Risk factors and long-term prognosis of BCLC stage 0/A hepatocellular carcinoma for beyond milan recurrence after hepatectomy: A multicenter observational study

Zi-Han FENG,Ming-Da WANG,Li-Yang SUN,Xiao XU,Qing-Yu KONG,Zi-Xiang CHEN,Yong-Yi ZENG,Timothy M. PAWLIK,Wan Yee LAU,Feng SHEN,Zhong CHEN,Tian YANG 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.-

UTAUT2 를 이용한 토탈 패션/뷰티 코디네이션 시스템 수용의도에 관한 연구

어자양(Zi Yang Yu),한수정(Su Jeong Han) 국제e-비즈니스학회 2021 e-비즈니스 연구 Vol.22 No.4

Voice Activity Detection Algorithm based on Improved Radial Basis Function Neural Network

Bao-yuan Chen,Ya-qiong Lan,Jing-yang Liu,Zi-he Li,Xiao-yang Yu 보안공학연구지원센터 2014 International Journal of Signal Processing, Image Vol.7 No.5

Voice activity detection (VAD) is the key of voice recognition, voice synthesis and speech-sound enhancement.For the sake of improve the accuracy and robustness of speech endpoint detection system. Combining the advantages of adaptive genetic algorithm (AGA) and improved radial basis function network (RBF) defects in existing learning methods. This paper presents a comprehensive detection method-- Adaptive genetic algorithm radial basis function network. This method uses adaptive genetic algorithm to simultaneously optimize the center, the width and the structure of RBF network. The method using wavelet analysis to extract the characteristics of the speech signal, use them as an input amount to the radial basis function networks. Establish voice detection system model, this method enhance the accuracy of the detection system and has better robustness.

Cloning and Molecular Characterization of a Novel Rolling-Circle Replicating Plasmid, pK1S-1, from Bacillus thuringiensis subsp. kurstaki K1

Ming Shun Li,Jong Yul Roh,Xueying Tao,Zi Niu Yu,Zi Duo Liu,Qin Liu,Hong Guang Xu,Hee Jin Shim,Yang-Su Kim,Yong Wang,Jae Young Choi,Yeon Ho Je 한국응용곤충학회 2009 한국응용곤충학회 학술대회논문집 Vol.2009 No.05

Bacillus thuringiensis, an entomopathogenic bacterium belonging to the B. cereus group, harbors numerous extra-chromosomal DNA molecules whose sizes range from 2 to 250 kb. In this study, we used a plasmid capture system (PCS) to clone three small plasmids from B. thuringiensis subsp. kurstaki K1 using PCS which were not found in B. thuringiensis subsp. kurstaki HD-1, and determined the complete nucleotide sequence of plasmid pK1S-1 (5.5 kb). Of the six putative open reading frames (ORF2-ORF7) in pK1S-1, ORF2 (MobK1) showed approximately 90% aa identity with the Mob-proteins of pGI2 and pTX14-2, which are rolling circle replicating group VII (RCR group VII) plasmids from B. thuringiensis. In addition, a putative origin of transfer (oriT) showed 95.8% identity with those of pGI2 and pTX14-2. ORF3 (RepK1) showed relatively low aa identity (17.8-25.2%) with the Rep protein coded by RCR plasmids, however. The putative double-strand origin of replication (dso) and single-strand origin of replication (sso) of pK1S-1 exhibited approximately 70% and 64% identities with those of pGI2 and pTX14-2. ORF6 and 7 showed greater than 50% similarities with alkaline serine protease, which belongs to the subtilase family. The other 2 ORFs were identified as hypothetical proteins. To determine the replicon of pK1S-1, seven subclones were contructed in the B. t huringiensis ori-negative pHT1K vector and were electroporated into a plasmid cured B. thuringiensis strain. The 1.6 kb region that included the putative ORF3 (Rep1K), dso and ORF4, exhibited replication ability. These findings identified pK1S-1 as a new RCR group VII plasmid, and determined its replication region.

Characteristics of registered studies for Coronavirus disease 2019 (COVID-19): a systematic review

Ming Yang,Ya-xi Shang,Zi-yu Tian,Min Xiong,Chun-li Lu,Jiang Yue,Zhang Yao,Zhang Ying-ying,Jin Xin-yan,Jin Qiu-bai,Zhang Ying-ying,Willcox Merlin L.,Liu Jian-ping 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.3

