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Impact of Treatment Type on Overall Survival in Elderly Brazilian Women with Breast Cancer
Bello, Marcelo Adeodato,de Menezes, Raquel Ferreira,de Sousa Silva, Brunna,da Silva, Rafael de Carvalho,Cavalcanti, Rousiane Silva,da Costa Moraes, Thayane de Fatima,Tonellotto, Fabiana,de Aguiar, Suz Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.10
Objective: To analyze the survival of elderly patients with breast cancer according to the type of treatment used. Methods: A cohort study of women aged 80 or over with breast cancer registered with the Brazilian National Cancer Institute (Instituto Nacional do $C{\hat{a}}ncer$ - INCA) between 2008 and 2009 was conducted. Prognosis was analyzed according to the cancer treatment performed: surgery, radiotherapy, or hormone therapy. Analysis of the overall 5-year survival rate was performed using the Kaplan - Meier method, and comparisons of curves were undertaken using the log-rank test. For multiple regression analysis, Cox regression was used, adjusting for age and clinical stage, considering values of p < 0.05 as significant. Data were all analyzed using the statistical package SPSS version 20. Results: 70 women with a mean age of $84.0{\pm}3.7years$ at diagnosis participated in the study. The median follow-up time was 37.1 months (range 0.5-75.5), and 31 deaths (44.3%) occurred during this time. The median survival time was 51.2 months (95% CI, 44.9-57.4), higher in those who underwent surgery (p = 0.012) and those who had hormone therapy (p=0.001). Treatment with surgery reduced the risk of death by 61.7% (HR 0.3; 95% CI, 0.1-0.6; p = 0.001) when adjusted for clinical stage and age at diagnosis. However, there was no significant benefit from radiotherapy (HR 1.2; 95% CI, 0.5-2.5; p = 0.694). Conclusion: Treatment with surgery and hormone therapy increased the survival of our Brazilian patients with breast cancer aged 80 or over.
de Aguiar Guilherme Carletti,Batalha Daniel Carreira,Fajardo Humberto Vieira,Filho José Balena Gabriel,Bruziquesi Carlos Giovanni Oliveira,de Oliveira Luiz Carlos Alves,Gonçalves Mateus Aquino,Ramalho 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.10
In this work, the application of a new, synthesized niobium-based catalyst, called S4 (niobium oxyhydroxide), in the liquid-phase oxidation of methyl-phenyl sulfide (thioanisole) using hydrogen peroxide as oxidant was proposed. The synthetic method employed provided a material with low crystallinity and high specific surface area and acidity. A commercial material, called HY-340 (hydrated niobium oxide), was also employed as heterogeneous catalyst for comparative purposes. The results showed that the synthesized S4 material is an outstanding catalyst, being able to completely convert the substrate (thioanisole) that achieves almost 90% of selectivity for methyl phenyl sulfone formation, under mild reaction conditions. According to the theoretical and experimental combined results, the superior performance of S4 catalyst is related to the better interaction of H2O2 and thioanisole molecules with S4 surface, compared to HY-340, pointing to the greater ability of this catalyst to form reactive oxygen species in contact with hydrogen peroxide, due to its higher content of free hydroxyl groups present on its surface.
Cristiane Aguiar da Costa,Dayane Teixeira Ognibene,Viviane Silva Cristino Cordeiro,Graziele Freitas de Bem,Izabelle Barcellos Santos,Ricardo Andrade Soares,Letı´cia L. de Melo Cunha,Lenize C. R.M. Car 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.10
Previously, we have demonstrated that the seeds of Euterpe oleracia Mart. (açaí) are rich in polyphenols with antihypertensive and antioxidant properties. This study evaluated the renal protective effects of the hydroalcoholic extract obtained from the seeds of açaí (ASE) fruits in two-kidney, one-clip (2K1C) renovascular hypertension. Young male Wistar rats were used to obtain 2K1C and sham groups. Animals received ASE (200 mg/(kg·day) in drinking water) or vehicle for 40 days. We evaluated serum and urinary parameters, renal structural changes, and oxidative status. The increase in systolic blood pressure of the 2K1C group was accompanied by a decrease in left kidney volume and number of glomeruli, as well as an increase in glomerular volume and collagen deposition. ASE prevented the alterations of these parameters, except the reduced kidney volume. Serum levels of urea and creatinine and urinary protein excretion were increased in the 2K1C group and treatment with ASE improved all these functional parameters. The increased oxidative damage in the 2K1C group, assessed by lipid and protein oxidation, was prevented by ASE. The nitrite content and both expression and activity of antioxidant enzymes (superoxide dismutase-1, catalase, and glutathione peroxidase) were lower in the 2K1C group and restored by ASE. ASE substantially reduced renal injury and prevented renal dysfunction in 2K1C rats probably through its antihypertensive and antioxidant effects, providing a natural resource for treatment and prevention of renovascular hypertension-related abnormalities.
