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Rao, Kummara Madhusudana,Kumar, Anuj,Suneetha, Maduru,Han, Sung Soo Elsevier 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.112 No.-
<P><B>Abstract</B></P> <P>In this work, we propose biofriendly in-situ preparation method of Au NPs (hexagonal and rod-shape structures) in the lumen as well as the surface cage of biocompatible halloysite nanotubes (HNTs) using curcumin (CUR) as anticancer drug and subsequently coating with bio-adhesive chitosan (CS) as a polysaccharide. The formation of Au NPs and their interactions with CUR and CS exist in the HNTs has been characterized by FTIR, XRD, XPS, STEM techniques. Interestingly, Au NPs showed longitudinal plasmon resonance bands at 760 and 980 nm that indicate the near-infrared (NIR) responsive property of hybrid nanoparticles. Rod shape and hexagonal structures of Au NPs were produced as confirmed by TEM images. The loading efficiency of CUR was found as much as 12%. Importantly, more CUR release was achieved under acidic conditions (pH 5.5) than basic conditions (pH 7.4). The anticancer potential of HNT hybrid nanoparticles on MCF-7 cancer cells was studied and showed efficient anticancer activity under intracellular tumor cell environment (pH 5.5) than extracellular conditions (pH 7.4). Moreover, the developed HNT hybrid nanoparticles consisting of Au NPs (NIR responsive property) and pH-responsive CUR release could make it suitable for cancer cell-targeted drug delivery platform with NIR-imaging.</P>
Rao, Kummara Madhusudana,Suneetha, Maduru,Zo, Sunmi,Duck, Kim Hyun,Han, Sung Soo Elsevier 2019 Carbohydrate Polymers Vol.223 No.-
<P><B>Abstract</B></P> <P>In this study, hyaluronic acid-zinc oxide ((HA-ZnO) nanocomposite hydrogels (NCHs) were prepared by one-pot synthesis method. In particular, one-pot process facilitated the rapid formation of a network structure of HA hydrogel with 1,4-butanediol diglycidyl ether (BDDE) crosslinker followed by the formation of ZnO nanobelt-like structures, which was confirmed using <SUP>1</SUP>H NMR, FTIR, XRD, and SEM techniques. The rheology, swelling, and biodegradable behavior were assessed. The cell proliferation and adhesion were retained (similar to HA hydrogels) after the incorporation of ZnO in the hydrogels treated with Human Skin Fibroblasts (CCD-986k). An examination of the hemostatic property of the hydrogels confirmed the good hemostatic properties of HA-ZnO NCHs. An antibacterial study against both gram-positive <I>Staphylococcus aureus</I> and gram-negative <I>Escherichia coli</I> bacteria revealed their excellent antibacterial efficacy. However, the antiadhesive bacterial property of HA hydrogels was slightly reduced with the incorporation of ZnO. In summary, one-pot synthesis of ZnO nanobelt-like structures in HA hydrogels may be excellent candidates for cell adhesive, hemostatic, and antibacterial materials for wound dressing applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hyaluronic acid-zinc oxide (HA-ZnO) hydrogels were prepared by one-pot method. </LI> <LI> The one-pot process facilitated the formation ZnO nanobelt-like structures. </LI> <LI> Cell proliferation and adhesion were retained (similar to HA hydrogels) for HA-ZnO. </LI> <LI> The hydrogels are good hemostatic with excellent antibacterial properties. </LI> <LI> HA-ZnO hydrogels may be excellent candidates for wound dressing applications. </LI> </UL> </P>
Application of xanthan gum as polysaccharide in tissue engineering: A review
Kumar, Anuj,Rao, Kummara Madhusudana,Han, Sung Soo Elsevier 2018 Carbohydrate Polymers Vol.180 No.-