Background: The World Health Organization characterized the Coronavirus disease 2019 (COVID-19) as a pandemic on March 11th. Many clinical trials on COVID-19 have been registered, and we aim to review the study characteristics and provide guidance for future trials to avoid duplicated effort. Methods: Studies on COVID-19 registered before March 3rd, 2020 on eight registry platforms worldwide were searched and the data of design, participants, interventions, and outcomes were extracted and analyzed. Results: Three hundred and ninety-three studies were identified and 380 (96.7%) were from mainland China, while 3 in Japan, 3 in France, 2 in the US, and 3 were international collaborative studies. Two hundred and sixty-six (67.7%) aimed at therapeutic effect, others were for prevention, diagnosis, prognosis, etc. Two hundred and two studies (51.4%) were randomized controlled trials. Two third of therapeutic studies tested Western medicines including antiviral drugs (17.7%), stem cell and cord blood therapy (10.2%), chloroquine and derivatives (8.3%), 16 (6.0%) on Chinese medicines, and 73 (27.4%) on integrated therapy of Western and Chinese medicines. Thirty-one studies among 266 therapeutic studies (11.7%) used mortality as primary outcome, while the most designed secondary outcomes were symptoms and signs (47.0%). Half of the studies (45.5%) had not started recruiting till March 3rd. Conclusion: Inappropriate outcome setting, delayed recruitment and insufficient numbers of new cases in China implied many studies may fail to complete. Strategies and protocols of the studies with robust and rapid data sharing are warranted for emergency public health events, helping the timely evidence-based decision-making.

Use of antibiotics and other treatments in Chinese adults with acute cough: An online survey

Xiao-yang Hu,Ru-yu Xia,Michael Moore,Beth Stuart,Wen Ling-Zi,Bertrand Graz,Lai Lily,Liu Jian-Ping,Yu-tong Fei,Merlin Willcox 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.1

Background: Acute respiratory tract infections are common worldwide and there has been a rapid in- crease in antibiotic consumption. This study aimed to identify use of various treatments and their as- sociation with the use of antibiotics and patient reported clinical recovery in Chinese adults with acute cough. Methods: An online survey recruiting people who had recently experienced cough was conducted. Their sociodemographic, clinical characteristics, treatments received and their perceived changes in symptoms were collected. Factors influencing avoidance of antibiotics and improvement in symptoms were explored. Results: A total of 22,787 adults with recent acute cough completed the questionnaire, covering all 34 province-level administrative units in China. Most respondents were male (68.0%), young (89.4%, aged 18–45), educated to university/degree or postgraduate level (44.6%), with a median cough severity of 6/10 on a numerical rating scale. Nearly half of the participants (46.4%) reported using antibiotics, among which 93.1% were for presumed upper respiratory tract infections (URTIs). Pharmacies (48.8%) were the most common source of antibiotics. Fewer patients took antibiotics after taking CHM (14.9%), compared to those who started with home remedies (18.0%), or allopathic non-antibiotic medication (25.0%). An- tibiotics, allopathic non-antibiotic medications, CHM and home remedies were all perceived beneficial in relieving cough. Conclusions: Chinese adult responders report use of a considerable variety of treatments alone or in combination for acute cough. Patient-reported clinical recovery was similar regardless of treatment. There is likely a high proportion of inappropriate use of antibiotics for treatment of simple acute cough. As the majority of respondents did not use antibiotics as a first-line, and use of CHM was associated with relief of cough symptoms and reduction in the use of antibiotics, this presents an important opportunity for prudent antibiotic stewardship in China.

Research on Customer Satisfaction in Cruise Ship Tourism Based on Big Data Analytics

Fang, Yu,Fang, Yi,Liu, Zi-Yang 한국비즈니스학회 2024 비즈니스융복합연구 Vol.9 No.2

This research uses Python technology to capture traveler review data from online travel websites (OTAs) such as Ctrip.com, Dianping.com and TripAdvisor.com to analyze in-depth the satisfaction of international cruise travelers in the Asian market. The research adopts a variety of research methods, including text analysis, word frequency analysis and sentiment analysis, and focuses on three major cruise groups: Carnival Cruise Line's Majestic Princess, Royal Caribbean Cruise Line's Spectrum of the Seas, and Norwegian Joy. The core objective is to gain a comprehensive understanding of the perceived preferences and differentiated needs of Asian cruise travelers. By digging deeper into the big data, we will be able to analyze the challenges and opportunities for improvement for cruise groups in the Asian market. Finally, by combining consumer behavioral research with the tourism market, the study proposes recommendations and directions for international cruise groups to improve customer satisfaction in the Asian market. The study reveals the main factors affecting tourist satisfaction for the three major cruise groups in four areas, including cruise facilities, cruise services, family traveling services and tourist perceptions, which is expected to promote the sustainable development of cruise tourism in Asia.

Nonsingular Fixed-time Consensus Tracking for Heterogeneous Multi-agent Systems With External Disturbances and Actuator Faults

Pu Yang,Yu Ding,Ke-Jia Feng,Zi-Wei Shen 제어·로봇·시스템학회 2024 International Journal of Control, Automation, and Vol.22 No.3

This paper studies the leader-follower consensus tracking for a group of heterogeneous multi-agent systems with nonlinear hybrid order dynamics, external disturbances and actuator faults. First, a novel finite-timeobserver is designed based on a combination of high-order sliding mode and dual layers adaptive rules to realizefast estimation and compensation of disturbances and faults. Then the fixed-time consensus protocols are achievedwith the aid of a novel sliding mode surface. Additionally, the proposed protocols solve the singularity by introducing a continuous sinusoid function. The distributed control protocols are designed for all followers with first-orderor second-order dynamics to achieve synchronization with the leader. Finally, the effectiveness of the algorithm isverified by simulation.

