The Mammalian Ste20-like Kinase 2 (Mst2) Modulates Stress-induced Cardiac Hypertrophy

Zi, Min,Maqsood, Arfa,Prehar, Sukhpal,Mohamed, Tamer M. A.,Abou-Leisa, Riham,Robertson, Abigail,Cartwright, Elizabeth J.,Ray, Simon G.,Oh, Sangphil,Lim, Dae-Sik,Neyses, Ludwig,Oceandy, Delvac American Society for Biochemistry and Molecular Bi 2014 The Journal of biological chemistry Vol.289 No.35

<P>The Hippo signaling pathway has recently moved to center stage in cardiac research because of its key role in cardiomyocyte proliferation and regeneration of the embryonic and newborn heart. However, its role in the adult heart is incompletely understood. We investigate here the role of mammalian Ste20-like kinase 2 (Mst2), one of the central regulators of this pathway. <I>Mst2</I><SUP>−/−</SUP> mice showed no alteration in cardiomyocyte proliferation. However, <I>Mst2</I><SUP>−/−</SUP> mice exhibited a significant reduction of hypertrophy and fibrosis in response to pressure overload. Consistently, overexpression of <I>MST2</I> in neonatal rat cardiomyocytes significantly enhanced phenylephrine-induced cellular hypertrophy. Mechanistically, Mst2 positively modulated the prohypertrophic Raf1-ERK1/2 pathway. However, activation of the downstream effectors of the Hippo pathway (Yes-associated protein) was not affected by Mst2 ablation. An initial genetic study in mitral valve prolapse patients revealed an association between a polymorphism in the human <I>MST2</I> gene and adverse cardiac remodeling. These results reveal a novel role of Mst2 in stress-dependent cardiac hypertrophy and remodeling in the adult mouse and likely human heart.</P>

Surface nanostructuring of CuIn_1−<i>x</i>Ga_<i>x</i>Se₂ films using argon plasma treatment

Zimin, S P,Gorlachev, E S,Mokrov, D A,Amirov, I I,Naumov, V V,Gremenok, V F,Juskenas, R,Skapas, M,Kim, W Y,Bente, K,Chung, Y-D IOP 2017 Semiconductor science and technology Vol.32 No.7

<P>In this work we report a phenomenon of the self-formation of nanostructure arrays during low-energy inductively coupled argon plasma treatment of the surface of copper indium gallium diselenide films grown by different methods on glass substrates. Selenization, pulsed laser deposition and multistage co-evaporation technological methods were used for the growth of polycrystalline CuIn<SUB>1−<I>x</I> </SUB>Ga<SUB> <I>x</I> </SUB>Se<SUB>2</SUB> (0.04?≤?<I>x</I>?≤?0.45) films. The plasma treatment of the surface of the films grown by all three methods resulted in the plasma-assisted self-formation of arrays of uniform cylindrical or conical nanostructures with the surface density of (0.8–1.8)?×?10<SUP>11</SUP> cm<SUP>−2</SUP>. Using scanning electron microscopy, transmission electron microscopy and atomic force microscopy, we describe the morphological parameters and chemical composition of the fabricated nanostructures and discuss possible physical mechanisms of the observed plasma-assisted nanostructuring.</P>

Physical Peculiarities of Charge Carriers Transport in Porous Silicon Structures

Zimin, S. P.,Kuznetsov, V. S.,Prokaznikov, A. V. 대한전자공학회 1993 ICVC : International Conference on VLSI and CAD Vol.3 No.1

In this paper electrophysical and optical properties of porous silicon films are theoretically and experimentally investigated. The hypotheses put forward about superlattice formation in order to explain the photoluminescene peculiarities. Electrophysical properties of Al - porous silicon - mono-silicon - Al structures are experimentally investigated. It was stated that such a structure is equivalent tv two diodes that are switched towards each other The temperature dependence of porous silicon resistance is studied.

KEY TECHNOLOGIES OF FLOOD DEFENSE IN URBAN AREAS

YUAN ZIMIN,HU CHANGWEI,WANG YANYAN,ZHANG HONGPIN,WAN HONGTAO 한국수자원학회 2005 한국수자원학회 학술대회 Vol.2005 No.1

U²Net-based Single-pixel Imaging Salient Object Detection

Leihong Zhang,Zimin Shen,Weihong Lin(강사),Dawei Zhang 한국광학회 2022 Current Optics and Photonics Vol.6 No.5

At certain wavelengths, single-pixel imaging is considered to be a solution that can achieve high quality imaging and also reduce costs. However, achieving imaging of complex scenes is an overhead-intensive process for single-pixel imaging systems, so low efficiency and high consumption are the biggest obstacles to their practical application. Improving efficiency to reduce overhead is the solution to this problem. Salient object detection is usually used as a pre-processing step in computer vision tasks, mimicking human functions in complex natural scenes, to reduce overhead and improve efficiency by focusing on regions with a large amount of information. Therefore, in this paper, we explore the implementation of salient object detection based on single-pixel imaging after a single pixel, and propose a scheme to reconstruct images based on Fourier bases and use U2Net models for salient object detection.

