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이규섭(Kyu-Sop Lee),조정원(Chong-Woon Cho),강문규(Moonkyu Kang),배현수(Hyunsu Bae),김경수(Kyung-Soo Kim),심인섭(Insop Shim) 대한스트레스학회 2008 스트레스硏究 Vol.16 No.2
연꽃의 씨앗인 연자육(Nelumbinis semen)은 전통적으로 불면증. 불안장애나 여성의 갱년기 우울증에 처방되어 오던 약재이다. 만성스트레스 동물 모델을 이용한 선행연구에서 연자육이 항우울 효과가 있다는 것이 이미 밝혀져 있다. 본 연구에서는 항우울제의 효과를 검증하는데 널리 쓰이는 강제수영검사(forced swimming test)를 이용하여 연자육에서 항우울 효과를 나타내는 활성물질을 규명하고자 하였다. 연자육은 5개의 분획[water, ethyl acetate, n-butyl alcohol(n-BuOH), n-hexane, ethanol]으로 나누어 추출하였고, 실험동물에게 각각의 분획을 투여한 뒤에 강제수영 검사를 통하여 그 효과를 검증하였다. 추출된 연자육의 모든 분획에서 부동자세(immobility time)의 감소로 항우울 효과를 확인하였으며, n-BuOH층을 선택하여 water와 methanol의 비율에 따라 5개의 분획으로 세분화하고 강제수영검사를 이용하여 연자육의 항우울 효과를 확인하였다. n-BuOH 추출물에서 가장 뛰어난 효과를 보인 분획은 water와 methanol의 비율이 3:7에서 추출된 물질로 추후 이 물질의 정확한 작용기전의 규명이 이루어져야 할 것이다. Depression is a major mood disorder, characterized by depressed mood, feeling of worthlessness and disturbed appetite. Nelumbinis semen (NS), lotus seed, has been widely used in Korean traditional medicine as a remedy for insomnia, anxiety, and women"s depression following post-menstrual-pause. We recently found NS to have an anti-depressant effect on chronic mild stress-induced depression-like symptom in the rat. The purpose of the present study was to examine the effect of NS extracs on depression-like symptom in the forced swimming test (FST) in the rat, which is widely used as a behavioral screening test for antidepressant activity of new compounds. We prepared five extracts using water, ethyl acetate, n-butyl alcohol, n-hexane and ethanol as solvents. When animals treated with each extract were executed on FST, n-butyl alcohol extract showed the strongest inhibitory effect on the immobility time. We further fractionated n-buthyl alcohol into five feactions with different mixture of water and methanol, and the 3:7 (water:methanol) fraction was the most effective on the immobility time on FST. In further study, unknown compounds in this fraction and neural mechanisms underlying their anti-depressant actions should be examined.
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Jang, Choon-Gon,Kang, Moonkyu,Cho, Jae-Han,Lee, Sun-Bok,Kim, Hyuntaek,Park, Soonkwon,Lee, Jinwoo,Park, Seong-Kyu,Hong, Moochang,Shin, Min Kyu,Shim, In-Sup,Bae, Hyunsu WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-
Depression is associated with a dysfunctional serotonin (5-hydroxytryptamine; 5-HT) system. More recently, several lines of evidence suggest that an important factor in the development of depression may be a deficit in the function and expression of 5-HT_(1A) receptors. The present study assessed if Nelumbinis Semen (N. s.) had an anti-depression effect through reversing a decrease in 5-HT_(1A) receptor binding in rats with depression-like symptoms induced by chronic mild stress. Using a 5-HT_(1A) receptor binding assay, with a specific 5-HT_(1A) receptor agonist, 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino) tetralin), the mechanism of the anti-depression effect of N. s. on rats was investigated, and the effects compared with two well-known antidepressants, Hyperium Perforatum (St. Johns Wort) and fluoxetine (Prozac). Animals were divided into live groups: the normal (N) group without chronic mild stress (CMS), the control (C) group under CMS for 8 weeks, the Nelumbinis Semen (N. s.) treatment group under CMS for 8 weeks, the Hyperium Perforatum (H. p.) treatment group under CMS for 8 weeks and finally, the fluoxetine (F) treatment group under CMS for 8 weeks. Each treatment was administered to rats during the last 4 weeks of the 8-week CMS. A sucrose intake test was performed to test the anti-depression effect of N. s. The N. s. treatment significantly reversed the decreased sucrose intake under CMS (P<0.05 compared to control group under CMS). In the CA2 and CA3 regions of the hippocampus, both N. s. and H. p. reversed the CMS-induced decrease in 5-HT_(1A) receptor binding. In the Ⅰ to II regions of the frontal cortex, N. s. and H. p. also reversed the CMS-induced decrease in 5-HT_(1A) receptor binding, and even showed a significant increase in 5-HT_(1A) receptor binding compared to the F treatment group (N. s. vs. P₁ p<0.05, H. p. vs. P₁ p<0.05). However, in the hypothalamus, all treatments reversed the CMS-induced decrease in 5-HT_(1A) receptor binding. This reversal effect of N. s. on the decrease in 5-HT_(1A) receptor binding in the frontal cortex, hippocampus and hypothalamus of rat brains was very similar to that of H. p, but different from that of F. It is concluded that N. s. presents an anti-depression effect through enhancing 5-HT_(1A) receptor binding.
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