이익조정과 기업가치의 관계에서 조세회피의 매개효과 검증

당옥철(Tang, Yu-zhe),주자운(Zhou, Zi-yun),양규혁(Yang, Kyu-heak) 전북대학교 산업경제연구소 2021 아태경상저널 Vol.13 No.1

본 연구의 목적은 이익조정이 기업가치에 미치는 영향을 분석하고 더불어 이익조정과 기업가치 사이에서 조세회피 행위의 매개역할을 검증하는 것이다. 실증분석을 위하여 2013년부터 2018년까지 국내 코스피와 코스닥 시장에 상장되어 있는 12월 결산인 비금융업 기업을 표본으로 이용하였다. 이익조정은 수정 Jones 모형 (Dechow et al., 1995)으로 측정하였고, 조세회피 행위에 대한 측정치는 Desai and Dharmapala (2006)의 재량적 BTD로, 기업가치는 Tobin"s Q로 측정하였다. 연구결과는 다음과 같다. 첫째, 이익조정이 기업가치에 양(+)의 영향을 미치는 것으로 나타났다. 이는 이익조정을 수행하는 기업의 이익정보가 기업의 건전한 경영상태와 이익의 지속성 및 성장성을 시장에 시그널링하여 기업가치에 긍정적인 영향을 미치고 있음을 의미한다. 둘째, 이익조정과 기업가치 사이에서 조세회피는 매개역할을 하는 것으로 나타났다. 따라서 이익조정은 기업가치에 직접 효과를 가질 뿐만 아니라 조세회피 행위의 감소를 통하여 기업가치를 증가시키는 간접 효과도 가지는 것으로 밝혀졌다. 본 연구는 이익조정과 기업가치 간의 관계를 검토하면서 조세회피를 이익조정이 기업가치에 영향을 미치는 과정 중의 매개변수로 간주하며 조세회피의 매개역할을 검증하였다는 데 그 의의가 있다. 본 연구의 결과는 자본시장에서 이익조정에 대한 정보를 이용할 때 조세회피 요인을 같이 고려할 필요가 있음을 시사한다. The purpose of this study is to analyze the effect of earnings management on corporate value and to verify the mediating effect of tax avoidance between earnings management and corporate value. For the empirical analysis, non-financial companies listed on the Korean KOSPI and KOSDAQ markets from 2013 to 2018 were used as a sample. The earnings management was measured by the Modified Jones model(Dechow et al., 1995), the tax avoidance behavior was measured by the discretionary BTD of Desai and Dharmapala (2006), and the firm value was measured by Tobin"s Q. The research results are as follows. First, it was found that the earnings management had a positive effect on firm values. This means that the earnings information of the company performing the earnings management has a positive effect on the firm value because it signals the company"s sound management status and profit sustainability and growth to the market. Second, it was found that tax avoidance had a mediating effect between earnings management and firm value. Therefore, it was found that earnings management not only has a direct effect on firm value, but also has an indirect effect of increasing firm value through reduction of tax avoidance activities. Unlike previous studies, this study is meaningful in that it examines the relationship between earnings management and firm value and at the same time verifies whether tax avoidance has a mediation effect between these two variables. The results of this study suggest that it is necessary to consider tax avoidance factors when using information on earnings management in the capital market.

OPTIMAL LAUNCHING-INTENTION-AWARE CONTROL STRATEGY FOR AUTOMATED CLUTCH ENGAGEMENT

Yi-yong Yang,Zao-bei Zhu,Xiang-yu Wang,Zheng Chen,Zi-lin Ma 한국자동차공학회 2017 International journal of automotive technology Vol.18 No.3

Clutch engagement control is critical during launching process in a vehicle equipped with an automated manual transmission (AMT), which is a problem including muti-objective optimization and nonlinear control. In this paper, a optimal launching-intention-aware control strategy is proposed for clutch engagement. Firstly, a launching-intention-aware machine (LIAM) based on artificial neural network (ANN) is designed to identify the driver’s launching intentions. Then the optimal laws of clutch engagement for different launching conditions are obtained based on the dynamic programming (DP), which regard friction loss, vehicle shock, angular acceleration of engine and engine torque as the optimizing indexes. Next, a slidingmode controller (SMC) is designed for the clutch engagement. Finally, the performances of the optimal laws and the SMC are validated by the joint simulation of Simulink-AMESim, and the results show that the requirements of vehicle launching are met. The proposed clutch engagement control strategy would provide a better theoretical support for the practical-extended application of AMT.