U 2 Net-based Single-pixel Imaging Salient Object Detection

Leihong Zhang,Zimin Shen,Weihong Lin,Dawei Zhang 한국광학회 2022 Current Optics and Photonics Vol.6 No.5

At certain wavelengths, single-pixel imaging is considered to be a solution that can achieve high quality imaging and also reduce costs. However, achieving imaging of complex scenes is an overheadintensive process for single-pixel imaging systems, so low efficiency and high consumption are the biggest obstacles to their practical application. Improving efficiency to reduce overhead is the solution to this problem. Salient object detection is usually used as a pre-processing step in computer vision tasks, mimicking human functions in complex natural scenes, to reduce overhead and improve efficiency by focusing on regions with a large amount of information. Therefore, in this paper, we explore the implementation of salient object detection based on single-pixel imaging after a single pixel, and propose a scheme to reconstruct images based on Fourier bases and use U 2 Net models for salient object detection.

Research on Damage Identification of Buried Pipeline Based on Fiber Optic Vibration Signal

Weihong Lin,Wei Peng,Yong Kong,Zimin Shen,Yuzhou Du,Leihong Zhang,Dawei Zhang 한국광학회 2023 Current Optics and Photonics Vol.7 No.5

Pipelines play an important role in urban water supply and drainage, oil and gas transmission, etc. This paper presents a technique for pattern recognition of fiber optic vibration signals collected by a distributed vibration sensing (DVS) system using a deep learning residual network (ResNet). The optical fiber is laid on the pipeline, and the signal is collected by the DVS system and converted into a 64 × 64 single-channel grayscale image. The grayscale image is input into the ResNet to extract features, and finally the K-nearest-neighbors (KNN) algorithm is used to achieve the classification and recognition of pipeline damage.

Multi-Platform Next-Generation Sequencing of the Domestic Turkey (<i>Meleagris gallopavo</i>): Genome Assembly and Analysis

Dalloul, Rami A.,Long, Julie A.,Zimin, Aleksey V.,Aslam, Luqman,Beal, Kathryn,Ann Blomberg, Le,Bouffard, Pascal,Burt, David W.,Crasta, Oswald,Crooijmans, Richard P. M. A.,Cooper, Kristal,Coulombe, Rog Public Library of Science 2010 PLoS biology Vol.8 No.9

<P>A synergistic combination of two next-generation sequencing platforms with a detailed comparative BAC physical contig map provided a cost-effective assembly of the genome sequence of the domestic turkey (<I>Meleagris gallopavo</I>). Heterozygosity of the sequenced source genome allowed discovery of more than 600,000 high quality single nucleotide variants. Despite this heterozygosity, the current genome assembly (∼1.1 Gb) includes 917 Mb of sequence assigned to specific turkey chromosomes. Annotation identified nearly 16,000 genes, with 15,093 recognized as protein coding and 611 as non-coding RNA genes. Comparative analysis of the turkey, chicken, and zebra finch genomes, and comparing avian to mammalian species, supports the characteristic stability of avian genomes and identifies genes unique to the avian lineage. Clear differences are seen in number and variety of genes of the avian immune system where expansions and novel genes are less frequent than examples of gene loss. The turkey genome sequence provides resources to further understand the evolution of vertebrate genomes and genetic variation underlying economically important quantitative traits in poultry. This integrated approach may be a model for providing both gene and chromosome level assemblies of other species with agricultural, ecological, and evolutionary interest.</P><P><B>Author Summary</B></P><P>In contrast to the compact sequence of viruses and bacteria, determining the complete genome sequence of complex vertebrate genomes can be a daunting task. With the advent of “next-generation” sequencing platforms, it is now possible to rapidly sequence and assemble a vertebrate genome, especially for species for which genomic resources—genetic maps and markers—are currently available. We used a combination of two next-generation sequencing platforms, Roche 454 and Illumina GAII, and unique assembly tools to sequence the genome of the agriculturally important turkey, <I>Meleagris gallopavo</I>. Our draft assembly comprises approximately 1.1 gigabases of which 917 megabytes are assigned to specific chromosomes. Comparisons of the turkey genome sequence with those of the chicken, <I>Gallus gallus</I>, and the zebra finch, <I>Taeniopygia guttata</I>, provide insights into the evolution of the avian lineage. This genome sequence will facilitate discovery of agriculturally important genetic variants.</P>

Microbial short-chain fatty acids: a bridge between dietary fibers and poultry gut health — A review

