酒精精神病 患者에 對한 臨床的 硏究

高炳鶴 충남대학교 의과대학 지역사회의학연구소 1979 충남의대잡지 Vol.6 No.2

For the studying of various clinical phenomena of alcoholic psychoses, 42 hospital admission charts recorded in the psychiatry unit of Chungnam National University Hospital from March 1975 to July 1978 were analysed statistically and the following results were obtained: 1. The prevalent age of habitual alcoholism and alcoholic psychoses was in the 40th and the mean age was 43.5 years old. 2. Delirium tremens was the most frequent clinical subtype of the alcoholic psychoses (61.9%). 3. The mean duration of drinking alcohol of the alcoholic psychoses was 11-20 years. 4. The most frequent cause of drinking might be a result of emotional frustrations. 5. The most frequent findings of the somatic complications of the alcoholic psychoses were those of liver damage(26.1%). 6. About Delirium tremens: a. Most of the D. T's did not have foods before and after the onset of the clinical symptoms (80.7%). b. Convulsive seizures were developed in 7 cases (26.9%). c. The average duration of alcohol withdrawal before the onset of delirium was 5-7 days.

憂鬱症의 診斷尺度에 關한 硏究 : Zung의 憂鬱尺度表의 適用을 爲하여 for adjustment of Zung's Self-Rating Depression Seale and Depression Status Inventory

高炳鶴 충남대학교 의과대학 지역사회의학연구소 1977 충남의대잡지 Vol.4 No.1

For the purpose of clincal use of the Zung's Self-Rating Depression Scale 103 psychiatric patients were adjusted by the Self-Rating Depression Scale and the Physician's Depression Status Inventory at the same time. Data from this study was presented as follows; The validity of SDS was shown by the high correlation with the DSI in depression (r=0.83, P=<0.001). It's ability to differentiate depressed patients from nondepressed patients was further shown by the fact that; depressed patients was 73, of patient with schizophrenia, anxiety neuroses, and others were 56, 58 and 59 respectively, P=<0.001 in all instances. The mean DSIZ score of depressed patients was 64, of patient with schizophrenia, anxiety neuroses, and others were 45, 45 and 44 respectively, P=<0.001 in all instances. As a result of the above data, we have come to the conclusion that when using DSI and SDS properly it can be a valuable tool in evaluating the depressive patient.

精神分裂症의 生物學的 硏究 : 液體 크로마토그라프와 放財酵素法에 依한 Catecholamines 微量定量 A Rapid Microassay of Catecholamines by High Performance Liquid Chromatography-Radioenzymatic Method

고병학,송옥헌,임규,황병두,백문기 中央醫學社 1983 中央醫學 Vol.45 No.4

A direct rapid radioenzymatic assay in combination with high performance liquid chromatography (HPLC) for measuring simultaneously picogram quantities of nore pinephrine, epinephrine and dopamine has been developed, and the relationship of changes in cerebrospinal fluid (CSF) norepinephrine concentration during haloperidol treatment to changes in psychosis rating of twelve schizophrenic patients has been investigated. The three catecholamines in 20?l of CSF are converted to their 0-methylated ana-logues by catechol-0-methyltransferase in the presence of S-adenosyl-L-1{methyl-3H} methionine. After the addition of tetraphenylborate, these derivatives are extracted. with diethylether at pH 8.2 followed by re-extraction with 0.1N HCI and then isol-ated by HPLC using, ?Bondapak C18column and 0.17 M acetic acid-60% methanol- 0.02 M Na2SO4 as solvent. Manual collection of each fraction is started two seconds after in appeared mark. The HPLC fraction of norepinephrine and epinephrine deri-vatives are oxidized to vanillin followed by extracting the vanillin with toluene, and dopamine derivatives fraction is extracted with toluene/isoamylalcohol and then re-extracted with 0.1N HCl. Internal standard curve shows a good linearity from 5 to 30 picogram per samples, and incorporated radioactivity of norepinephrine, epinephrine and dopamine derivatives are 163±11.4, 125±10.5 and 112±3.9cpm per picogram and calculated sensitivities are 0.4, 0.3 and 1 picogram, respectively. 3H-Normetanephrine, 3H-metanephrine and 3H-methoxytytamine are well separated by HPLC, and each retention times are 3.52, 4.08 and 5.62 minutes and yields are 75.6?0.9, 76.1?0.8 and 70.1?0.4%. Separation of the methylated derivatives by HLPC are performed within 8 minutes, and thus enabled us to complete the differential analysis of 15 samples (30 tubes) in a day. CSF norepinephrine concentration in schizophrenic patients show rostral-caudal gradient and haloperidol induced decreases of norepinephrine and the decreases correlated significantly with psychosis rating, From the above rsults, it is suggested that this method is more excellent than any others in sensitivity, accuracy, reproducibility and specificity of the differential assay, and CSF norepinephrine can be used for evaluation of neuroleptics treatment of schizophrenia by this method.