Evaluation and Redesign of the Inverted Decoupler: Open and Closedloop Approaches
Anna Paula V. de A. Aguiar,George Acioli Júnior,Péricles R. Barros 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.6
The inverted decoupler is usually designed from estimated process models. These models are usually of reduced order, so that effective decoupling is not always achieved. The redesign of decouplers is a subject that received little attention in literature. In this paper, the methodology for decoupler evaluation and redesign in openloop is reviewed. In addition, a new closed-loop evaluation and redesign methodology is presented. This is the main contribution of this paper. The initial decoupler is evaluated by applying a relay-based excitation signal to the decoupled process. If necessary, the decoupler is redesigned to obtain an effective decoupling at some frequencies of interest. Simulation results is used to illustrate the methodology.
Lucas Glaucio da Silva,Waleska Rayanne Sizinia da Silva Monteiro,Tiago Medeiros de Aguiar Moreira,Maria Aparecida Esteves Rabelo,Emílio Augusto Campos Pereira de Assis,de Souza Gustavo Torres 한국현미경학회 2021 Applied microscopy Vol.51 No.1
Histopathology is a well-established standard diagnosis employed for the majority of malignancies, including breast cancer. Nevertheless, despite training and standardization, it is considered operator-dependent and errors are still a concern. Fractal dimension analysis is a computational image processing technique that allows assessing the degree of complexity in patterns. We aimed here at providing a robust and easily attainable method for introducing computer-assisted techniques to histopathology laboratories. Slides from two databases were used: A) Breast Cancer Histopathological; and B) Grand Challenge on Breast Cancer Histology. Set A contained 2480 images from 24 patients with benign alterations, and 5429 images from 58 patients with breast cancer. Set B comprised 100 images of each type: normal tissue, benign alterations, in situ carcinoma, and invasive carcinoma. All images were analyzed with the FracLac algorithm in the ImageJ computational environment to yield the box count fractal dimension (Db) results. Images on set A on 40x magnification were statistically different ( p = 0.0003), whereas images on 400x did not present differences in their means. On set B, the mean Db values presented promissing statistical differences when comparing. Normal and/or benign images to in situ and/or invasive carcinoma (all p < 0.0001). Interestingly, there was no difference when comparing normal tissue to benign alterations. These data corroborate with previous work in which fractal analysis allowed differentiating malignancies. Computer-aided diagnosis algorithms may beneficiate from using Db data; specific Db cut-off values may yield ~ 99% specificity in diagnosing breast cancer. Furthermore, the fact that it allows assessing tissue complexity, this tool may be used to understand the progression of the histological alterations in cancer.
Marta Maria Oliveira dos Santos,Luiz Henrique Sales de Menezes,Eliézer Luz do Espirito Santo,Marise Silva de Carvalho,Márcia Soares Gonçalves,Iasnaia Maria de Carvalho Tavares,Adriano Aguiar Mendes,Hé 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.5
This study aims at the synthesis of hexyl butyrate by Candida rugosa lipase (CRL) immobilized on Diaion HP 20. The lipase load used was 28.7 ± 2.1 mg/g (mg of lipase/g of support), whose hydrolytic activity was 132.0 ± 2.5 U/g. To obtain the maximum production of hexyl butyrate, the Box-Behnken design statistical planning was used, having as independent variables; biocatalyst concentration, temperature and acid:alcohol molar ratio and ester conversion as a dependent variable at 60, 180 and 480 min. For 60 min, 90.8% conversion was obtained at 47.25 ºC, 1:1.4 molar ratio and 17.65% of biocatalyst; 180 min, 94.5% conversion at 59.5 ºC, 1:2 molar ratio and 15.8% biocatalyst; 480 min, 95.01% conversion at 47.0 ºC, 1:2 molar ratio and 16.9% biocatalyst. CRL-Diaion HP 20 retained 60% of its initial activity after ten cycles of reactions showing potential for industrial use. The ester produced was identified by gas chromatography analyses.