<P><B>Abstract</B></P> <P>Xanthan gum is a microbial high molecular weight exo-polysaccharide produced by <I>Xanthomonas</I> bacteria (a Gram-negative bacteria genus that exhibits several different species) and it has widely been used as an additive in various industrial and biomedical applications such as food and food packaging, cosmetics, water-based paints, toiletries, petroleum, oil-recovery, construction and building materials, and drug delivery. Recently, it has shown great potential in issue engineering applications and a variety of modification methods have been employed to modify xanthan gum as polysaccharide for this purpose. However, xanthan gum-based biomaterials need further modification for several targeted applications due to some disadvantages (e.g., processing and mechanical performance of xanthan gum), where modified xanthan gum will be well suited for tissue engineering products. In this review, the current scenario of the use of xanthan gum for various tissue engineering applications, including its origin, structure, properties, modification, and processing for the preparation of the hydrogels and/or the scaffolds is precisely reviewed.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Xanthan gum is a microbial high molecular weight exo-polysaccharide. </LI> <LI> It has excellent biocompatibility and pseudo-plastic behavior. </LI> <LI> Shear-thinning and gelling behaviors of XG are more beneficial in tissue engineering. </LI> <LI> Recent trends on XG-based biomaterials in tissue engineering are reviewed. </LI> <LI> It shows a quite promising future as a biopolymer in tissue engineering. </LI> </UL> </P>
Kumar, Anuj,Rao, Kummara Madhusudana,Han, Sung Soo Elsevier 2018 Carbohydrate Polymers Vol.193 No.-
<P><B>Abstract</B></P> <P>Polyacrylamide-sodium carboxymethylcellulose (PMC) hybrid hydrogels reinforced with graphene oxide (GO) and/or cellulose nanocrystals (CNCs) were prepared <I>via in situ</I> free-radical polymerization. In this work, GO nanosheets were freshly synthesized by modified Hummer’s method alongwith the aqueous suspension of CNCs by acid-hydrolysis. In addition, the effect of GO content (1.5 wt%) and CNCs (from 2.5 wt% to 10.0 wt%) was investigated in these quaternary hydrogels. The results showed good pseudo-plastic behavior, self-healing ability, mechanical performance, and shape-recovery behavior of the hybrid hydrogels reinforced with GO and CNCs content. PMC-GO1.5/CNCs10.0 hybrid hydrogel showed 110.5 kPa as compressive strength and stiffness value of 887.7 N/m (at 30% strain). Moreover, the synergistic effect of both GO and CNCs as nanoreinforcements in hydrogels provides a new point of view for the preparation of hybrid hydrogels having exceptional structural and mechanical properties. As-obtained hybrid hydrogels may have potential application in tissue engineering for tunable mechanical properties.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Mechanically viscoelastic hybrid hydrogels are achieved using One-Pot synthesis. </LI> <LI> Multifunctional synergistic GO/CNCs crosslinking is improved. </LI> <LI> A quaternary-network hydrogel reaction mechanism is presented. </LI> <LI> Excellent rheological and mechanical properties are observed. </LI> <LI> Shape-recovery and self-healing behavior are advantageous for tissue engineering. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Nagella Siva Gangi Reddy,Kummara Madhusudana Rao,Kummari Subba Venkata Krishna Rao,하창식 한국고분자학회 2016 Macromolecular Research Vol.24 No.6
This paper describes the synthesis of a new chelating poly(acrylamide-co-dimethylaminoethyl methacrylate- co-1-acryloyl-3-phenyl thiourea) (PAPDM) hydrogel. The PAPDM hydrogels were prepared by the simple free radical polymerization of monomers acrylamide, dimethylamino ethyl methacrylate and 1-acryloyl-3-phenyl thiourea. The free radical initiator used for this study was ammonium persulphate and the cross-linker was ethylene glycol di methacrylate. The swelling study of the PAPDM hydrogels were performed in the aqueous environment to calculate the morphological parameters, such as the volume fraction in a swollen gel (v2m), polymer-solvent interaction parameter (χ) and molecular weight between the crosslinks (Mc). These hydrogels were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry and scanning electron microscopy. Further these chelating hydrogels were investigated for the removal of rare earth metal ions (samarium and terbium) from aqueous environments by varying the adsorption time, adsorbate concentration and monomer ratio. The adsorption time data for samarium and terbium were fitted to two simple kinetic models, pseudo-first and pseudo-second-order, and tested to examine the adsorption mechanisms. The kinetic parameters were calculated. The equilibrium data was fitted well to the Langmuir and Freundlich models.