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      • Poster Session:PS 0172 ; Endocrinology : Laboratory Monitoring of Osseous Metabolism Parameters in Adults with Beta-Thalassaemia

        ( Christina Stefanidou ),( Efterpi Bogia ),( Christina Botziori ),( Eleftheria Nakou ),( Asimoula Koteli ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        Background: The correlation between vitamin D, parathormone (PTH), Calcium (Ca), Phosphorus (P), Magnesium (Mg) and osteopenia or osteoporosis in patients with Thalassemia major. Methods: 43 thalassaemics patients 24-63 years old were included in the study. 31 of them were female and 12 male. 3 females were in menopause. 25 females were treated with oestogens and 3 diagnosed with hypogonadism. 3 males were diagnosed with hypogonadism, 5 were treated with testosterone and 4 had no treatment. The levels of Ca, P, Mg and 25(OH)D were measured with the method of Chemiluminescent Immunoassay (Architect c8000 ABBOTT Laboratories) where PTH with the method of radioimmunoassay RIA. The osseous density of COCCYX and trochanter femoral neck were both recorded via DEXA method. Results: All patients were diagnosed with osseous metabolism disorder either with osteopenia (Tscore from -1 to -2,5) or osteoporosis (Tscore = -2,5).18 of them were recorded with osteoporosis and 25 with osteopenia. In osteoporosis: the average range of 25(OH)D was 27,93 in men/16,3 in women (normal range:20-60,3 ng/ml), of PTH was15,0/23,2 (normal range:10-65 pg/ml), of Ca 8,83/9,0 (normal: 8,4-10,2 mg/dl). In osteopenia the average range of 25(OH)D was respectively 20,56 in men /20,36 in women, of PTH was 39,63 in men /38,33 in women, of Ca 8,71 in men /8,74 in women. Measurements of P and Mg were monitored within normal range. Conclusions: Females with osteoporosis or osteopenia were diagnosed with insuffi cient Vit.D and high levels of PTH. The inverse correlation of Vit.D with PTH occurs when levels of Vit.D were < 20.

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