精神病院 및 精神科醫師에 對한 態度에 關한 硏究

高炳鶴 충남대학교 의과대학 지역사회의학연구소 1977 충남의대잡지 Vol.4 No.2

For the purpose of the control study of popular attitudes to psychiatry unit and psychiatrist this author selected 342 government employees for the study object and analysed the data. Generally they accepted that the psychiatry unit and psychiatrist are responsible to the psychologic problems and their treatment and accepted our developing psychiatric trend in Korea. Theses acceptable attitudes are higher in percentage among higher educated persons. The attitude to psychiatry unit in general hospital is more acceptable than the private psychiatric clinic but in woman college and above fourty age man groups they revealed more acceptable attitude to the private psychiatric clinic and in under thirty age man and woman group revealed remarkedly negative attitude to the private psychiatric clinic. Fears to the psychiatric facilities and psychiatrist are generally higher percentage, especially in woman group, but these fears to psychiatric facilities and psychiatrist are about equal in percentage compared to that of general hospital and nonpsychiatric doctor which suggested that they generally accepted the psychiatry as a modern scientific medical model.

Austria(Wien 大學)의 정신의학

고병학 서울대학교 의과대학 정신과학교실 1980 精神醫學報 Vol.4 No.3

神經安定劑에 對한 態度 및 信賴에 關한 調査硏究

高炳鶴 충남대학교 의과대학 지역사회의학연구소 1978 충남의대잡지 Vol.5 No.2

In light of the current rapid growth in the production and prescription of psychotherapeutic sedatives in Korea, this author surveyed the popular attitudes and beliefs about tranquilizers. The control group(192 men and women who had not experienced tranquilizers) and the neurotic patient group(110 people)were surveyed by the prepared paper and pencil method in the city of Dae Jeon, Korea, (population 550, 000)from March 1, 1977 to March 31, 1977. Data from the study show that; 1. Considerable evidence of attitudes acceptable to the drug efficacy was revealed in 70%, but they have doubts about full recovery from their illness by the drugs. In about 80% of that cases those studied believed that the drug is efficient only for temporal symptom relief. 2. The more severe the degree of difficulty in adjustment to the family and working situations, the more they tended to want to take the tranquilizers. But there are no distinguishing causes to he discriminated between the general attitudes and beliefs about the drugs and the real desire for taking tranquilizers. 3. among the unwanted effects of tranquilizers, habituation and toxic harmful effect on soma were worried about the moat (79%) and this concern was about 2 times higher in the control group than in the patient group. 4. They were willing to think that their illness should he treated by their own will and accordingly they tended to accept their weakness of will which led them to take tranquilizers. These attitudes are found more in the lower educated and patients groups. By this data we would like to suggest that they generally do not want to take any tranquillizers if possible. 5. Finally we comented on the necessity of the therapist's psychological understanding the patients and further study about the symbolic meanings of tranquilizers to the patients in view of the traditional Korean perspective on psychiatric practice and social morality.

一部農村地域의 腸病 및 醫療에 關한 調査

高炳鶴 全南大醫大 1974 전남의대학술지 Vol.11 No.4

中·高校 敎師의 疲勞度에 關한 調査硏究

高炳鶴 全南大醫大 1974 전남의대학술지 Vol.11 No.3

精神分裂症의 忘想과 精神治療에 關한 現象學的 考察

高炳鶴 충남대학교 의과대학 지역사회의학연구소 1983 충남의대잡지 Vol.10 No.2

For the review of phenomenological understanding of schizophrenia, the philosophical and the psychiatric phenomenologies were reviewed in a different chapter and a final analysis conclusion was taken that the essential characteristics of phenomenological understanding of human phenomena(i, e, schizophrenia)is the personality of therapist. Depend upon the therapist's personality, whether it has it's ability to be the transcendental ego for operating of the eidetic and transcendental reductions, or no, the patient's subjective world could be reconstructed or not. But what will be the way of becoming a phenomenologist was not reviewed, because it was thought to be out of scope in this review and leaves some blank for the next opportunity.

한국인의 생활사건에 관한 예비적 연구 I . 생활사건 척도

고병학,송옥헌,신윤오 대한신경정신의학회 1981 신경정신의학 Vol.20 No.1

For rating emotional responses to the everyday life events, 61 life events were tested by 528 normal persons by the method of paper and pencil questionairs. Among 528 respondents, 300 persons’ (men 150, women 150) were selected randomly and the reports were analysed statistically. The results were as follows; 1. Emotional responses of 61 life events were rated and the events were put in rank order according to the mean value of the em otional responses in negative sense. The most negatively responded life events were death of, spouse (M=17. 574) and death of child (M = 1 7 .481), and the least responded events were many trivial life events and desirable ones in positive sense, e.g. engagement of offsprings (M = 2.188) and promotion (M = 1.988) etc. 2. Average number of life events which had occurred during one year (1979) was 3.213 in man, 2.580 in woman, and 3.930 in total. 3. Among the occurred life events, death of a member of the family, reunion of separated spouses, hospital admission due to serious illness, involutional period, trivial legal problems, and moving house in the same city were significant by statistically. 4. By factor analysis, it was found that the factor most highly invested emotionally was related to bereavement (M=15. 528) and the least invested emotionally was related to to moving house(M=5.824).