Nanostructures and nanomechanical properties of ion-irradiated HOPG

Zhou Yuying,Wang Ying,Lei Qiantao,Huang Qing,Zhang Wei,Yan Long 한국탄소학회 2021 Carbon Letters Vol.31 No.4

Highly Oriented Pyrolytic Graphite (HOPG) was half covered using aluminum foil and exposed to irradiation with 70 keV C+ ions at room temperature (~25 ℃). The surface layer (height=178.3±4.7 nm) of the irradiated area was destroyed, many nano-sized dendritic protrusions were observed and smooth inner layer was exposed. The peak area ratio (ID/IG) in Raman spectra increased after ion irradiation, indicating that a change in atomic structure and transformation from the sp2 to sp3 phase. The mechanical properties were explored using atomic force microscopy in peakforce mode, which revealed that the Young’s modulus of the exposed inner layer was similar to unirradiated area, while the Young’s modulus of the dendritic protrusions was higher. There fndings provid

The Inhibitory Effect of Ginseng Pectin on L-929 Cell Migration

Yuying Fan,Hairong Cheng,Dan Liu,Xu Zhang,Bo Wang,Lin Sun,Guihua Tai,Yifa Zhou 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.5

We tested the effects of ginseng pectin prepared by enzymatic hydrolysis of ginseng polysaccharides on cell migration. Ginseng pectin impaired the migration of L-929 cells and reduced their migration speed by up to 50% of control in the presence or absence of serum, suggesting it worked on both serum-dependent and serum-independent migration pathways. Ginseng pectin impaired cell migration via decreased cell spreading. These findings represent a significant contribution towards understanding the bioactivities of ginseng polysaccharides and applying them to health food and medicine.

Self-supported ZIF-coated Co2P/V3P bifunctional electrocatalyst for high-efficiency water splitting

Yuying Yang,Jingyue Yang,Qin Zhou,Dalan Qian,Yaling Xiong,Zhongai Hu 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.110 No.-

Exploring high-efficiency dual-functional electrocatalysts to drive electrochemical water splitting is ofgreat importance for advancement of renewable hydrogen energy. Herein, a hierarchical core–shell structureelectrocatalyst ZIF-Co2P/V3P is in situ grown on Ni foam (abbreviated as ZIF-Co2P/V3P@NF) by a stepwisemethod. Firstly, Co, V layered double hydroxides (CoV-LDHs) is grown directly on Ni foam (NF)substrate by solvothermal method. Secondly, CoV-LDHs@NF is transferred into 2-MeIm solution andits surface is coated with a layer of imidazolate zeolite skeleton (ZIF). Finally, ZIF-Co2P/V3P@NF catalystis obtained by low-temperature phosphorization method. The performance of hydrogen evolution reaction(HER) and oxygen evolution reaction (OER) can be adjusted by tuning molar ratio of Co/V, and theoptimized ZIF-Co2P/V3P@NF-2 manifests superior performance due to its core–shell structure coveredby ZIF skeleton, rich heterogeneous interfaces, as well as the positive synergistic interaction betweenthe Co2P and V3P. The overpotentials are only 57 mV@10 mA cm2 for HER and 261 mV@10 mA cm2for OER. Remarkably, the alkaline electrolyzer assembled with ZIF-Co2P/V3P@NF-2 catalyst acquires asmall operating voltage of 1.54 V to drive the current density of 10 mA cm2 and displays excellentlong-term durability. This work provides a novel opinion for design and preparation of non-noble metalelectrocatalysts.

Effect of FTY-720 on Pulmonary Fibrosis in Mice via the TGF-β1 Signaling Pathway and Autophagy

Jin Yuying,Liu Weidong,Gao Ge,Song Yilan,Liu Hanye,Li Liangchang,Zhou Jiaxu,Yan Guanghai,Cui Hong 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.4

We investigated whether FTY-720 might have an effect on bleomycin-induced pulmonary fibrosis through inhibiting TGF-β1 pathway, and up-regulating autophagy. The pulmonary fibrosis was induced by bleomycin. FTY-720 (1 mg/kg) drug was intraperitoneally injected into mice. Histological changes and inflammatory factors were observed, and EMT and autophagy protein markers were studied by immunohistochemistry and immunofluorescence. The effects of bleomycin on MLE-12 cells were detected by MTT assay and flow cytometry, and the related molecular mechanisms were studied by Western Blot. FTY-720 considerably attenuated bleomycin-induced disorganization of alveolar tissue, extracellular collagen deposition, and α-SMA and E-cadherin levels in mice. The levels of IL-1β, TNF-α, and IL-6 cytokines were attenuated in bronchoalveolar lavage fluid, as well as protein content and leukocyte count. COL1A1 and MMP9 protein expressions in lung tissue were significantly reduced. Additionally, FTY- 720 treatment effectively inhibited the expressions of key proteins in TGF-β1/TAK1/P38MAPK pathway and regulated autophagy proteins. Similar results were additionally found in cellular assays with mouse alveolar epithelial cells. Our study provides proof for a new mechanism for FTY-720 to suppress pulmonary fibrosis. FTY-720 is also a target for treating pulmonary fibrosis.

A Novel Approach for the Unit Commitment with Vehicle-to-grid

Jin, Lei,Yang, Huan,Zhou, Yuying,Zhao, Rongxiang Journal of International Conference on Electrical 2013 Journal of international Conference on Electrical Vol.2 No.3

The electrical vehicles (EV) with vehicle-to-grid (V2G) capability can be used as loads, energy sources and energy storage in MicroGrid integrated with renewable energy sources. The output power of generators will be reallocated in the considering of V2G. An intelligent unit commitment (UC) with V2G for cost optimization is presented in this paper. A new constraint of UC with V2G is considered to satisfy daily use of EVs. A hybrid optimiza-tion algorithm combined Binary Particle Swarm Optimization (BPSO) with Lagrange Mul-tipliers Method (LMM) is proposed. The difference between results of UC with V2G and UC without V2G is presented.

