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- 저자 : ( Sami Habiballa Abdullah ) (검색결과 1 건)
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( Jamal Al Wakeel ),( Ziyad Makoshi ),( Mohammed Al Ghonaim ),( Ali Al Harbi ),( Abdulkareem Al Suwaida ),( Farjah Algahtani ),( Mogbil Al Hedaithy ),( Sultan Almogairin ),( Sami Habiballa Abdullah ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Mycobacterium tuberculosis infection is the result of large number of morbidity and mortality worldwide. Saudi Arabia has an incidence rate ranged between8.6 and 12.2/100,000. QuantiFERON-TB Gold in-tube is approved to detect latent tuberculosis infection and TB disease. We conduct this study to estimate the prevalence of latent Tuberculosis in healthy population in Saudi Arabia and detect the sensitivity, specifi city and positive and negative predictive values for QuantiFERON-TB Gold in-tube. Methods: A cross-sectional study of blood sampling for QuantiFERON-TB Gold intube testing took from healthy blood donor were recruited from blood bank at King Saud University (KSU) and volunteers from Riyadh region, with further contact and follow up for positive results for two years for activation of latent tuberculosis. The study supported by King Saud University and King Abdul-Aziz City for Science and Technology. Project number ARP-245-29. Results: The study consists of 563 participants, their mean age was 34.2±13.17 year, 292 (51.9 %) male and mean BMI was 27.5 ±5.53 kg/m2. 363 (65.6%) had a BCG scar, the contact to the TB patients represented by 33 (5.9%) and 7 (1.2%) had a previous TB infection. Positive result for QFT-GIT was found in 72 (12.8%) participants, 48 (69.6%) of them had a BCG scar, only 2 (2.8%) and 4 (5.6%) had history of previous TB and contact of TB patients, respectively. Our study showed sensitivity of 90.62% (75-98%) and specificity of 91.53% (89-94%) with a positive predictive value of 39.19% (28-51%) and negative predictive value of 99.39% (98-99.9%) Conclusions: In face of reduction of the limits of other technique, QFT-GIT is not a signifi cant in diagnosis of latent TB. However, it is signifi cant in ruling out the presence of disease.
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