of the approach method. The internal approach by vitrectomy is recommended as the first choice in preoperative conditions such as severe cataracts, vitreous hemorrhage and endophthalmitis, as well as in groups at high risk for postoperative endophalmitis and retinal detachment. J Korean Ophthalmol Soc 2010;51(2):270-275

백내장 수술 후 발생한 안내염 환자에 관한 8년간의 고찰

김우진,권의용,이동욱,조남천,Woo Jin Kim,Eui Yong Kweon,Dong Wook Lee,Nam Chun Cho 대한안과학회 2008 대한안과학회지 Vol.49 No.11

Purpose: To estimate the annual incidence rate, evaluate any changes, analyze the microbiologic spectrum of infecting organisms, antibiotic susceptibility, and factors associated with visual outcomes of postoperative endophthalmitis following cataract surgery over an 8-year period. Methods: A retrospective investigation of direction, sex, age, culture results, interval duration, and initial visual acuity of 29 patients with endophthalmitis following cataract surgery was conducted from January 2000 to December 2007. The study was divided into two 4-year periods, with patients categorized into either Group 1 or 2. Results: The incidence rate was 0.359%, the major infective organism was Staphylococcus epidermidis, and no significant change was observed during the 8-year period. Vancomycin retained efficacy in all cases, but increased resistance occurred with ciprofloxacin during the 8 years. Increased visual acuity after treatment was greater in Group 2 and the interval from onset of ocular symptoms to ophthalmic consultation was shorter in Group 2, although a statistical significance was not demonstrated. Conclusions: Vancomycin remains effective for patients with endophthalmitis following cataract surgery. Patients who initially had good visual acuity showed greater improvement. However, sex, age, or whether or not the patients had a vitrectomy operation, were not statistically significant factors in the improvement of visual acuity. J Korean Ophthalmol Soc 2008;49(11):1771-1778

생쥐를 이용한 스테로이드 유발 고안압 모델

김유라,강완석,권의용,조남천,이동욱,You Ra Kim,Wan Seok Kang,Eui Yong Kweon,Nam Chun Cho,Dong Wook Lee 대한안과학회 2014 대한안과학회지 Vol.55 No.8

Purpose: To determine whether rat eyes develop increases in intraocular pressure (IOP) in response to a topically applied corticosteroid and to investigate the relationship between ocular hypertension and apoptosis of retinal ganglion cells. Methods: IOP was monitored by rebound tonometry in a group of 10 rats that received topically administered dexamethasone in both eyes (experimental) and in another group of 5 rats that received artificial tears (control) three times daily for 4 weeks after the establishment of baseline IOP values. Only eyes that increased by more than 50% compared with the basal IOP were administered once per day for 5 weeks. After 8 weeks, selective immunofluorescence stain for retinal ganglion cells and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) stain were conducted. Results: Among 20 experimental eyes, 11 eyes (55%) showed a greater than 50% increase in IOP compared with basal IOP. After 8 weeks, the mean IOPs for the experimental and control groups were 11.8 ± 1.4 mm Hg and 18.5 ± 1.0 mm Hg, respectively (<em>p</em> < 0.01). The counts of central retinal ganglion cells (RGCs) were 2718 ± 240 and 2612 ± 443, respectively (<em>p</em> = 0.294). The results of the TUNEL stain also showed no differences. Conclusions: Rat eyes exhibit a steroid-induced ocular hypertensive response with no local complications. However, maintaining ocular hypertension increased by 50% for two months was not enough to detect changes in RGCs. J Korean Ophthalmol Soc 2014;55(8):1202-1207

감염성 심내막염에 동반된 백색의 중심을 갖는 망막 출혈

정혜욱,문수정,권의용,이동욱,조남천.Hye Wook Jeong. M.D.. Su Joung Mun. M.D.. Eui Yong Kweon. M.D.. Dong Wook Lee. M.D. Nam Chun Cho. M.D. 대한안과학회 2007 대한안과학회지 Vol.48 No.11

Purpose: To report a case of white-centered retinal hemorrhage in infective endocarditis. Case summary: A 45-year-old patient complained of acute visual loss. The patient had a history of epidural anesthesia for the relief of back pain. On the day of admission the patient showed no light perception and had a white-centered retinal hemorrhage and cotton wool spot in the left eye upon fundus examination. Other ocular manifestations were not specific and there were no specific findings on a brain MRI and visual evoked potential. The patient was diagnosed with pyogenic spondylitis and was treated by abscess drainage and systemic antibiotics therapy. The patient’s near vision improved up to 0.4/0.5. He was diagnosed with infective endocarditis based on the echocardiogram with epidural and subarachnoid hemorrhage. Conclusions: Roth spot can occur in many diseases such as diabetes, leukemia, anemia, and trauma, but most commonly in sepsis due to infective endocarditis. Therefore, medical evaluation and an echocardiogram for patients with white-centered retinal hemorrhage should be considered.

유색가토에서 아르곤 레이저 광응고술 후 뮐러세포의 형태학적 변화

김성훈 ( Seong Hun Kim ),권의용 ( Eui Yong Kweon ),조남천 ( Nam Chun Cho ) 대한안과학회 2002 대한안과학회지 Vol.43 No.2

당뇨병성 망막증 환자에서의 뮐러세포의 형태학적 변화

조남천 ( Nam Chun Cho ),권의용 ( Eui Yong Kweon ),송창호 ( Chang Ho Song ) 대한안과학회 2002 대한안과학회지 Vol.43 No.4