Ali Qasim,Ma Sen,La Shaokai,Guo Zhiguo,Liu Boshuai,Gao Zimin,Farooq Umar,Wang Zhichang,Zhu Xiaoyan,Cui Yalei,Li Defeng,Shi Yinghua 아세아·태평양축산학회 2022 Animal Bioscience Vol.35 No.10

The maintenance of poultry gut health is complex depending on the intricate balance among diet, the commensal microbiota, and the mucosa, including the gut epithelium and the superimposing mucus layer. Changes in microflora composition and abundance can confer beneficial or detrimental effects on fowl. Antibiotics have devastating impacts on altering the landscape of gut microbiota, which further leads to antibiotic resistance or spread the pathogenic populations. By eliciting the landscape of gut microbiota, strategies should be made to break down the regulatory signals of pathogenic bacteria. The optional strategy of conferring dietary fibers (DFs) can be used to counterbalance the gut microbiota. DFs are the non-starch carbohydrates indigestible by host endogenous enzymes but can be fermented by symbiotic microbiota to produce shortchain fatty acids (SCFAs). This is one of the primary modes through which the gut microbiota interacts and communicate with the host. The majority of SCFAs are produced in the large intestine (particularly in the caecum), where they are taken up by the enterocytes or transported through portal vein circulation into the bloodstream. Recent shreds of evidence have elucidated that SCFAs affect the gut and modulate the tissues and organs either by activating G-protein-coupled receptors or affecting epigenetic modifications in the genome through inducing histone acetylase activities and inhibiting histone deacetylases. Thus, in this way, SCFAs vastly influence poultry health by promoting energy regulation, mucosal integrity, immune homeostasis, and immune maturation. In this review article, we will focus on DFs, which directly interact with gut microbes and lead to the production of SCFAs. Further, we will discuss the current molecular mechanisms of how SCFAs are generated, transported, and modulated the pro-and anti-inflammatory immune responses against pathogens and host physiology and gut health. The maintenance of poultry gut health is complex depending on the intricate balance among diet, the commensal microbiota, and the mucosa, including the gut epithelium and the superimposing mucus layer. Changes in microflora composition and abundance can confer beneficial or detrimental effects on fowl. Antibiotics have devastating impacts on altering the landscape of gut microbiota, which further leads to antibiotic resistance or spread the pathogenic populations. By eliciting the landscape of gut microbiota, strategies should be made to break down the regulatory signals of pathogenic bacteria. The optional strategy of conferring dietary fibers (DFs) can be used to counterbalance the gut microbiota. DFs are the non-starch carbohydrates indigestible by host endogenous enzymes but can be fermented by symbiotic microbiota to produce shortchain fatty acids (SCFAs). This is one of the primary modes through which the gut microbiota interacts and communicate with the host. The majority of SCFAs are produced in the large intestine (particularly in the caecum), where they are taken up by the enterocytes or transported through portal vein circulation into the bloodstream. Recent shreds of evidence have elucidated that SCFAs affect the gut and modulate the tissues and organs either by activating G-protein-coupled receptors or affecting epigenetic modifications in the genome through inducing histone acetylase activities and inhibiting histone deacetylases. Thus, in this way, SCFAs vastly influence poultry health by promoting energy regulation, mucosal integrity, immune homeostasis, and immune maturation. In this review article, we will focus on DFs, which directly interact with gut microbes and lead to the production of SCFAs. Further, we will discuss the current molecular mechanisms of how SCFAs are generated, transported, and modulated the pro-and anti-inflammatory immune responses against pathogens and host physiology and gut health.

Case RePort : IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma

( Victor M Zaydfudim ),( Andrew Y Wang ),( Eduard E De Lange ),( Zimin Zhao ),( Christopher A Moskaluk ),( Todd W Bauer ),( Reid B Adams ) 대한간학회 2015 Gut and Liver Vol.9 No.4

IgG4-associated cholangitis can mimic hilar cholangiocarcinoma. Previously reported patients with IgG4-associated cholangitis mimicking cholangiocarcinoma had elevated serum IgG4 levels and long-segment biliary strictures. However, in the absence of other diagnostic criteria for malignancy, IgG4-associated cholangitis should remain a consideration among patients with normal serum IgG4 and a hilar mass suspicious for cholangiocarcinoma. The presence of a hilar mass and a malignant-appearing biliary stricture in two patients with normal serum IgG4 prompted further evaluation and subsequent concomitant liver and bile duct resection and reconstruction. The diagnosis of IgG4-associated cholangitis was established during the pathologic evaluation of the resected specimens. IgG4-associated cholangitis is a known imitator of hilar cholangiocarcinoma and should be considered in the differential diagnosis even among serologically IgG4-negative patients with a hilar mass prior to operative resection. (Gut Liver 2015;9:556-560)