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- 저자 : 권원준(Won Jun Kwon) (검색결과 3 건)
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권원준(Won Jun Kwon),황완균(Wan Kyunn Whang),김일혁(Il Hyuk Kim) 대한약학회 1996 약학회지 Vol.40 No.3
The constituents of Sanguisorba hakusanensis leaves (Rosaceae), of which the roots have been used as an astringent, hemostatics and antiphlogistics, were studied phytochemically. From water fraction of the MeOH extract, gallic acid 3-O-beta-D-(6''-O-galloyl)-glucopyranoside(I), quercetin-3-O-beta-D-galactopyranoside(II), quercetin-3-O-alpha-L-arabinopyranoside(III) and 2alpha, 3beta, 19alpha, 23-tetrahydroxyurs-12-en-28-oic acid 28-O-beta-D-glucopyranoside(IV) were isolated by column chromatographic separation using Amberlite XAD-2, ODS-gel and Sephadex LH-20. The structure of these compounds were elucidated by spectroscopic parameters of 1H-NMR, 13C-NMR, 1H-1H COSY, 13C-1H COSY, EI-Mass, FAB-Mass, IR, UV and by comparison with authentic samples.
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이송득(Song Deuk Lee),이상훈(Sang Hun Lee),최수완(Su Wan Choi),권원준(Won Jun Kwon),김일혁(Il Hyuk Kim) 한국생약학회 1995 생약학회지 Vol.26 No.2
Crinum asiaticum var. japonicum is a wild plant growing only in Jeju-island, Korea, and in Japan. The whole part of this plant has been known to have the pharmacological actions such as analgesic, anti-inflammatory, platelet-aggregation inhibitory, antitussive, and expectorant. With these assumed actions, the leaves (Crinum folium) of this plant has been used in the folk remedies for arthritis and arthralgia. There is, however, no scientific evidences for the pharmacological actions of Crinum asiaticum var. japonicum. In the present study, the analgesic, anti-inflammatory, and platelet-aggregation inhibitory actions of Crinium folium were evaluated using writhing test, tail-flick test, carrageenin antiedema test, in vitro thromboxane B₂ quanti tation assay and in vitro platelet aggregation test. In order to obtain the partially purified fraction whose pharmacological action is excellent, the methanol extract of Crinium folium was fractionated consecutively into four biological fractions such as ether, ethyl acetate, butanol, and water fractions and their pharmacological actions of the fractions were investigated. Putting our results together, Crinum folium, especially ethyl acetate fraction was proven to have significant analgesic, anti-inflammatory and platelet-aggregation inhibitory actions by inhibition of prostanoids biosynthesis as one of its mechanism of action.
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권원준,김일혁 중앙대학교 약학연구소 1992 약학 논총 Vol.6 No.-
These studies were attempted to investigate the preventive effects of KYUNG OK KO and Gluta thione on the liver damage induced by carbon tetrachloride in rats. s-GOT, s-GPT activites and liver TBA values were evaluated. Histological observation were also carred out. The results were summarized as follows: 1. s-GOT, s-SPT activites of all the pre-treatment groups were significantly decreased, as com-pared with those of the control intoxicated by CC1_4. The concurrent adminstration of KYUNG OK KO and Glutathione(100+100mg/kg, 200+100mg/kg, 400+100mg/kg) were more effective than the individual administration. 2. On the determination of lipid peroxidation in liver, the induvidual administration of KYUNG OK KO and Glutathione(100+100mg/kg, 200+100mg/kg, 400+100mg/kg) significantly reduced the liver TBA values. 3. Although hepatic cellular necrosis and fatty acid deposit were remarkably increased by CC1_4 in-toxication, the individual administration of KYUNG OK KO and the concurrent administration of KYUNG OK KO and Glutathione (100+100mg/kg, 200+100mg/kg, 400+100mg/kg) reduced the pathological changes of parenchyma cell necrosis and fatty changes around centrilobular area of the control. In view of the above findings it can be considered that administration of KYUNG OK KO and Glu-tathione showed improvements against liver damage induced by carbon tetrachloride in rats.
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