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- 저자 : 곽동협(Dong Hyeop Kwak) (검색결과 3 건)
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송홍석(Hong Suck Song),조진환(Jin Whan Cho),곽동협(Dong Hyeop Kwak),강영우(Young Woo Kang) 대한내과학회 1987 대한내과학회지 Vol.32 No.4
N/A The authors reviewed the Kortean Literature extensively in search of hereditary spherocytosis, and find 46 patients and 22 analyzable family members. Then, a clinical study was carried out retrospectively on 73 patients with hereditary spherocytosis including 5 patients from the Dongsan hospital, Keimyung University, The result of the this study were as follows: Male to female ratio was 1:1.2 with slight female predominance and the age distribution was between 3 month and 53 years with mean age of 16.9 years. Family history was present in 54.3%. The age of onset in 53 symptomatic patients was below 1 year in 12 cases, 1-10 years in 29 cases, over 10 years in 12 cases, and the duration of symptams were below l year in 13 cases, 1-10 years in 25 cases and over 10 years in 15 cases. Pallor and jaundice were the most frequent complaint (29 cases: 41.4%). Abdominal mass was observed in 13 cases (18.6%), general weakness in 12 cases (17.1%), dizziness in 11 cases (15.7%), abdominal pain in 8 cases (11.4%), anorexia in 4 cases (5.7%) in order of frequency, and the subjective symptom was absent in 14 cases (20%). Physical findings revealed pallor in 78.5%, jaundice in 73.4%, splenomegaly in 89.4%, hepatomegaly in 68.9%, cardiac murmur in 50%, growth retardation in 11.5%, and the spleen was enlarged below the left costal margin with mean size of 6.2±4.1 cm and the liver was enlarged below the right costal margin with mean size of 3.5±1.9 cm, Laboratory findings revealed anemin (Hb<12 gm/dl) in 91,8% with mean of 8.4±2.5 (range: 3.9±14.5) gm/dl, reticulocytosis in 93,3% with mean of 9,6+11.9 (range: 0. 1 76.0)%, and hyperbilirubinemia in 93 with mean of 4.0±3.9 (range: 0.6-27.4) mg/dl. Mean corpuscular volume was increased in 20%, normal in 70%, and decreased in 14% with mean of 92.7±13.8 (range: 68-144) fl, and mean corpuscular hemoglobin concentration was in- creased in 16%, normal in 58%, and decreased in 26% with mean of 32.8±2.9 (range: 25.7-40.0) pg. In osmotic fragility test, initial concentration of hemolysis above 0.51% was 54 cases (94.7%) with mean of 0.66±0.11 (range: 0.38-0.90)%. Splenectomy was performed in 38 cases and the aver- age weight of the spleen was 633±389 (range: 150-1.500) gm, and the accessory spleen was found in 10 cases (26.3%). There was no significant difference between male and female, and also present and absent family history groups, but statistically significant correlation was found between spleen size and hemoglobin, spleen size and MCV, liver size and MCV, negatively, and MCHC and initial concentration of osmotic fragility test positively (p<0.01).
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김윤년,송홍석,곽동협 대한내과학회 1986 대한내과학회지 Vol.30 No.2
A clinical review was done retrospectively on 105 patients with histiocytic lymphoma who visited to the Dong San Medical Center between Jan. 1974 and Aug, 1984, The results of the this study were as follows: JVIale to female ratio was 1.56:1 with male predorminance and the age distribution was between 4 and 82 with mean age of 44,7 years. Palpable neck mass was the most frequent complaint(52cases: 49.5%). Abdominal pain, fever were observed in 14 cases (13.3%) respectively and abdominal mass in 11 cases(10.5%), weight loss in 9 cases(8.6%), throat pain in 9 cases(8.6%) and abdominal swelling in 8 cases(7.6%). Physical findings revealed lymph node enlargement in 74cases (70.5%) with cervical, inguinal, axillary, mesenteric and supraclavicular in order of frequency. Hepatomegaly was observed in 17.1% splenomegaly in 2.5% and abdominal mass in 20cases(19.0%). Extranodal involvement was observed in 71 cases(67.6%) and organs of involvement were as follows: GIT in 18 cases(17.1%), waldeyer`s ring in 17 cases(16.2%), skin in 16 cases(15.2%) liver in 7 cases(6.7%), bone in 6 cases(5.7%), bone marrow in 5 cases(4.8%), retroperitoneum in 5 cases(4.8%), anterior nasal cavity in 4 cases(3.8%), lung and pleura in 2 cases(l.9%) respectively. Laboratory findings revealed anemia in 47.1%, leukocytosis in 27.5%, leukopenia in 14.7% lymphopenia in 43.4%, hypoalbuminemia in 31.5%, azotemia in 10.4%, increased alkaline phosphatase in 13.9% and hypercalcemia in 8.2%. By Ann Arbor staging, stage I was in 23cases (21.9%), stage g in 34cases(32.4%), stage III in 16cases(15.2%), stage g in 32 cases(30.5) and stage B in 20 cases(27.6%). Treatment was performed as follows: Radiotherapy in 20 cases, combination chemotherapy in 18 cases and combined modality therapy in 8 cases. After treatment, 5 year survival rate was 72.2% in adequately treated patients. 2 year survival rate was 83.4% in complete remission group and 58.6% in partial remission group and there was no long-term survival in patients with partial remission.
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서승연,한승범,오영철,곽동협,송홍석,김윤년,김권배 啓明大學校 醫科大學 1986 계명의대학술지 Vol.5 No.1
We experienced fourteen patients with constrictive pericarditis, who were admitted to the Dong San Hospital, Keimyung University and treated by pericardiectiomies during the seven year periods between Jan 1980 and May 1986. The results of our experience were as follows: They were 10 males and 4 females and male to female ratio was 2.5 : 1 and age distribution was between 11 and 66 with mean age 46.4 years. The intervals between initial symtoms for acute pericarditis and the pericarditis were about 123.3 days and intervals between initial treatmetn for acute pericarditis and operation were about 55.4 days. Pleural effusion was noted in 55.7%, enlarged cardiac shadow in 50% and pericardial calcification in 7% on the chest roentgenograms. Regular sinus rhythem was noted in 100%, low voltage in 64%, T wave change in 71% and ST segment changes in 7% on the electrocardigram. The results of pericardial biopsy were tuberculosis in 57%, nonspecific chronic inflammation in 28%, purulent infection in 7% and neoplastic cell infiltration in 14%.
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