http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Harsha Pokkalla ),( Kishalve Pethia ),( Benjamin Glass ),( Jennifer Kaplan Kerner ),( Ling Han ),( Catherine Jia ),( Ryan Huss ),( Mar-ianne Camargo ),( Kathryn Kersey ),( Chuhan Chung ),( G. Mani S 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Fibrosis is the primary determinant of disease progression in patients with nonalcoholic steatohepatitis (NASH), but the prognostic impact of other histological features is unclear. We used a machine learning(ML) approach to identify novel morphologic features and associations with disease progression in NASH patients with F3/4 fibrosis. Methods: Biopsies from 644 patients screened in phase3 trial of selonsertib (STELLAR-4) were scored by a central pathologist( CP) according to the NASH CRN and Ishak staging systems. The PathAI research platform(PathAI, Boston, MA) was trained a convolutional neural network(CNN) with >68,000 annotations (e.g. steatosis, ballooning, lobular/portal inflammation) collected from 75 board-certified pathologists on images of H&E and trichrome(TC) stained slides. For staging fibrosis, CNN models were trained using slide-level pathologist scores to recognize unique patterns associated with each stage within fibrotic regions of TC images. 202 features were extracted from biopsy images from patients (F3-F4) enrolled in the STELLAR trials. Cox regression was used to identify associations between these features with progression to cirrhosis in F3 patients, and liver-related events (e.g. decompensation, transplantation, death) in F4 patients. Results: 1526 NASH patients with F3-F4 fibrosis (median age 59 yrs, 73% diabetic, 52% F4) were included. During a median follow-up of 16.5 mos, 14.5% (105/726) of F3 patients progressed to cirrhosis, and over 15.9 mos, 2.8% (22/800) of F4 patients had liver-related events. Progression to cirrhosis was associated with greater area of Ishak 6 fibrosis and portal inflammation (Figure). Similar associations were observed in F4 patients, with hepatocellular ballooning and clinical events. In F3, a greater proportion of area of Ishak 1 fibrosis and steatosis were associated with a reduced risk of progression. In F4, area of steatosis was similarly protective, while proportion of Ishak Stage 1 Fibrosis over Ishak scored area trended towards protective. Conclusions: Liver histological evaluation using ML approach identified novel features associated with progression in NASH patients with advanced fibrosis. These data support the utility of ML approaches to evaluation of liver histology as endpoints in NASH clinical trials.
Modeling of Mechanical Behavior of Microcantilever due to Intrinsic Strain during Deposition
Kim Sang-Hyun,Mani Sathyanarayanan,Boyd James G. IV The Korean Society of Mechanical Engineers 2006 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.20 No.10
A model of mechanical behavior of microcantilever due to intrinsic strain during deposition of MEMS structures is derived. A linear ordinary differential equation is derived for the beam deflection as a function of the thickness of the deposited layer. Closed-form solutions are not possible, but numerical solutions are plotted for various dimensionless ratios of the beam stiffness, the intrinsic strain, and the elastic moduli of the substrate and deposited layer. This model predicts the deflection of the cantilever as a function of the deposited layer thickness and the residual stress distribution during deposition. The usefulness of these equations is that they are indicative of the real time behavior of the structures, i.e. it predicts the deflection of the beam continuously during deposition process.
Modeling of Mechanical Behavior of Microcantilever due to Intrinsic Strain during Deposition
Sang-Hyun Kim,Sathyanarayanan Mani,James G. Boyd Ⅳ 대한기계학회 2006 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.20 No.10
A model of mechanical behavior of microcantilever due to intrinsic strain during deposition of MEMS structures is derived. A linear ordinary differential equation is derived for the beam deflection as a function of the thickness of the deposited layer. Closed-form solutions are not possible, but numerical solutions are plotted for various dimensionless ratios of the beam stiffness, the intrinsic strain, and the elastic moduli of the substrate and deposited layer. This model predicts the deflection of the cantilever as a function of the deposited layer thickness and the residual stress distribution during deposition. The usefulness of these equations is that they are indicative of the real time behavior of the structures, i.e. it predicts the deflection of the beam continuously during deposition process.
A New Marginal Color Image Water Marking Method based on Logical Operators
B. Vijaya Kumar,M.Radhika Mani,G. Roseline NesaKumari,Dr. V. Vijaya Kumar 보안공학연구지원센터 2009 International Journal of Security and Its Applicat Vol.3 No.4
Image hiding is a technique that embeds the images into a cover image which makes the watermarks imperceptible so that they can be securely transmitted to the receiver. In this paper, an effective color image watermarking method based on the marginal strategy is proposed. The method uses logical operators like AND and XOR on the nibble to hide the image with in the cover image. To test the robustness of the stego image the present method is applied on different kinds of cover images and the resulting perceptual quality is good.
