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절반용량의 광역학치료를 받은 만성 중심장액맥락망막병증에서 스펙트럼영역 빛간섭단층촬영 소견과 시력과의 상관관계
박시윤,고형준,김용민,Si Yoon Park,Hyung Jun Koh,Yong Min Kim 대한안과학회 2013 대한안과학회지 Vol.54 No.11
Purpose: To evaluate the results of half-dose photodynamic therapy (PDT) and determine the correlation between morphological changes measured by spectral-domain optical coherence tomography (SD-OCT) and visual acuity in patients with chronic central serous chorioretinopathy (CSC). Methods: Twenty-five eyes of 25 patients with chronic CSC who had received half-dose verteporfin PDT were enrolled in the present study. The best-corrected visual acuity (BCVA), outer nuclear layer (ONL) thickness, and the integrity of the photoreceptor inner and outer segment junction (IS/OS) using SD-OCT were evaluated at baseline and at 3 and 6 months after treatment. Results: The neurosensory retinal detachment disappeared in all eyes 6 months after treatment. The BCVA improved significantly from 0.50 ± 0.32 to 0.31 ± 0.29 log MAR at 6 months (p < 0.001). The average ONL thickness at the central fovea was 88.76 ± 19.95 μm at 6 months and the ONL thickness was well correlated with the BCVA (γ = -0.64; p = 0.001). There was no significant correlation between the status of IS/OS and the BCVA. Conclusions: Half-dose PDT is effective in treating chronic CSC resulting in visual improvement and complete resolution of neurosensory retinal detachment. The ONL thickness which was positively correlated with the BCVA could be an indicator for visual prognosis of chronic CSC. J Korean Ophthalmol Soc 2013;54(11):1715-1722
당뇨황반부종의 치료에서 유리체 절제술의 효과와 유리체강 내 트리암시놀론 주입술과의 비교
김용민,김성수,이성철,권오웅,고형준,Yong Min Kim,Sung Soo Kim,Sung Chul Lee,Oh Woong Kwon,Hyung Jun Koh 대한안과학회 2006 대한안과학회지 Vol.47 No.7
Purpose: The purpose of this study is to evaluate the benefit of pars plana vitrectomy (PPV) and removal of the internal limiting membrane (ILM) in diabetic macular edema, and to compare the effects of PPV and removal of ILM with intravitreal triamcinolone acetonide injection. Methods: Fifteen eyes of 14 patients on whom PPV and removal of the ILM (group A) were performed and 14 eyes of 14 patients who received single intravitreal triamcinolone acetonide injection (group B) for diabetic macular edema over six months were included in this study. The main outcome measures were macular thickness, as measured by optical coherence tomography and visual acuity at 1, 3, and 6 months postoperatively. Results: The mean preoperative visual acuity was 0.06±0.05 and macular thickness 516.01±120.29 ?m in group A. At 1 month postoperatively, this group showed no significant improvement of visual acuity. However, there was significant improvement at 3 and 6 months postoperatively. Macular thickness also decreased significantly at 1, 3, and 6 months postoperatively. In group B, the mean preoperative visual acuity was 0.10±0.08 and macular thickness was 548.82±116.44 ?m. At 1 and 3 months postoperatively, significant improvement of visual acuity was noted in this group. However, there was no significant difference at 6 months postoperatively. Macular thickness also decreased significantly at 1, 3, and 6 month postoperatively. Between two groups, visual acuity and macular thickness improved in Group B at 1 month postoperatively but at 6 months, visual acuity improved in Group A and there was no significant difference of macular thickness between the two groups. Conclusions: PPV and removal of the ILM are good therapeutic options for diabetic macular edema to improve visual acuity and macular thickness. These also offer more long term efficacy than intravitreal tiamcinolone acetonide injection.