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- 저자 : Zoltan Papp (검색결과 3 건)
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Nandor Gabor Than,Roberto Romero,Andrea Balogh,Eva Karpati,Salvatore Andrea Mastrolia,Orna Staretz-Chacham,Sinuhe Hahn,Offer Erez,Zoltan Papp,김종재 대한병리학회 2015 Journal of Pathology and Translational Medicine Vol.49 No.3
Galectins are an evolutionarily ancient and widely expressed family of lectins that have unique glycan-binding characteristics. They are pleiotropic regulators of key biological processes, such as cell growth, proliferation, differentiation, apoptosis, signal transduction, and pre-mRNA splicing, as well as homo- and heterotypic cell-cell and cell-extracellular matrix interactions. Galectins are also pivotal in immune responses since they regulate host-pathogen interactions, innate and adaptive immune responses, acute and chronic inflammation, and immune tolerance. Some galectins are also central to the regulation of angiogenesis, cell migration and invasion. Expression and functional data provide convincing evidence that, due to these functions, galectins play key roles in shared and unique pathways of normal embryonic and placental development as well as oncodevelopmental processes in tumorigenesis. Therefore, galectins may sometimes act as double-edged swords since they have beneficial but also harmful effects for the organism. Recent advances facilitate the use of galectins as biomarkers in obstetrical syndromes and in various malignancies, and their therapeutic applications are also under investigation. This review provides a general overview of galectins and a focused review of this lectin subfamily in the context of inflammation, infection and tumors of the female reproductive tract as well as in normal pregnancies and those complicated by the great obstetrical syndromes.
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Rudolf Gesztelyi,Zita Wachal,Bela Juhasz,Mariann Bombicz,Evelin Csepanyi,Krisztian Pak,Judit Zsuga,Csaba Papp,Zoltan Galajda,Klara Branzaniuc,Robert Porszasz,Andras Jozsef Szentmiklosi,Arpad Tosaki,Zs 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.3
A1 adenosine receptors (A1 receptors) arewidely expressed in mammalian tissues; therefore attainingproper tissue selectivity is a cornerstone of drug development. The fact that partial agonists chiefly act on tissueswith great receptor reserve can be exploited to achieve anappropriate degree of tissue selectivity. To the best of ourknowledge, the A1 receptor reserve has not been yetquantified for the atrial contractility. A1 receptor reservewas determined for the direct negative inotropic effect ofthree A1 receptor full agonists (NECA, CPA and CHA) inisolated, paced guinea pig left atria, with the use of FSCPX, an irreversible A1 receptor antagonist. FSCPXcaused an apparently pure dextral displacement of theconcentration–response curves of A1 receptor agonists. Accordingly, the atrial A1 receptor function converging toinotropy showed a considerably great, approximately80–92 % of receptor reserve for a near maximal (about91–96 %) effect, which is greater than historical atrial A1receptor reserve data for any effects other than inotropy. Consequently, the guinea pig atrial contractility is verysensitive to A1 receptor stimulation. Thus, it is worthwhileconsidering that even partial A1 receptor agonists, given inany indication, might decrease the atrial contractile force,as an undesirable side effect, in humans.
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Characteristic Changes in Decidual Gene Expression Signature in Spontaneous Term Parturition
Haidy El-Azzamy,Nandor Gabor Than,Andrea Balogh,Roberto Romero,Yi Xu,Christopher LaJeunesse,Olesya Plazyo,Zhonghui Xu,Theodore G. Price,Zhong Dong,Adi L. Tarca,Zoltan Papp,Sonia S. Hassan,Tinnakorn Ch 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.3
Background: The decidua has been implicated in the “terminal pathway” of human term parturition, which is characterized by the activation of pro-inflammatory pathways in gestational tissues. However, the transcriptomic changes in the decidua leading to terminal pathway activation have not been systematically explored. This study aimed to compare the decidual expression of developmental signaling and inflammation-related genes before and after spontaneous term labor in order to reveal their involvement in this process. Methods: Chorioamniotic membranes were obtained from normal pregnant women who delivered at term with spontaneous labor (TIL, n = 14) or without labor (TNL, n = 15). Decidual cells were isolated from snap-frozen chorioamniotic membranes with laser microdissection. The expression of 46 genes involved in decidual development, sex steroid and prostaglandin signaling, as well as pro- and anti-inflammatory pathways, was analyzed using high-throughput quantitative real-time polymerase chain reaction (qRT-PCR). Chorioamniotic membrane sections were immunostained and then semi-quantified for five proteins, and immunoassays for three chemokines were performed on maternal plasma samples. Results: The genes with the highest expression in the decidua at term gestation included insulin-like growth factor-binding protein 1 (IGFBP1), galectin-1 (LGALS1), and progestogen-associated endometrial protein (PAEP); the expression of estrogen receptor 1 (ESR1), homeobox A11 (HOXA11), interleukin 1β (IL1B), IL8, progesterone receptor membrane component 2 (PGRMC2), and prostaglandin E synthase (PTGES) was higher in TIL than in TNL cases; the expression of chemokine C-C motif ligand 2 (CCL2), CCL5, LGALS1, LGALS3, and PAEP was lower in TIL than in TNL cases; immunostaining confirmed qRT-PCR data for IL-8, CCL2, galectin-1, galectin-3, and PAEP; and no correlations between the decidual gene expression and the maternal plasma protein concentrations of CCL2, CCL5, and IL-8 were found. Conclusions: Our data suggests that with the initiation of parturition, the decidual expression of anti-inflammatory mediators decreases, while the expression of pro-inflammatory mediators and steroid receptors increases. This shift may affect downstream signaling pathways that can lead to parturition.
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