Some convergence theorems for mappings of asymptotically quasi-nonexpansive type in Banach spaces

Shin-sen Chang,Yuying Zhou 한국전산응용수학회 2003 Journal of applied mathematics & informatics Vol.12 No.1-2

An Engineered Outer Membrane-Defective Escherichia coli Secreting Protective Antigens against Streptococcus suis via the Twin-Arginine Translocation Pathway as a Vaccine

( Wenyu Li ),( Fan Yin ),( Zixuan Bu ),( Yuying Liu ),( Yongqing Zhang ),( Xiabing Chen ),( Shaowen Li ),( Lu Li ),( Rui Zhou ),( Qi Huang ) 한국미생물 · 생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.3

Live bacterial vector vaccines are one of the most promising vaccine types and have the advantages of low cost, flexibility, and good safety. Meanwhile, protein secretion systems have been reported as useful tools to facilitate the release of heterologous antigen proteins from bacterial vectors. The twin-arginine translocation (Tat) system is an important protein export system that transports fully folded proteins in a signal peptide-dependent manner. In this study, we constructed a live vector vaccine using an engineered commensal Escherichia coli strain in which amiA and amiC genes were deleted, resulting in a leaky outer membrane that allows the release of periplasmic proteins to the extracellular environment. The protective antigen proteins SLY, enolase, and Sbp against Streptococcus suis were targeted to the Tat pathway by fusing a Tat signal peptide. Our results showed that by exploiting the Tat pathway and the outer membrane-defective E. coli strain, the antigen proteins were successfully secreted. The strains secreting the antigen proteins were used to vaccinate mice. After S. suis challenge, the vaccinated group showed significantly higher survival and milder clinical symptoms compared with the vector group. Further analysis showed that the mice in the vaccinated group had lower burdens of bacteria load and slighter pathological changes. Our study reports a novel live bacterial vector vaccine that uses the Tat system and provides a new alternative for developing S. suis vaccine.

Evaluation of the Front-End AC/DC Converter Circuits for Medium-Voltage-Connected Power Supply Systems

Haihong Long,Jinyi Deng,Xin Wu,Yi Zhou,Yuying Wu,Dehong Xu 전력전자학회 2023 ICPE(ISPE)논문집 Vol.2023 No.-

For large power DC loads such as data centers, EV charging stations, light rail, etc., the medium-voltage-connected power supply is promising since it eliminates utility-frequency transformers, reduces power conversion stages and distribution loss and has a smaller size. In this paper, the front-end AC/DC conversion stage of the medium-voltage-connected power supply is investigated. Five AC/DC converter circuits are compared with respect to the efficiency and the power density by optimizing the switching frequency, the filter inductor and the heat sink.

The effective mechanism of the polysaccharides from Panax ginseng on chronic fatigue syndrome

Jia Wang,Chengxin Sun,Yan Zheng,Hongling Pan,Yifa Zhou,Yuying Fan 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.4

Ginseng acidic polysaccharide WGPA isolatedfrom the root of Panax ginseng C. A. Meyer was fractionatedinto WGPA-A and WGPA-N by anion-exchangechromatography. The antifatigue activity of ginseng acidicpolysaccharide WGPA has been reported in our previousresearch. This present study was designed to identify itsactive component and elucidate the mechanism for preventingchronic fatigue syndrome (CFS). WGPA, WGPAAand WGPA-N were orally administered to mice oncedaily for 15 days. The effects of these compounds onphysiological biomarkers of oxidative stress and on themorphology of the mitochondria in striated skeletal musclewere assessed. The results of forced swimming testinducedindicated that WGPA and WGPA-A couldlengthen the swimming time, while WGPA-N could not. Inaddition, malondialdehyde and lactate dehydrogenase levelsin serum were enhanced; while those of superoxidedismutase and glutathione peroxidase were lowered. Interestingly, the structural degeneration of mitochondriawere all ameliorated. These findings suggested thatWGPA-A is the active component of WGPA, it might havepotential therapeutic effects for CFS and the oxidative stress might be involved in the pathogenesis. Our resultsalso provided essential data for a better understanding ofthe antifatigue effects of P. ginseng extracts.

The effective mechanism of the polysaccharides from Panax ginseng on chronic fatigue syndrome

Wang, Jia,Sun, Chengxin,Zheng, Yan,Pan, Hongling,Zhou, Yifa,Fan, Yuying 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.4

Ginseng acidic polysaccharide WGPA isolated from the root of Panax ginseng C. A. Meyer was fractionated into WGPA-A and WGPA-N by anion-exchange chromatography. The antifatigue activity of ginseng acidic polysaccharide WGPA has been reported in our previous research. This present study was designed to identify its active component and elucidate the mechanism for preventing chronic fatigue syndrome (CFS). WGPA, WGPA-A and WGPA-N were orally administered to mice once daily for 15 days. The effects of these compounds on physiological biomarkers of oxidative stress and on the morphology of the mitochondria in striated skeletal muscle were assessed. The results of forced swimming test-induced indicated that WGPA and WGPA-A could lengthen the swimming time, while WGPA-N could not. In addition, malondialdehyde and lactate dehydrogenase levels in serum were enhanced; while those of superoxide dismutase and glutathione peroxidase were lowered. Interestingly, the structural degeneration of mitochondria were all ameliorated. These findings suggested that WGPA-A is the active component of WGPA, it might have potential therapeutic effects for CFS and the oxidative stress might be involved in the pathogenesis. Our results also provided essential data for a better understanding of the antifatigue effects of P. ginseng extracts.