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RISS 인기검색어
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- 저자 : ( Christina Stefanidou ) (검색결과 3 건)
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( Christina Stefanidou ),( Efterpi Bogia ),( Christina Botziori ),( Eleftheria Nakou ),( Asimoula Koteli ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The correlation between vitamin D, parathormone (PTH), Calcium (Ca), Phosphorus (P), Magnesium (Mg) and osteopenia or osteoporosis in patients with Thalassemia major. Methods: 43 thalassaemics patients 24-63 years old were included in the study. 31 of them were female and 12 male. 3 females were in menopause. 25 females were treated with oestogens and 3 diagnosed with hypogonadism. 3 males were diagnosed with hypogonadism, 5 were treated with testosterone and 4 had no treatment. The levels of Ca, P, Mg and 25(OH)D were measured with the method of Chemiluminescent Immunoassay (Architect c8000 ABBOTT Laboratories) where PTH with the method of radioimmunoassay RIA. The osseous density of COCCYX and trochanter femoral neck were both recorded via DEXA method. Results: All patients were diagnosed with osseous metabolism disorder either with osteopenia (Tscore from -1 to -2,5) or osteoporosis (Tscore = -2,5).18 of them were recorded with osteoporosis and 25 with osteopenia. In osteoporosis: the average range of 25(OH)D was 27,93 in men/16,3 in women (normal range:20-60,3 ng/ml), of PTH was15,0/23,2 (normal range:10-65 pg/ml), of Ca 8,83/9,0 (normal: 8,4-10,2 mg/dl). In osteopenia the average range of 25(OH)D was respectively 20,56 in men /20,36 in women, of PTH was 39,63 in men /38,33 in women, of Ca 8,71 in men /8,74 in women. Measurements of P and Mg were monitored within normal range. Conclusions: Females with osteoporosis or osteopenia were diagnosed with insuffi cient Vit.D and high levels of PTH. The inverse correlation of Vit.D with PTH occurs when levels of Vit.D were < 20.
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( Efterpi Bogia ),( Christina Botziori ),( Christina Stefanidou ),( Pantelis Fytas ),( Eleni Kakasi ),( Asimoula Koteli ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The detection of extractable nuclear antibodies (anti-ENA: Jo-1, Scl-70, SSA/Ro, SSB/La, Sm, Sm/RNP) and anti-ds DNA in sera of patients positive for antinuclear antibodies (ANA). Methods: 1084 sera of patients with autoimmune disorders, collected between September 2010 and August 2012, were tested for ANA and anti-ds DNA, by indirect immunofiuorescence technique (IFA), and for anti-ENA, by enzyme immunosorbent assay (ELISA). Results: 328 out of the 1084 (30,26%) were found ANA positive and 756 (69,74%) ANA negative. The most common pattern for the ANA was the speckled, followed by the homogeneous. In 154 of the positive samples, anti-ds DNA was tested, with 8 cases (5,2%) positive, over 146 (94,8%) negative. 224 samples were evaluated for anti-ENA, with 104 (46,43%) that were found positive and 120 (53,57%) negative. The prevalent anti-ENA was SSA/Ro, that was found in 37 patients (35,57%) and was associated with other antinuclear antibodies in 26 cases (25%). Second in prevalence was Sm/ RNP, isolated in 15 cases (14,42%) and associated with other antinuclear antibodies in 13 patients (12,5%), all of them with coarse speckled nuclear pattern. The remaining 13 samples positive for anti-ENA had other positive antibodies from the panel. Conclusions: The identification of autoantibodies contributes to the diagnosis and prognosis of autoimmune disorders. Especially, the anti-ds DNA are detected only when ANA are positive in SLE suspected cases.
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( Pantelis Fytas ),( Efterpi Bogia ),( Christina Botziori ),( Christina Stefanidou ),( Eleni Kakasi ),( Asimoula Koteli ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: To estimate the frequency of anaerobic bacteria and their susceptibility pattern during an 24 month period. Methods: 1639 specimens were studied retrospectively from empyemas, wounds, soft tissue, bone and joint infections, peritoneal and pleuritic fi uids, blood, stool and other infectious sites. All samples were cultured according to conventional methods in aerobic and anaerobic conditions. Identifi cation of anaerobic isolates was performed by VITEK2-compact (Bio Merieux). Antibiotic susceptibility testing was performed by ATB ANA (Bio Merieux). Results: 86(5,2%) anaerobic bacteria were isolated from 98 anaerobic cultures. 12 anaerobic cultures were polymicrobial. 46(53,4%) strains were Gram(+) anaerobic bacteria (2 Actinomyces spp.,8 Peptostreptococcus spp., 3 Bifidobacterium spp, 3 Propionibacterium Spp, 12 Clostridium spp, 3 finegoldia magna, 1 Lactobacillus gasseri) and 40(46.6%) strains were Gram(-) anaerobic bacteria (7 Bacteroides fragilis, 20 Bacteroides non-fragilis group, 9 Prevotella spp., 4 Veillonella spp. 36 strains were isolated from empyemas/ abscesses, 24 from wounds (soft tissue) infections, 4 from peritoneal fi uid infections, 1 from pleurical, 8 from blood, 1 from joint infection, and 12 from other sites. Susceptibility testing was performed to metronidazole, penicillin, piperacillin-tazobactam, imipenem, cefoxitin, ceftriaxone, clindamycin, tetracycline and erythromycin. Antimicrobial resistance Gram(+) Gram(-) Amoxicillin/Clavoulanic 2.1% 15% Metronidazole 10.8% 2.5% Clindamycin 23.9% 32.5% Cefoxitine 6.5% 25% Imipenem 0% 0% piperacillin-tazobactam 0% 0% Conclusions: 1) Frequency of isolation of anaerobic bacteria in infections was 5.2 % with most common pathogens: Bacteroides spp.(31.3%), followed by Clostridium spp. (13,9%), and Prevotella spp.(10.4%). 2) High resistance to clindamycin, was observed. All isolates were susceptible to imipenem and piperacillin-tazobactam. 3) Gram(-) strains were susceptible 97.5% to Metronidazole and gram(+) were susceptible 97.9% to Amoxicillin/Clavoulanic.
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