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Characterization and comparison of chitosan/PVP and chitosan/TiO<sub>2</sub> films
( Le Thi Kim Tram ),김주승,임진익,이우걸 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
Burn wound dressings have played significant roles in daily clinical practices. The adhesive nature of chitosan, together with their antifungal and bactericidal characters, and their permeability to oxygen, is a very important property associated with the treatment of skin wounds and burns. This study investigated the physical and functional properties of chitosan films prepared with poly(N-vinyl-2-pyrrolidone) (PVP) and titanium dioxide (TiO₂) in wound healing dressing. The incorporation of PVP or TiO₂ in chitosan film could significantly reduce production price with no effect on functionality of the films. Our results indicated that the CHT/PVP/TiO₂ can be potentially applied as a wound dressing.
( Le Thi Kim Tram ),이우걸 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.0
With the purposes to improve the physico-chemical performance of chitosan-gelatin films on the cell strategies and surface properties, the excellent biodegradable synthetic materials with various ratios of chitosan, gelatin and calcium phosphate were prepared. Based on the results of this study, contact angle measured after coating calcium phosphate on chitosan/gelatin film decreased indicating that the wettability of the film was increased. In addition, fibroblast (NIH3T3) attachment and growth on the films were significantly enhanced on the composite films. Modification of chitosan, gelatin and calcium phosphate films resulted in a substantial increase in fibroblast viability. Further studies describing the new synthesized biodegradable materials possessed good flexibility for cellular attachment, spreading, and proliferation, which may promise broad prospects in biomedical fields such as promote wound healing and antibacterial activity.
Study on the electrostatic effects on the interfacial phenomena of proteins
( Le Thi Kim Tram ),김주승,김응석,임진익,이우걸 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
The interfacial behavior of biomolecules, proteins in particular, characterizes a variety of biological phenomena. The adsorbed proteins can modulate the cellular responses including adhesion, proliferation, and differentiation. Therefore, adsorptive behavior of proteins can be one of the most important factors which can determine the success of implant materials. In this study, we investigated the charge effect on protein adsorption using positively and negatively charged proteins. In particular, sequential adsorption was performed in order to analyze the effect of pre-adsorbed protein molecules on incoming protein adsorption. The effect of the surface hydrophilicity on protein adsorption was also examined. Relative amount of adsorbed protein was quantified using FT-IR and surface hydrophilicity was determined using goniometer.
Effect of association of drug into ceramic compounds on cellularresponses
( Le Thi Kim Tram ),김주승,정은진,이수희,이준석,이우걸 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0
Ceramic materials are widely used as biomaterials. However, ceramic processing conditions are harsh to associate with organic substances, i.e. drugs. Therefore, it is rare to associate ceramic biomaterials withorganic drugs for bioactivity improvement. Consequently, polymers have been major means as drug carriers. In this study, we investigated the association of drug with ceramic compound and examined the effects of the drug-association on cellular responses, particularly bonerelated cell. Drug association was analyzed and cellular responses including adhesion, proliferation, and differentiation were examined. Our result demonstrated that the drug was successfully associated with ceramic compound and strongly up-regulated cellular responses. We expect this technique can be utilized for the reinforcement of ceramic biomaterials.
( Le Thi Kim Tram ),이우걸 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0
This work aims at studying the effect of the modified composite films on the cell strategies and surface properties. The excellent biodegradable synthetic materials with various ratios of chitosan, gelatin and calcium phosphate were prepared, using a solvent casting method from a blend of chitosan, gelatin and calcium phosphate. The model films casted from the initial components were also studied. Contact angle measured after coating calcium phosphate on chitosan/gelatin film decreased indicating that the wettability of the film was increased. In addition, fibroblast (NIH3T3) attachment and growth on the films were significantly enhanced on the composite films. Modification of chitosan, gelatin and calcium phosphate films resulted in a substantial increase in fibroblast viability. The results show that new synthesized biodegradable materials possessed good flexibility for cellular attachment, spreading, and proliferation, which may promise broad prospects in biomedicals fields such as promote wound healing and antibacterial activity.
( Le Thi Kim Tram ),이우걸,정은진,이수희,김주승,임진익 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0
Burn wound dressings have played significant roles in daily clinical practices. The adhesive nature and permeability to oxygen together with antifungal and bactericidal characters of chitosan is a very important property associated with the treatment of skin wounds and burns. This study investigated the physical and functional properties of chitosan films prepared with poly(N-vinyl-2-pyrrolidone)(PVP) and titanium dioxide (TiO2) in wound healing dressing. The incorporation of PVP or TiO₂ in chitosan film significantly can reduce the production price with no effect on chitosan functionality. The results indicated that the new synthetic materials were acheived promote cell growth, increase the viability of the cells, the proliferation of fibroblast, anti-inhibit the activity of the bacteria. Therefore, it is suggested that the treament with CHT/PVP/TiO2 composite thin film will be effective alsoin patients with burns and other skin wounds.
Biomaterials based on CHT/PVP/TiO<sub>2</sub>/CAP in wound dressing applications
( Le Thi Kim Tram ),김주승,임진익,이우걸 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
Wound dressing is one of the most promising medical applications. This research evaluated a novel of chitosan blends with different concentrations of PVP, titanium dioxide, calcium phosphate for medical applications to wound healing. Our results demonstrated that the newly synthesized dressing achieved the enhanced cell growth, increase in the vitality of the cells, the promoted proliferation of fibroblast, and anti-inhibitory activity on bacteria, and provided the assistance in forming a chitosan film PVP. Therefore, it is suggested that the treatment with CHT/PVP/TiO₂ composite thin film can be effective in skin burns and wounds. It could be promising option for wound healing treatment.