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      • Investigation of dynamic response of "bridge girder-telpher-load" crane system due to telpher motion

        Maximov, Jordan T.,Dunchev, Vladimir P. Techno-Press 2018 Coupled systems mechanics Vol.7 No.4

        The moving load causes the occurrence of vibrations in civil engineering structures such as bridges, railway lines, bridge cranes and others. A novel engineering method for separation of the variables in the differential equation of the elastic line of Bernoulli-Euler beam has been developed. The method can be utilized in engineering structures, leading to "a beam under moving load model" with generalized boundary conditions. This method has been implemented for analytical study of the dynamic response of the metal structure of a single girder bridge crane due to the telpher movement along the bridge girder. The modeled system includes: a crane bridge girder; a telpher, moving with a constant horizontal velocity; a load, elastically fixed to the telpher. The forced vibrations with their own frequencies and with a forced frequency, due to the telpher movement, have been analyzed. The loading resulting from the telpher uniform movement along the bridge girder is cyclical, which is a prerequisite for nucleation and propagation of fatigue cracks. The concept of "dynamic coefficient" has been introduced, which is defined as a ratio of the dynamic deflection of the bridge girder due to forced vibrations, to the static one. This ratio has been compared with the known from the literature empirical dynamic coefficient, which is due to the telpher track unevenness. The introduced dynamic coefficient shows larger values and has to be taken into account for engineering calculations of the bridge crane metal structure. In order to verify the degree of approximation, the obtained results have been compared with FEM outcomes. An additional comparison has been made with the exact solution, proposed by Timoshenko, for the case of simply supported beam subjected to a moving force. The comparisons show a good agreement.

      • Slide Session : OS-END-08 ; Diabetes : Diabetes Mellitus in Young People: Clinical and Molecular Genetic Aspects

        ( Alla Ovsyannikova ),( Oksana Rymar ),( Vladimir Maximov ),( Mikhail Voevoda ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        Background: The aim was to investigate the clinical, laboratory and genetic determinants of diabetes mellitus in patients with debut of disease before 25 years of age and family history of diabetes in Siberia. Methods: We examined 70 people with debut of diabetes before 25 years of age with family history of diabetes: 5 patients who we verified MODY 2 (after molecular genetic testing), 33 diagnosed with type 1 diabetes at 32 - 2 type. All patients had a clinical examination, blood sampling for biochemical, hormone and molecular genetic (research glucokinase gene) analyzes. Results: Missense mutations in the glucokinase gene were localized in exons 1,4 and 7. The “classical” symptoms of debut were in 94% of patients with 1 type of diabetes. Asymptomatic debut of “diabetes no type 1” was in 60% of patients. Allergic reactions dominated among the comorbidities in patients with diabetes. Pathologies of the gastrointestinal tract (diabetes mellitus type 1 -27%, 2 type -12 %, MODY 2-20%), thyroid (18 %, 28 % and 40 % respectively), hypertension (18 % with type 1, 28 % - type 2) were in these patients. Peripheral diabetic neuropathy and diabetic retinopathy prevailed among the complications. Statistical differences were found in glucose, glycated hemoglobin, C-peptide, C-reactive protein among laboratory parameters in patients with diabetes mellitus type 1 and type 2. Conclusions: 1. We discovered a new one missense mutation and three previously described mutations in the glucokinase gene. 2. Young patients with type 1 diabetes had “classic” symptoms. Patients with “diabetes not type 1” had not clinical symptoms (60%) and had normal body weight (84 %). 3. Allergic reactions and diseases of the thyroid gland dominated in all types of diabetes mellitus in patients of the young age.

      • Poster Session:PS 0171 ; Diabetes : The Prevalence of Hypertension in Young Patients with Diabetes Mellitus

        ( Alla Ovsyannikova ),( Oksana Rymar ),( Vladimir Maximov ),( Mikhail Voevoda ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        Background: The aim of research was to determine the incidence of arterial hypertension in patients with debut of diabetes mellitus before 25 years of age. Methods: We examined 70 people in Siberia who had debut of diabetes mellitus up to 25 years: 5 patients had been confi rmed MODY 2, 33 patients had type 1 diabetes, 32 patients - type 2. We have done clinical examination, measurement of blood pressure, blood sampling for biochemical and hormone (TSH, C-peptide) analyzes. Arterial hypertension was diagnosed when blood pressure (BP) is above then 139/89 mm Hg for people older 18 years and above 95 percentile of the distribution BP for patients younger than 18 years. Results: The median of age of the patients at moment of examination was 23,0 [16,0:35,5] years for patients with type 1, with type 2- 29,5 [17,7:37,0] years (p1- 2<0,001), with MODY 2 -13,0 [6,5:30,5] years (p2-mody=0,022). The median of duration of diabetes mellitus was 9,0 [3,5:19,5] years at type 1: 2,0 [1,0:5,0] years at type 2: 3,0[1,0:4,0] years at MODY 2 (p1-2 = 0,02, p1- MODY = 0,04). 5 patients (15%) with type 1 diabetes had hypertension 1 and 2 degrees. 6 patients (19%) with type 2 diabetes also have high blood pressure. Patients with MODY 2 had not arterial hypertension. Overweight was present in 2 patients (6%) with type 1 diabetes and in 5 (16%) - with type 2 diabetes. Conclusions: 1. Young patients with diabetes have high incidence of hypertension which requires good monitoring pressure in these patients from the time of diagnosis of diabetes. 2. Overweight in young patients with diabetes is rarer than hypertension. It is indicate the need for controlling the pressure in the persons not only with the overweight but with normal weight too.

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