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Carbon dioxide reforming of methane for syngas production over Co–MgO mixed oxide nanocatalysts
Fateme Mirzaei,Mehran Rezaei,Fereshteh Meshkani,Zohreh Fattah 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1
Carbon dioxide reforming of methane (CH4 + CO2$2CO + 2H2) was studied over nanostructure Co–MgO mixed oxide catalysts with different cobalt contents. The catalysts were prepared by coprecipitationmethod and characterized using XRD, BET, TEM, TPR, SEM and TPO techniques. The BETanalysis showed a high specific surface area and mesoporous structure (pore sizes < 15 nm) and the TEManalysis indicated a nanostructure with crystallite sizes smaller than 10 nm for the prepared catalysts. The obtained results revealed that the catalyst with cobalt content of 10 wt.% had the highest activity andstability in dry reforming reaction.
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Evaluation of the Effect of Pentoxifylline on Cisplatin-Induced Testicular Toxicity in Rats
Ali Reza Fallahzadeh,Zohreh Rezaei,Hamid Reza Rahimi,Mehrazd Jafari Barmak,Hossein Sadeghi,Sadrollah Mehrabi,Seyed Mohammadreza Rabani,Iraj Ragerdi Kashani,Vahid Barati,Reza Mahmoudi 한국독성학회 2017 Toxicological Research Vol.33 No.3
Chemotherapy is associated with male infertility. Cisplatin (cis-diamminedichloro-platinum (II) (CDDP) as a chemotherapy medication used to treat a number of cancers has been reported to most likely induce testicular toxicity. Administration of antioxidants, such as pentoxifylline (PTX) may reduce some Adverse Drug Reactions (ADRs) of CDDP. Therefore, this study investigated the potentially protective effects of PTX on CDDP-induced testicular toxicity in adult male rats. For this purpose, 42 male rats were randomly divided into 7 groups. The rats were orally pretreated with PTX at the 3 doses of 75, 150, and 300 mg/kg once a day for 14 successive days. On the 14<SUP>th</SUP> day of the study, they were intraperitoneally (IP) administered with a single dose of CDDP (7 mg/kg). Finally, the sperm/testis parameters, serum levels of reproductive hormones, including testosterone, Luteinizing Hormone (LH), and Follicle Stimulating Hormone (FSH) as the pivotal endocrine factors controlling testicular functions, and histopathological changes of testis tissue were examined. Pretreatment with the two doses of 75 and 150 mg/kg PTX indicated significant increases in the sperm count and motility induced by CDDP administration. The right and significantly left testis weights were decreased following the treatment with 300 mg/kg of PTX plus CDDP. However, 75 mg/kg of PTX plus CDDP showed the best near-to-normal histopathological features. The results demonstrated that PTX alone enhanced some parameters, such as the sperm count, while reducing other parameters, including sperm fast motility and germ layer thickness. Furthermore, despite testosterone or LH levels, the mean serum FSH level was significantly augmented by the doses of 75 and 150 mg/kg. It was concluded that PTX administration cannot reduce CDDP-induced testicular toxicity even at high doses (e.g., 300 mg/kg), while it seemed to partially intensify CDDP toxicity effects at a dose of 75 mg/kg. Thus, further research is required in this regard.
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Evaluation of the Effect of Pentoxifylline on Cisplatin-Induced Testicular Toxicity in Rats
Fallahzadeh, Ali Reza,Rezaei, Zohreh,Rahimi, Hamid Reza,Barmak, Mehrazd Jafari,Sadeghi, Hossein,Mehrabi, Sadrollah,Rabani, Seyed Mohammadreza,Kashani, Iraj Ragerdi,Barati, Vahid,Mahmoudi, Reza Korean Society of ToxicologyKorea Environmental Mu 2017 Toxicological Research Vol.33 No.3
Chemotherapy is associated with male infertility. Cisplatin (cis-diamminedichloro-platinum (II) (CDDP) as a chemotherapy medication used to treat a number of cancers has been reported to most likely induce testicular toxicity. Administration of antioxidants, such as pentoxifylline (PTX) may reduce some Adverse Drug Reactions (ADRs) of CDDP. Therefore, this study investigated the potentially protective effects of PTX on CDDP-induced testicular toxicity in adult male rats. For this purpose, 42 male rats were randomly divided into 7 groups. The rats were orally pretreated with PTX at the 3 doses of 75, 150, and 300 mg/kg once a day for 14 successive days. On the $14^{th}$ day of the study, they were intraperitoneally (IP) administered with a single dose of CDDP (7 mg/kg). Finally, the sperm/testis parameters, serum levels of reproductive hormones, including testosterone, Luteinizing Hormone (LH), and Follicle Stimulating Hormone (FSH) as the pivotal endocrine factors controlling testicular functions, and histopathological changes of testis tissue were examined. Pretreatment with the two doses of 75 and 150 mg/kg PTX indicated significant increases in the sperm count and motility induced by CDDP administration. The right and significantly left testis weights were decreased following the treatment with 300 mg/kg of PTX plus CDDP. However, 75 mg/kg of PTX plus CDDP showed the best near-to-normal histopathological features. The results demonstrated that PTX alone enhanced some parameters, such as the sperm count, while reducing other parameters, including sperm fast motility and germ layer thickness. Furthermore, despite testosterone or LH levels, the mean serum FSH level was significantly augmented by the doses of 75 and 150 mg/kg. It was concluded that PTX administration cannot reduce CDDP-induced testicular toxicity even at high doses (e.g., 300 mg/kg), while it seemed to partially intensify CDDP toxicity effects at a dose of 75 mg/kg. Thus, further research is required in this regard.
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Salajegheh Faranak,Rukerd Mohammad Rezaei Zadeh,Nakhaie Mohsen,Ghoreshi Zohreh-Al-Sadat,Charostad Javad,Arefinia Nasir 대한백신학회 2024 Clinical and Experimental Vaccine Research Vol.13 No.2
The emergence of coronavirus disease 2019 (COVID-19) vaccines has been a remarkable advancement. However, the efficacy, immunogenicity, and safety of these vaccines in individuals with liver cirrhosis require careful evaluation due to their compromised immune status and potential interactions with underlying liver disease. The present study aimed to evaluate the safety and efficacy of COVID-19 vaccines in liver cirrhosis patients. In the present study, we searched international databases, including Google Scholar, PubMed, Scopus, Embase, and Web of Science. The search strategy was carried out by using keywords and MeSH (Medical Subject Headings) terms. STATA ver. 15.0 (Stata Corp., USA) was used to analyze the data statistically. The analysis was performed using the randomeffects model. We also used the chi-square test and I2 index to calculate heterogeneity among studies. For evaluating publication bias, Begg’s funnel plots and Egger’s tests were used. A total of 4,831 liver cirrhosis patients with COVID-19 were examined from 11 studies. The rate of hospitalization in the patients with liver cirrhosis was 17.6% (95% confidence interval [CI], 9%–44%). The rate of fever in the patients with liver cirrhosis was 4.5% (95% CI, 0.9%–8.1%). The rate of positive neutralizing antibodies in the patients with liver cirrhosis was 82.5% (95% CI, 69.8%–95.1%). Also, the rates of seroconversion after the second vaccination in patients with liver cirrhosis and the control group were 96.6% (95% CI, 92.0%–99.0%), and 99.7% (95% CI, 99.0%–100.0%), respectively. COVID-19 vaccines have demonstrated promising efficacy, immunogenicity, and safety profiles in individuals with liver cirrhosis, providing crucial protection against COVID-19-related complications.
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