( Brunetto ),( Carla Coffin ),( Audrey Lau ),( Shuyuan Mo ),( John F. Flaherty ),( Anuj Gaggar ),( G Mani Subramanian ),( Mindie H. Nguyen ),( Selim Gurel ),( Alexander Thompson ),( Edward J. Gane ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Suppression of the HBV in women of childbearing potential (WOCBP) has important implications in preventing transmission of HBV from mother to infant. Antiviral therapy that reduces HBV DNA to < 2x105 IU/mL at delivery in mothers can substantially reduce the risk of perinatal transmission. We evaluated the viral kinetics of TAF and TDF in WOCBP. Methods: : In two Phase 3 studies (HBeAg positive and negative patients), 1301 patients (37% female) were randomized (2:1) to receive TAF 25 mg QD or TDF 300 mg QD. All patients were required to have HBV DNA >2x104 IU/mL at screening and serum ALT >2 times AASLD criteria.WOCBP were defined as nonmenopausal females 18 years or older without history of hysterectomy, bilateral oophorectomy, or ovarian failure. For this subanalysis, patients were stratified by baseline HBV DNA levelsand the endpoints were virologic suppression to HBV DNA <29 IU/mL or < 2x105 IU/mL. Results: 365(76%) female were identified as WOCBP with 118 (32%) having HBV DNA >1x108 IU/mL at baseline. Suppression rates were generally similar between TAF and TDF groups and within viral load strata for HBeAg positive and negative patients. After 12 weeks of treatment with TAF or TDF, 77% of WOCBP with baseline HBV DNA <2x105 IU/mL had full suppression to <29 IU/mL compared to 1% of those at the highest baseline viral load (Figure A). By Week 24, 54% of all WOCBP had achieved complete viral suppression. Of WOCBP with baseline viral load ≥2x105 IU/mL (n=305), 76%, 89%, and 93% achieved viral load reduction to <2x105 IU/mL by Weeks 4, 8, and 12, respectively (Figure B). Conclusions: After 12 weeks of treatment the majority of WOCBP had HBV DNA to <2x105 IU/mL. In women with higher baseline viral loads, longer treatment duration may be necessary to achieve viral suppression below recommended thresholds.
( Young Suk Lim ),( Henry L. Chan ),( Scott Fung ),( Wai Kay Seto ),( Ed Gane ),( John F. Flaherty ),( Vithika Suri ),( Lanjia Lin ),( Anuj Gaggar ),( G Mani Subramanian ),( Wan Long Chuang ),( Kosh A 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: TAF has shown less bone and renal effects with similar efficacy rates compared to TDF in two Phase 3 studies after 48 weeks treatment. Here, we evaluate patients completed 96 weeks of double blind(DB) treatment with TAF or TDF and have switched to open label(OL) treatment with TAF to determine changes in bone mineral density(BMD), creatinine clearance(CrCl), and the maintenance of viral suppression. Methods: Immune active CHB patients who were HBeAg negative (Study 0108; N=425) or HBeAg positive (Study 0110; N=873) were randomized to and treated with TAF 25 mg QD or TDF 300 mg QD. A subset of patients (N=200 in Study 0108 and N=340 in Study 0110) in these ongoing 8 year studies had completed 96 weeks of DB treatment with TAF or TDF and switched to OLTAF at Week 96 analysis. Dual energy X-ray absorptiometry (DXA) scans were evaluated every 24 weeks as were serial assessments of CrCl and viral suppression. Results: CrCl improved significantly in patients switched from DB TDF to OL TAF at Week 120 compared to Week 96 (N=117, mean (SD) change=+2.43 (12.81) ml/min, p=0.04); and remained stable in those previously receiving TAF (Figure A). BMD also showed improvement at Week 120 from Week 96 among patients switched from DB TDF to OL TAF (hip: N=58, mean (SD) % change=+0.71% (1.43), p=0.0004; spine: N=60, mean (SD) % change=+1.41% (2.30), p<.0001). BMD changes in hip and spine for DB TAF patients entering the OL TAF period were relatively stable (Figure B). Compared to results at Week 96, high rates of virologic control were maintained across subjects in both studies during the OL period. Conclusions: Patients who switched from TDF to TAF treatment demonstrated rapid improvements in BMD and CrCl within the first 24 weeks of treatment, and virologic control was maintained.