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- 주제어 : Lindera erythrocarpa Makino (검색결과 4 건)
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비목나무 (Lindera erythrocarpa Makino) 껍질에서 분리한 신규화합물 (Jeju-Erythrane)의 멜라닌 생합성 억제 효과
강민철(Min-Chul Kang),고려경(Ryeo Kyeong Ko),김수경(Su-Gyeong Kim),최호민(Ho-Min Choi),진영준(Yeong-Jun Jin),한종헌(Jong-Heon Han),김봉석(Bong-Seok Kim),이남호(Nam Ho Lee),김기옥(Gi-Ok Kim) 한국생물공학회 2010 KSBB Journal Vol.25 No.4
본 연구는 제주도에서 자생하는 비목나무 (Lindera erythrocarpa) 껍질에서 분리 · 동정한 신규화합물 (Jeju-Erythrane)의 항산화 활성 및 B16F10 mouse melanoma 세포에서의 tyrosinase와 멜라닌 생합성의 억제효과를 확인하여, 유용자원으로서 미백 및 기능성 화장료로의 산업적 활용 가능성이 있는지 알아보고자 시행하였다. 실험 결과, 신규화합물인 Jeju-Erythrane의 항산화 활성은 확인되지 않았고, B16F10 세포에서 tyrosinase와 멜라닌 합성을 농도 의존적으로 억제하는 것으로 밝혀졌으며, tyrosinase와 TRP-1 유전자의 단백질 및 mRNA 발현양도 농도 의존적으로 감소함을 보였다. 하지만, TRP-2 단백질과 mRNA는 농도에 관계없이 일정하게 발현하는 것을 알 수 있었다. 따라서, 본 연구결과는 비목나무 (Lindera erythrocarpa) 껍질에서 분리 · 동정한 신규화합물 (Jeju-Erythrane)이 미백 관련 기능성 소재로서의 활용가치가 있음을 보여준다. In this study, a new compound, 1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)-1-methoxy-3-phenylpropane; (Jeju-Erythrane) was isolated and identified from the bark of Lindera erythrocarpa Makino. Also, we investigated the effects of Jeju-Erythrane on alpha melanocyte-stimulating hormone (MSH)-induced melanogenesis in mouse B16F10 melanoma cells. The new compound dose dependently inhibited the tyrosinase activity and melanin synthesis in B16F10 cells. The new compound showed inhibitory effect on the Tyrosinase and TRP-1 gene transcription but not on the TRP-2 gene. These results suggest that the new compound of L. erythrocarpa could be used as a functional biomaterial in developing skin whitening agent.
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Lindera erythrocarpa Makino extract reduces obesity induced by high-fat diet in rats
안미정,Wonjun Yang,Sohi Kang,Min-Chul Kang,Ryeo Kyeong Ko,Gi-Ok Kim,신태균 경희대학교 융합한의과학연구소 2010 Oriental Pharmacy and Experimental Medicine Vol.10 No.4
Lindera erythrocarpa Makino (LE) is widely distributed on Jeju Island, where it has been used for various traditional therapies. Effects of a crude extract of LE were examined in rats with obesity induced by a high-fat diet (HFD). Anti-obesity effects were followed in rats receiving orally administered vehicle, 100mg/kg extract, or 250 mg/kg LE extract, for 56 days. LE extract (250mg/kg) suppressed increases in body weight and epididymal fat, with amelioration of fatty changes in the liver. Additionally, serum levels of alanine aminotransferase, aspartate aminotransferase, and total cholesterol were significantly decreased compared with those of vehicle-treated groups (p <0.05). These results suggest that oral administration of LE extract reduced rat obesity induced by HFD, possibly through the reduction of fat accumulation.
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Lindera erythrocarpa Makino extract reduces obesity induced by high-fat diet in rats
Ahn, Mee-Jung,Yang, Won-Jun,Kang, So-Hi,Kang, Min-Chul,Ko, Ryeo-Kyeong,Kim, Gi-Ok,Shin, Tae-Kyun Kyung Hee Oriental Medicine Research Center 2010 Oriental pharmacy and experimental medicine Vol.10 No.4
Lindera erythrocarpa Makino (LE) is widely distributed on Jeju Island, where it has been used for various traditional therapies. Effects of a crude extract of LE were examined in rats with obesity induced by a high-fat diet (HFD). Anti-obesity effects were followed in rats receiving orally administered vehicle, 100mg/kg extract, or 250 mg/kg LE extract, for 56 days. LE extract (250 mg/kg) suppressed increases in body weight and epididymal fat, with amelioration of fatty changes in the liver. Additionally, serum levels of alanine aminotransferase, aspartate aminotransferase, and total cholesterol were significantly decreased compared with those of vehicle-treated groups (p < 0.05). These results suggest that oral administration of LE extract reduced rat obesity induced by HFD, possibly through the reduction of fat accumulation.
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충남 홍성지역에서 자란 비목나무(Lindera erythrocarpa)의 열기건조스케쥴 개발
강춘원 ( Chun-won Kang ),강호양 ( Ho-yang Kang ) 한국목재공학회 2018 목재공학 Vol.46 No.1
비목나무는 줄기가 곧고 직경이 40 cm까지 자라지만 아직 미사용되고 있다. 잘 알려지지 않은 수종을 이용하려면 먼저 그 수종의 열기건조스케쥴을 찾아야 한다. 비목나무의 열기건조스케쥴을 테라자와의 오븐급속건조법으로 추정하였으며, 열기건조 실험을 통해 검증하였다. 비목나무의 평균 생재함수율과 평균 생재비중은 각각 72.3%과 0.53이다. 테라자와의 오븐급속건조법을 사용하여 얻은 25 mm 두께 비목나무의 가장 안전한 건조조건은 초기건조온도 50℃, 초기건습구온도차 4℃, 말기건조온도 75℃이다. 이러한 조건에 맞는 미임산물연구소 스케쥴은 T5-D4이다. 추정 열기건조스케쥴 T5-D4와 새로운 개량 열기건조스케쥴 T8-C5로 25 mm 판재를 건조한 결과, 모두 불가피하게 발생한 수심재터짐 이외에는 내부할렬과 틀어짐이 전혀 발생하지 않았다. Lindera erythrocarpa is a less utilized species in Korea although that it has straight stem and it grows up to 40 cm in diameter. A proper kiln-dry schedule is required in advance to utilize an unknown species. Terazwa’s quick oven-dry method was used to find it and which was confirmed by drying 25 mm thick boards in a kiln. The average green moisture content and the average green specific gravity of Lindera erythrocarpa are 72.3% and 0.53, respectively. Prospective kiln-drying conditions obtained by Terazwa’s quick oven-dry method are a initial dry-bulb temperature of 50℃, a initial wet-bulb depression of 4℃ and a final dry-bulb temperature of 75℃, which are in a good agreement with USDA FPL kiln-dry schedule of T5-D4. 25 mm thick boards dried in a kiln with T5-D4 kiln-dry schedule did not have any severe drying defects such as honycombing and warping. A severer kiln-dry schedule of T8-C5 was developed and applied to another kiln-drying run to confirm it.
ScienceON
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