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- 저자 : ( Jianlin Yang ) (검색결과 4 건)
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Viscoplastic behavior of AA7075 aluminum alloy at high strain rate
Keguo Zhang,Yang Cao,Jianlin An,Keyi Wang 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.12
The flow stress increases with the increase in strain rate. This phenomenon is the strain rate effect of plastic deformation. Hopkinson experiment (10 2 –10 4 s −1 ) and metal cutting experiment (> 10 4 s -1 ) of AA7075 aluminum alloy were conducted at room temperature (20 °C) to better understand the strain rate effect of materials in a wider strain rate range. Results show that when the strain rate is in the range of 1×10 4 –1.3×10 4 s −1 , the plastic deformation control mechanism of AA7075 aluminum alloy begins to change from thermal activation mechanism to dislocation damping mechanism. The viscous behavior of material deformation during cutting is shown as linear correlation between strain rate and stress. Analysis of the deformation degree of cutting chips reveals that insufficient times for deformation and softening are the main reasons for the strain rate effect.
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( Mulan Wei ),( Xujie Liu ),( Chunyu Cao ),( Jianlin Yang ),( Yafeng Lv ),( Jiaojiao Huang ),( Yanlin Wang ),( Ye Qin ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.11
Recent studies showed that the PD-1/PD-L1 checkpoint blockade is a dramatic therapy for melanoma by enhancing antitumor immune activity. Currently, major strategies for the PD-1/PD-L1 blockade have mainly focused on the use of antibodies and compounds. Seeking an alternative approach, others employ endogenous proteins as blocking agents. The extracellular domain of PD-1 (ePD1) includes the binding site with PD-L1. Accordingly, we constructed a PD-1-based recombinantly tailored fusion protein (dFv-ePD1) that consists of bivalent variable fragments (dFv) of an MMP-2/9-targeted antibody and ePD1. The melanoma-binding intensity and antitumor activity were also investigated. We found the intense and selective binding capability of the protein dFv-ePD1 to human melanoma specimens was confirmed by a tissue microarray. In addition, dFv-ePD1 significantly suppressed the migration and invasion of mouse melanoma B16-F1 cells, and displayed cytotoxicity to cancer cells in vitro. Notably, dFv-ePD1 significantly inhibited the growth of mouse melanoma B16-F1 tumor cells in mice and in vivo fluorescence imaging showed that dFv-ePD was gradually accumulated into the B16-F1 tumor. Also the B16-F1 tumor fluorescence intensity at the tumor site was stronger than that of dFv. This study indicates that the recombinant protein dFv-ePD1 has an intensive melanoma-binding capability and exerts potent therapeutic efficacy against melanoma. The novel format of the PD-L1-blocked agent may play an active role in antitumor immunotherapy. [BMB Reports 2018; 51(11): 572-577]
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Wang, Huiyu,Qiao, Jian,Gao, Mingyu,Yang, Ying,Li, Kai,Wang, Jianlin,Tian, Yong,Xu, Tong Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.10
Endothelin-1 (ET-1) is an important factor in regulation of cardiovascular tone in humans and mammals, but the biological function of ET-1 in the avian vascular system has not been determined. The purpose of this study was to characterize the role of endogenous ET-1 in the vascular system of poultry by investigating the effect of endothelin A receptor ($ET_AR$) antagonist BQ123 on the femoral artery pressure (FAP) and the pulmonary artery pressure (PAP) in broiler chickens. First, we found that plasma and lung homogenate ET-1 levels were both increased with age over the seven weeks life cyccle of broiler chickens. Second, 60 min after intravenous injection, BQ123 ($0.4{\mu}g\;kg^{-1}$ and $2.0{\mu}g\;kg^{-1}$, respectively) induced a significant reduction in FAP and PAP (p<0.05). Third, chronic infusion of BQ123 ($2.0{\mu}g\;kg^{-1}$ each time, two times a day) into abdominal cavities led to significant decrease in systolic pressure of the femoral (p<0.05) and pulmonary arteries (p<0.01) in broiler chickens at 7 and 14 days after treatment. Taken together, the $ET_AR$ antagonist BQ123 lead to a significant reduction of FAP and PAP, which suggests that endogenous ET-1 may be involved in the maintenance and regulation of systemic and pulmonary pressure in broiler chickens.
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Ling Mao,Yuankai Li,Chao Pan,Jianlin Yang,Qin Hu,Yuncong Zheng,Jinbin Zhao 전력전자학회 2024 JOURNAL OF POWER ELECTRONICS Vol.24 No.4
Parallel three-level neutral point clamped (3L-NPC) inverters are widely used in power conversion applications, such as new energy generation and high voltage inverters. However, the zero-sequence circulating current (ZSCC) between two inverters degrades the whole performance of the system. To suppress the ZSCC in parallel inverters and improve the quality of output current, this study proposes an MPC strategy based on the virtual location vector. First, to reduce the computational burden of MPC, the virtual location vector is constructed by the output current of two inverters so that the control of the parallel inverters is similar to that of a single inverter. Then, the virtual location vector is obtained by using the direct power control method. Finally, the sets of candidate voltage vectors for MPC are determined on the basis of this reference voltage vector and the magnitude of ZSCC. Moreover, the optimal vectors calculated by MPC are assigned to the two inverters. Compared with the traditional MPC strategy, the MPC strategy proposed in this study has better steady state and transient performance with less computational burden. The proposed method is validated in simulation and experimental platforms.
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