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Unilateral rostral mandibulectomy for gingival vascular hamartoma in two calves
Takeshi Tsuka,Yoshiharu Okamoto,Naoki Yamamoto,Keiji Hayashi,Takehito Morita,Yuji Sunden,Yusuke Murahata,Kazuo Azuma,Tomohiro Osaki,Norihiko Ito,Tomohiro Imagawa 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.4
A 2-month-old female Holstein calf and a 5-month-old female Japanese black calf presented with gingival vascular hamartoma located in the interdental space between the second and third mandibular incisors in the right and left mandibles, respectively. On radiographic or computed tomographic images, osteolytic changes appeared within the mandibular bones adjacent to the masses. The masses were removed along with affected mandibular bone by using unilateral rostral mandibulectomy. After surgery, both cases exhibited a normal appetite and grew normally, with no cosmetic changes or recurrences. Unilateral rostral mandibulectomy can be applied for invasive gingival vascular hamartomas associated with osteolytic changes.
Plasma free amino acid profiles of canine mammary gland tumors
Kazuo Azuma,Takeshi Tsuka,Tomohiro Imagawa,Saburo Minami,Yoshiharu Okamoto,Tomohiro Osaki 대한수의학회 2012 JOURNAL OF VETERINARY SCIENCE Vol.13 No.4
The purpose of this study was to elucidate the relationship between plasma free amino acid (PFAA) levels and the clinical stages of mammary gland tumors (MGT) in dogs. PFAA levels in canines with malignant mammary tumors were decreased compared to those of healthy animals. The levels of aspartate and ornithine, in the dogs with tumor metastasis were significantly decreased when compared to those of dogs that did not have metastases. Results of this study indicate that PFAA levels could be a risk factor or biomarker for canine MGT metastasis.
Establishment of a canine mammary gland tumor cell line and characterization of its miRNA expression
Tomohiro Osaki,Yuji Sunden,Akihiko Sugiyama,Kazuo Azuma,Yusuke Murahata,Takeshi Tsuka,Norihiko Itoh,Tomohiro Imagawa,Yoshiharu Okamoto 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.3
Canine mammary gland tumors (CMGTs), which are the most common neoplasms in sexually intact female dogs, have been suggested as a model for studying human breast cancer because of several similarities, including relative age of onset, risk factors, incidence, histological and molecular features, biological behavior, metastatic pattern, and responses to therapy. In the present study, we established a new cell line, the SNP cell line, from a CMGT. A tumor formed in each NOD.CB17-Prkdcscid/J mouse at the site of subcutaneous SNP cell injection. SNP cells are characterized by proliferation in a tubulopapillary pattern and are vimentin positive. Moreover, we examined miRNA expression in the cultured cells and found that the expression values of miRNA-143 and miRNA-138a showed the greatest increase and decrease, respectively, of all miRNAs observed, indicating that these miRNAs might play a significant role in the malignancy of SNP cells. Overall, the results of this study indicate that SNP cells might serve as a model for future genetic analysis and clinical treatments of human breast tumors.
Masaki Onoyama,Takeshi Tsuka,Tomohiro Imagawa,Tomohiro Osaki,Saburo Minami,Kazuo Azuma,Kazuhiko Kawashima,Hiroshi Ishi,Takahiro Takayama,Nobuhiko Ogawa,Yoshiharu Okamoto 대한수의학회 2014 JOURNAL OF VETERINARY SCIENCE Vol.15 No.1
Sixteen cases of malignant soft tissue sarcoma (STS; 10canines and six felines) were treated with a novel tripletherapy that combined photodynamic therapy, hyperthermiausing indocyanine green with a broadband light source, andlocal chemotherapy after surgical tumor resection. This tripletherapy was called photodynamic hyperthermal chemotherapy(PHCT). In all cases, the surgical margin was insufficient. Inone feline case, PHCT was performed without surgicalresection. PHCT was performed over an interval of 1 to 2 weeksand was repeated three to 21 times. No severe side effects,including severe skin burns, necrosis, or skin suture rupture,were observed in any of the animals. No disease recurrence wasobserved in seven out of 10 (70.0%) dogs and three out of six(50.0%) cats over the follow-up periods ranging from 238 to1901 days. These results suggest that PHCT decreases the riskof STS recurrence. PHCT should therefore be considered anadjuvant therapy for treating companion animals with STS inveterinary medicine.