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Bao-Xiang Zhang,Gang Ding,Jun-Cheng Lyu,Hai-Bo Liu,Dian-Cai Zhang,Dian-Cai Zhang,Xing-Jie Bi,Zhi-Wu Duan 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.1
Purpose: Cutaneous lymphocyte-associated antigen (CLA)-expressing CD8+T cells have been known to play an important role in the pathogenesis of atopic dermatitis(AD). However, the mechanisms underlying the loss of self-tolerance remainunclear. Regulatory T cells (Tregs) play a key role in the development of homeostasisin the immune system. We, therefore, hypothesized that a reduced ability of Tregs to inhibit autologous CD8+CLA+T cells might be underlying mechanism in AD. Materials and Methods: CD8+CLA+T cells and Tregs were obtained from the peripheral blood of AD patients and control volunteers. The frequenciesof CD8+CLA+T cells were evaluated. The proliferative responses of CD8+CLA+T cells were assessed by flow cytometry, and the levels of transforming growth factor-β1 (TGF-β1) and interleukin-10 (IL-10) in culture supernatants were detected by enzyme-linked immunosorbent assay. Results: Our results revealed higher frequency and increased expression of perforin and granzyme-B in peripheralCD8+CLA+T cells in AD, and lower inhibitory ability of Tregs on proliferation of CD8+CLA+T cells in AD. Meanwhile, the levels of TGF-β1 produced by Tregs were significantly lower in AD, and anti-TGF-β1 abolished such suppression. Conclusion: The attenuated inhibitory ability of Tregs on hyper-activated autologousCD8+CLA+T cells, mediated by TGF-β1, plays an important role in the pathogenesis of AD.
건선에서의 피부 림프구 관련 항원 ( Cutaneous Lymphocyte-Associated Antigen ) 의 발현
장경애(Kyoung Ae Jang),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.10
Background:Arbutin is a glycosylated hydroquinone found at high concentration in certain plants capable of surviving extreme and sustained dehydration. It has been suggested as an inhibitory compound of melanogenesis. Objective:The purpose of this study was to investigate the effect of arbutin on melanogenesis in cultured human melanocytes and to evaluate the effectiveness of arbutin in patients with melasma. Methods:I. In vitro study:we examine the cell number, SRB assay, tyrosinase activity, and melanin contents of cultured human melanocytes in control(absence of arbutin) and experimental groups (presence of 10-5 M, 10-4 M, and 10-3 M arbutin). II. In vivo study:6 patients with melasma applied a 3 % arbutin solution twice daily for 8 weeks. Clinical response to treatment was evaluated by patients' subjective assessment and MASI(Melasma Area and Severity Index) score after 8 weeks of treatment. Results:I. In vitro study 1. The number of melanocytes was decreased in groups treated with 10-5 M, 10-4 M, 10-3 M arbutin for 2 days and 10-4 M, 10-3 M arbutin for 7 days. 2. On SRB assay, the proliferation of melanocytes was decreased in groups treated with 10-5 M, 10-4 M, 10-3 M arbutin for 2 days and for 7 days. 3. Tyrosinase activity was decreased in groups treated with 10-4 M, 10-3 M arbutin for 2 days and 10-5 M, 10-4 M, 10-3 M arbutin for 7 days. 4. The melanin contents were decreased in group treated with 10-3 M arbutin for 7 days. II. In vivo study 1. On patients'subjective assessment, one showed moderate improvement, one showed mild improvement, and the other four showed no change. 2. On MASI score, there was less than 10% improvement in all 6 patients. 3. Side effects were not found in all 6 patients.Conclusion:Although arbutin showed an inhibitory effect on cell proliferation, tyrosinase activity, and melanin synthesis in cultured human melanocytes, there was no significant effect of depigmentation in the patients with melasma. (Korean J Dermatol 2000;38(10):1303~1308)
중증 아토피피부염 환아에서 Cyclosporine 치료 후 T세포의 변화
이소연 ( Lee So Yeon ),박진호 ( Park Jin Ho ),심정연 ( Sim Jeong Yeon ),김자형 ( Kim Ja Hyeong ),김봉성 ( Kim Bong Seong ),서지혜 ( Seo Ji Hye ),장성옥 ( Jang Seong Og ),홍수종 ( Hong Su Jong ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2004 소아알레르기 및 호흡기학회지 Vol.14 No.1
목적: 중증의 아토피피부염 치료에 비교적 안전하게 쓰이는 cyclosporine은 활성화된 T림프구와 T림프구에서 생성하는 사이토카인을 조절하는데 아토피피부염에서의 정확한 기전은 밝혀진 바가 적다. 표피 림프구 항원 (cutaneous lymphocyte antigen, CLA)을 발현하는 skin-homing 기억 T림프구는 아토피피부염의 병인에 있어서 중요한 역할을 하는데, cyclosporine 치료 전후로 이러한 CLA+T 림프구의 변화를 보고자 Background: Skin-homing T cells expressing cutaneous lymphocyte antigen (CLA) are known to be important in the pathogenesis of atopic dermatitis (AD). Cyclosporine is known as an effective treatment for severe atopic dermatitis, which controls the cytokin