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- 검색키워드
- 주제어 : prostaglandin-endoperoxide synthase 2 (검색결과 3 건)
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Liu, Fen,Wei, Wen-Qiang,Cormier, Robert T.,Zhang, Shu-Tian,Qiao, You-Lin,Li, Xin-Qing,Zhu, Sheng-Tao,Zhai, Yan-Chun,Peng, Xiao-Xia,Yan, Yu-Xiang,Wu, Li-Juan,He, Dian,He, Yan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4
Background: The prostaglandin-endoperoxide synthase 2 (PTGS2) and phospholipase A2 group IIA (PLA2G2A) genes encode enzymes that are involved in arachidonic acid and prostaglandin biosynthesis. Dysregulation of both genes is associated with inflammation and carcinogenesis, including esophageal squamous cell carcinoma (ESCC). We therefore hypothesized that there is an association between single nucleotide polymorphisms (SNPs) in these genes and susceptibility to ESCC. Methods: We performed a gene-wide tag SNP-based association study to examine the association of SNPs in PTGS2 and PLA2G2A with ESCC in 269 patients and 269 healthy controls from Taihangshan Mountain, Henan and Hebei Provinces, the rural area of China which has the highest incidence of esophageal cancer in the world. Thirteen tag SNPs in PLA2G2A and 4 functional SNPs in PTGS2 were selected and genotyped using a high-throughput Mass Array genotyping platform. Results: We found a modest increased risk of ESCC in subjects with the PTGS2 rs12042763 AA genotype (OR=1.23; 95% CI, 1.00-3.04) compared with genotype GG. For PLA2G2A, a decreased risk of ESCC was observed in subjects with the rs11677 CT (OR=0.51, 95%CI, 0.29-0.85) or TT genotype (OR=0.51, 95%CI, 0.17-0.96) or the T carriers (CT+TT) (OR=0.52, 95%CI, 0.31-0.85) when compared with the CC genotype. Also for PLA2G2A, rs2236771 C allele carriers were more frequent in the control group (P=0.02). Subjects with the GC (OR=0.55, 95%CI, 0.33-0.93) or CC genotype (OR=0.38, 95% CI, 0.16-0.94) or the C carriers (GC+CC) (OR=0.52, 95%CI, 0.32-0.85) showed a negative association with ESCC susceptibility. Conclusions: Our results suggest that PTGS2 and PLA2G2A gene polymorphisms may modify the risk of ESCC development.
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폐경 여성에서 Prostaglandin-Endoperoxide Synthase 2 (PTGS2) 유전자 다형성과 골밀도의 상관관계
이승훈,고정민,박병래,신형두,김태호,박의균,김신윤,김기수 대한골대사학회 2008 대한골대사학회지 Vol.15 No.1
Objective: Prostaglandin-endoperoxide synthase 2 (PTGS2) is a key regulator of bone metabolism, by mediating osteoclastogenesis, mechanotransduction, bone formation and fracture repair. We examined the association between PTGS2 gene polymorphisms and bone mineral density (BMD) in postmenopausal Korean women. Methods: From the results of previous reports, we selected two polymorphisms, that is, -1329A>G at the promoter region and +6365T>C at the 3’-untranslated region, and we genotyped -1329A>G using single-base extension (SBE) reaction and +6365T>C using TaqMan method. BMD at the lumbar spine and femur neck was measured using dual energy X-ray absorptiometry. Results: Mean age for the subjects was 58.9 years old. The frequencies of the minor alleles of the two polymorphisms were 47.4% for -1329G, and 20.3% for +6365C. Both polymorphisms were in compliance with Hardy-Weinberg equilibrium. PTGS2 -1329A>G didn’t show any significant correlations with the BMD in either site, and PTGS2 +6365T>C didn’t show any significant correlation with lumbar spine BMD. Multiple regression analysis showed that PTGS2 +6365T>C polymorphism was associated with BMD at the femur neck, even after controlling for age, weight, height, and years since menopause (P=0.03). The subjects with C allele had significantly lower femur neck BMD than those with T homozygote. Conclusion: These findings indicate that PTGS2 could be a candidate gene for the determinant for BMD in Korean postmenopausal women.
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Huang, S.Y.,Song, H.L.,Lin, E.-C.,Lee, W.C.,Chiang, J.C.,Tsou, H.L. Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.6
The quality characteristics of semen are important indicators of the fertility of a boar. Development of genetic markers for the semen quality in boars will be beneficial to the improvement of porcine fertility. We investigated the relationship between the polymorphisms of epidermal growth factor (EGF), prostaglandin-endoperoxide synthase 2 (PTGS2) and prolactin receptor (PRLR) genes, and semen quality traits in boars. The genomic DNA of 233 boars (157 Duroc and 86 Landrace) from a central testing station was subjected to genotyping for surveying gene frequency. The EGF, PTGS2 and PRLR genotypes were determined using the restriction fragment length polymorphism method. Thirty-seven normal, mature Duroc boars from an AI center were also genotyped and their semen quality traits were collected. The effect of genotype on semen quality traits was analyzed by the least-squares means method using data corrected for season. The frequencies of the AA genotype of EGF, PTGS2 and PRLR in Duroc boars were 0.14, 0.01 and 0.66, respectively. In Landrace, the frequencies of the AA genotype were 0.03, 0.09 and 0.62, respectively. Boars with the BB genotype in EGF, with the AB genotype in PTGS2 and with the AA genotype in PRLR had significantly better semen quality with a higher percentage of normal sperm and a lower percentage of immature sperm than those with other genotypes. These findings imply that polymorphisms of EGF, PTGS2 and PRLR genes might be used as markers for improving the semen quality of boars.
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