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Mechanisms and Control Strategies of Antibiotic Resistance in Pathological Biofilms
( Ying Luo ),( Qianqian Yang ),( Dan Zhang ),( Wei Yan ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.1
Bacterial biofilm is a community of bacteria that are embedded and structured in a self-secreted extracellular matrix. An important clinical-related characteristic of bacterial biofilms is that they are much more resistant to antimicrobial agents than the planktonic cells (up to 1,000 times), which is one of the main causes of antibiotic resistance in clinics. Therefore, infections caused by biofilms are notoriously difficult to eradicate, such as lung infection caused by Pseudomonas aeruginosa in cystic fibrosis patients. Understanding the resistance mechanisms of biofilms will provide direct insights into how we overcome such resistance. In this review, we summarize the characteristics of biofilms and chronic infections associated with bacterial biofilms. We examine the current understanding and research progress on the major mechanisms of antibiotic resistance in biofilms, including quorum sensing. We also discuss the potential strategies that may overcome biofilm-related antibiotic resistance, focusing on targeting biofilm EPSs, blocking quorum sensing signaling, and using recombinant phages.
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Jing Liu,Yanhang Gao,Xianbo Wang,Zhiping Qian,Jinjun Chen,Yan Huang,Zhongji Meng,Xiaobo Lu,Guohong Deng,Feng Liu,Zhiguo Zhang,Hai Li,Xin Zheng 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.2
Purpose: This study investigated multidrug-resistant (MDR) pathogens and antibiotic strategies of culture-positive spontaneousascitic infection (SAI) in patients with acute decompensated cirrhosis. Materials and Methods: We retrospectively analyzed 432 acute decompensated cirrhotic patients with culture-positive SAI from11 teaching hospitals in China (January 2012 to May 2018). A Cox proportional hazards model analysis was conducted to identifyindependent predictors of 28-day mortality. Results: A total of 455 strains were isolated from 432 ascitic culture samples. Gram-negative bacteria (GNB), gram-positive bacteria(GPB), and fungi caused 52.3, 45.5, and 2.2% of all SAI episodes, respectively. Episodes were classified as nosocomial (41.2%), healthcare-related (34.7%), and community-acquired (24.1%). Escherichia coli (13.4%) and Klebsiella pneumoniae (2.4%) were extendedspectrumβ-lactamase producing isolates. The prevalence of methicillin-resistant Staphylococcus aureus was 1.1%. Ceftazidime,cefepime, aztreonam, and amikacin were recommended as first-line antibiotics agents for non-MDR GNB infections; piperacillin/tazobactam and carbapenems for MDR GNB in community-acquired and healthcare-related or nosocomial infections, respectively;and vancomycin or linezolid for GPB infections, regardless of drug-resistance status. Multivariate analysis revealed days ofhospital stay before SAI, upper gastrointestinal bleeding, white blood cell count, alanine aminotransferase, serum creatinine concentration,total bilirubin, and international normalized ratio as key independent predictors of 28-day mortality. Conclusion: MDR pathogens and antibiotic strategies were identified in patients with acute decompensated cirrhosis with culture-positive SAI, which may help optimize therapy and improve clinical outcomes.
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김재수,김민호,Kim, Jaisoo,Kim, Min-Ho 한국미생물학회 2019 미생물학회지 Vol.55 No.2
대부분의 만성창상(chronic wounds)은 생물막으로 인해 상처 치유시 염증단계를 지속시킨다. 생물막은 항생제(antibiotics)에 대한 저항성을 가지며 침투력을 저하시키고 살균제(biocides)에 대한 내성을 지니며 국소면역반응을 약화시킨다. 또한 생물막은 주변의 조직에 단단히 붙어 있어 제거하는 작업이 매우 어렵다. 그러므로 주변 조직을 손상시키지 않으면서 단단한 생물막을 제거하는 전략은 매우 중요하다. 그 중에 하나가 분산기작을 이용한 생물막의 해체이며 지금까지 많은 연구가 수행되어 왔다. 본 고찰논문에서는 특별히 화학주성, 파지요법, 다당류, 다양한 효소(당분해효소, 단백질분해효소, DNA 분해효소), 계면활성제, 분산신호, 자기유도인자, 조절인자, 억제제 등이 소개되었으며 더 나아가 항생제 치료 및 다른 치료와의 병행을 통한 병합요법도 소개되었다. 앞으로 본 논문에서 제시된 생물막의 분산기작의 지식을 이용하여 만성 창상 감염치료의 가능성이 더 높아지길 기대한다. Most chronic wounds persist in the inflammatory phase during wound healing due to the biofilm. Biofilms are resistant to antibiotics, weakening penetration, resistance to biocides and weakening local immune responses. The biofilm is firmly attached to the surrounding tissues and is very difficult to remove. Therefore, strategies to remove hard biofilms without damaging surrounding tissue are very important. One of possible strategies is dispersal. So many studies have been done to develop new strategies using dispersal mechanisms. In this review paper, especially chemotaxis, phage therapy, polysaccharides, various enzymes (glycosidases, proteases, and deoxyribonucleases), surfactants, dispersion signals, autoinducers, inhibitors were introduced. Combination therapies with other therapies such as antibiotic therapy were also introduced. It is expected that the possibility of treatment of chronic wound infection using the knowledge of the biofilm dispersal mechanisms presented in this paper will be higher.
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Veterinary antibiotics (VAs) contamination as a global agro-ecological issue: A critical view
Kuppusamy, Saranya,Kakarla, Dhatri,Venkateswarlu, Kadiyala,Megharaj, Mallavarapu,Yoon, Young-Eun,Lee, Yong Bok Elsevier 2018 Agriculture, ecosystems & environment Vol.257 No.-
<P><B>Abstract</B></P> <P>Veterinary antibiotics (VAs) are used worldwide in animal farming as drugs to treat or prevent diseases and serve as feed additives. VAs are usually poorly sorbed in the animal gut, and the majority are excreted unchanged or as their recalcitrant metabolites in feces and urine. More importantly, animal wastes are frequently employed in agriculture as a supplement to fertilizer, raising a major international concern about the potential impacts of VAs on agro-ecosystems. Increasing use of these manures in agriculture is thus posing a threat in the form of rapid increase in antibiotic resistance. The current review critically summarizes available literature on the global consumption, exposure pathways, occurrence, fate and environmental effects of VAs in manure-fertilized agricultural soils. Recognizing the importance of the issue of VA resistance in the environment, we focused on the increased abundance and transferability of VA resistance determinants, highlighting details as to how they contribute to the change in human microbiome. Notably, existing regulations and research gaps in association with the spread of VAs and their resistance due to manure application in agricultural fields are also outlined. Finally, we highlight the areas that future research should prioritize and propose certain strategies that could help curtail VAs occurrence and the danger they pose to agro-ecosystems.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Veterinary antibiotics (VAs) in manure pose serious threats to agro-ecosystems. </LI> <LI> Fate and impact of VAs in manure-fertilized agricultural soils are not well understood. </LI> <LI> Regulations for reducing the use and spread of VAs in the environment are limited. </LI> <LI> Research on VAs occurrence and their adverse effects can lead to practical benefits. </LI> <LI> Systematic management strategies to limit spread of VAs have been proposed. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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