Effect of ultrasonic tip designs on intraradicular post removal
Aguiar, Anny Carine Barros,de Meireles, Daniely Amorim,Marques, Andre Augusto Franco,Sponchiado, Emilio Carlos Junior,Garrido, Angela Delfina Bitencourt,Garcia, Lucas Da Fonseca Roberti The Korean Academy of Conservative Dentistry 2014 Restorative Dentistry & Endodontics Vol.39 No.4
Objectives: To evaluate the effect of different ultrasonic tip designs on intraradicular post removal. Materials and Methods: The crowns of forty human canine teeth were removed, and after biomechanical preparation and filling, the roots were embedded in acrylic resin blocks. The post spaces were made, and root canal molding was performed with self-cured acrylic resin. After casting (Cu-Al), the posts were cemented with zinc phosphate cement. The specimens were randomly separated into 4 groups (n = 10), as follows: G1 - no ultrasonic vibration (control); G2 - ultrasonic vibration using an elongated cylindrical-shaped and active rounded tip; G3 - ultrasonic vibration with a flattened convex and linear active tip; G4 - ultrasonic vibration with active semicircular tapered tip. Ultrasonic vibration was applied for 15 seconds on each post surface and tensile test was performed in a Universal Testing Machine (Instron 4444 - 1 mm/min). Results: G4 presented the highest mean values, however, with no statistically significant difference in comparison to G3 (p > 0.05). G2 presented the lowest mean values with statistically significant difference to G3 and G4 (p < 0.05). Conclusions: Ultrasonic vibration with elongated cylindrical-shaped and active rounded tip was most effective in reducing force required for intraradicular post removal.
Effect of ultrasonic tip designs on intraradicular post removal
Anny Carine Barros Aguiar,Daniely Amorim de Meireles,André Augusto Franco Marques,Emílio Carlos Sponchiado Júnior,Angela Delfina Bitencourt Garrido,Lucas da Fonseca Roberti Garcia 대한치과보존학회 2014 Restorative Dentistry & Endodontics Vol.39 No.4
Objectives: To evaluate the effect of different ultrasonic tip designs on intraradicular post removal. Materials and Methods: The crowns of forty human canine teeth were removed, and after biomechanical preparation and filling, the roots were embedded in acrylic resin blocks. The post spaces were made, and root canal molding was performed with self-cured acrylic resin. After casting (Cu-Al), the posts were cemented with zinc phosphate cement. The specimens were randomly separated into 4 groups (n = 10), as follows: G1 - no ultrasonic vibration (control); G2 - ultrasonic vibration using an elongated cylindrical-shaped and active rounded tip; G3 - ultrasonic vibration with a flattened convex and linear active tip; G4 - ultrasonic vibration with active semicircular tapered tip. Ultrasonic vibration was applied for 15 seconds on each post surface and tensile test was performed in a Universal Testing Machine (Instron 4444 - 1 mm/min). Results: G4 presented the highest mean values, however, with no statistically significant difference in comparison to G3 (p > 0.05). G2 presented the lowest mean values with statistically significant difference to G3 and G4 (p < 0.05). Conclusions: Ultrasonic vibration with elongated cylindrical-shaped and active rounded tip was most effective in reducing force required for intraradicular post removal.
Paiva Aline Lariessy Campos,Aguiar Guilherme Brasileiro de,Flores Juan Antonio Castro,Veiga José Carlos Esteves 대한뇌혈관외과학회 2021 Journal of Cerebrovascular and Endovascular Neuros Vol.23 No.3
Blood Blister-like aneurysms are intracranial non-saccular aneurysms with higher rupture risk due to its fragile wall. Diagnosis is performed in the acute phase of a subarachnoid hemorrhage. There are several treatment options based on reconstructive or deconstructive techniques. This paper aims to discuss the limitations of microsurgery clipping for a ruptured blister aneurysm. We report on a case of a female patient presented with a Fisher III subarachnoid hemorrhage. Cerebral angiography revealed an internal carotid artery blister aneurysm. Initially microsurgery clipping was successfully performed. However, after a few days the patient presented new subarachnoid hemorrhage. The new cerebral angiography showed growth of the previously clipped aneurysm, with displacement of the clip from the position adjacent to the artery. High-flow bypass was performed obtaining definitive treatment. This is a definitive approach for blister aneurysms. If microsurgery clipping is chosen, a strict follow-up is required due to the dynamic nature of this lesion and the chance of re-bleeding even after successfully clipping.