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RISS 인기검색어
- 검색키워드
- 주제어 : Thermoneutrality (검색결과 4 건)
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Thermoneutral Housing Exacerbates Liver Fibrosis In Mice
( Nga Thi Ha ),( Ho Yeop Lee ),( Hyon-seung Yi ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Thermoneutral condition has been had a significant impact on metabolic studies. The roles of brown adipose tissue (BAT) on metabolic disease including obesity or fatty liver is receiving increasing attention. Here, we investigated the impact of thermoneutral condition on hepatic fibrosis as well as the contribution of BAT on regulation liver fibrosis in mice. Methods: In this study, we used carbon tetrachloride (CCl4) induced liver fibrosis mouse model and hepatic stellate cells isolated from mice in order to checked fibrotic marker in mice livers housed under room temperature and thermoneutral condition for three weeks. We also compared the changes in the population of hepatic immune cells and the deposition of collagen in mice livers between two kinds of housing conditions. Furthermore, we investigated the effect of secreted factors from brown adipocytes-conditioned media on hepatic stellate cells (HSC) activation process. Results: Serum levels of liver injury and the expression of Col1a1, Acta2 and inflammatory cytokines were up-regulated in the liver of mice under thermoneutral condition compared to room temperature. Moreover, inactivation of BAT by thermoneutrality aggravated hepatic collagen deposition as well as promoted the activation of hepatic stellate cells during CCl4-induced liver fibrogenesis. In consistent with these findings, we also found that the population of infiltrating liver immune cells and pro-inflammatory cytokine-producing T cells was significantly increased in thermoneutral housing mice livers. Treatment of brown adipocytes-conditioned media attenuated HSC activation through down-regulated expression of a-SMA at day 4, day 7 and day 10 cultured HSC. Conclusions: These results suggest that BAT inactivation by thermoneutrality contributes to the activation of pro-inflammatory and pro-fibrotic pathways in CCl4-induced liver fibrogenesis. Secreted factors released from BAT have potential roles on inhibiting HSC activation. Thus, BAT-liver axis may serve as a potential therapeutic target for liver fibrosis.
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Aquatic Exercise at Thermoneutral Water Temperature Enhances Antitumor Immune Responses
이보애,김건아,조유나,이병혁,신용일,홍창완 대한면역학회 2019 Immune Network Vol.19 No.2
Despite the broad rehabilitative potential of aquatic exercises, the relationship between aquatic exercise and the immune system has not been fully elucidated to date. In particular, there are few specific and delicate immunological approaches to the effect of water temperature on immunity. Thus, we examined the effect of water temperature on immunity during aquatic exercise. The animal tumor model was adopted to examine the impact of aquatic exercise at thermoneutral temperature (TT; 29°C) on immunity compared with aquatic exercise at body temperature (BT; 36°C). Tumor-bearing mice were made to swim in TT water or in BT water for 3 wk and immune cells and their functional activity were analyzed using FACS. Tumor growth was significantly suppressed in mice that exercised in TT than in BT water. The tumor control correlated with the increased number of NK (2-fold), γδT cells (2.5-fold), NKT (2.5-fold), and cytotoxic CD8+ T cells (1.6-fold), which play a critical role in anti-tumor immune responses. Furthermore, the functional activity was dramatically improved in the TT group, showing enhanced production of IFNγ in CD8+ T cells compared with the BT group. This study demonstrates that aquatic exercise in TT water may improve protective immune responses more effectively than in BT water. Although the effects of water temperature on immune function need further verification in humans, this study suggests that water temperature in human hydrotherapy may be important for improving immune function.
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