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( Na Luo ),( Guan Li ),( Yong Qing Li ),( Xiong Wei Fan ),( Yue Qun Wang ),( Xiang Li Ye ),( Xiao Yan Mo ),( Jun Mei Zhou ),( Wu Zhou Yuan ),( Ming Tan ),( Hua Ping Xie ),( Karen Ocorr ),( Rolf Bodmer 생화학분자생물학회 2010 BMB Reports Vol.43 No.5
The sterile alpha motif (SAM) is a putative protein interaction domain involved in a wide variety of biological processes. Here we report the identification and characterization of a novel gene, SAMD4B, which encodes a putative protein of 694 amino acids with a SAM domain. Northern blot and RT-PCR analysis showed that SAMD4B is widely expressed in human embryonic and adult tissues. Transcriptional activity assays show SAMD4B suppresses transcriptional activity of L8G5-luciferase. Over-expression of SAMD4B in mammalian cells inhibited the transcriptional activities of activator protein-1 (AP-1), p53 and p21, and the inhibitory effects can be relieved by siRNA. Deletion analysis indicates that the SAM domain is the main region for transcriptional suppression. The results suggest that SAMD4B is a widely expressed gene involved in AP-1-, p53-and p21-mediated transcriptional signaling activity. [BMB reports 2010; 43(5): 355-361]
Huang, Na,Cai, Yongjie,Zhuang, Mingyu,Zhou, Yi,Zhou, Jun Council on Tall Building and Urban Habitat Korea 2021 International journal of high-rise buildings Vol.10 No.1
Being the origin of Shanghai City, the Old Town presents a high-density spatial texture, a characteristic of local living conditions in the Shanghai context. However, the Old Town is faced with competing interests: the preservation of historic urban features and the improvement of contemporary living conditions. In view of its high density and poor living conditions, this paper focuses on two types of blocks for urban design research, and proposes two spatial regeneration strategies, as "overlapping lilong" and "texture continuity". It is expected to inherit the regional characteristics of urban space, improve the plot ratio and supplement the mix of functions, through the translation of the traditional lilong typology and the reproduction of historical streets and alleys, so as to provide operable spatial strategies and design methods for the organic renewal of Old Town and other historic districts.
Curcumin derivative HBC induces autophagy through activating AMPK signal in A549 cancer cells
Guang-Zhou Zhou,Gang-Chun Sun,Shuai-Na Zhang 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.1
Curcumin exhibits growth-suppressive activity against a variety of cancer cells, but low bioavailability restricts its application in chemotherapeutic trials. A synthetic curcumin derivative hydrazinobenzoylcurcumin (HBC) had been indicated that it could inhibit cell growth in A549 lung cancer cells via cell autophagy in our previous report. The present research aims to investigate the effect of HBC on the AMP-activated protein kinase (AMPK) signaling and whether AMPK signaling is involved in HBC-induced autophagy in A549 cells. The autophagy inhibitor 3-MA was used to block the inhibitory effect of HBC on the growth of A549 cells by acridine orange assay. The phosphorylations of AMPK and its downstream factor Acetyl CoA Carboxylase (ACC) were characterized in HBCtreated A549 cells with western blot analysis. Moreover, pharmacological inhibition of the AMPK signaling pathway by Compound C impairs the autophagyinducing effect of HBC. Our data indicates that HBC could activate the AMPK signal and induce AMPKmediated autophagy, which plays an important role in the inhibiting effect of HBC in A549 cells.
“以概念为本”和“大观念”:两种英语教学理论与模式的比较研究
董娜(Na Dong),周志伟(Zhiwei Zhou),周洁(Jie Zhou),王雪洁(Xuejie Wang) YIXIN 출판사 2024 Journal of Humanities and Social Sciences Vol.2 No.3
Concept-Based Curriculum and Instruction is one of the theoretical sources in the West of Big-Idea English teaching method. These two theories and teaching patterns have common in the purpose and the key notions and in the theoretical structure, the definition of the nature of English as a subject, the teaching design procedures, and the way of cultivating students’ core qualities, they are different. A comparative study of these two English teaching theories and patterns proves that Concept-Based Curriculum and Instruction can offer inspiration to the development of Big-Idea English teaching method. “以概念为本”的课程建设和教学模式是我国基于“大观念”的英语教学理论和模式的西方渊源之一。这两种教学理论和模式在创立主旨和核心理念上有共同点,同时,在理论架构、学科本质界定、理论实践应用方式和核心素养培育方面又存在差异。对这两种英语教学理论和模式进行对比分析后发现,“以概念为本”的理论和模式可以为发展中的“大观念”理论和模式提供借鉴,促进其完善。
Traffic-Aware Relay Sleep Control for Joint Macro-Relay Network Energy Efficiency
Na Deng,Ming Zhao,Jinkang Zhu,Wuyang Zhou 한국통신학회 2015 Journal of communications and networks Vol.17 No.1
With the ever growing demand of data applications, the joint macro-relay networks are emerging as a promising heterogeneous deployment to provide coverage extension and throughput enhancement. However, the current cellular networks are usually designed to be performance-oriented without enough considerations on the traffic variation, causing substantial energy waste. In this paper, we consider a joint macro-relay network with densely deployed relay stations (RSs), where the traffic load varies in both time and spatial domains. An energy-efficient scheme is proposed to dynamically adjust the RS working modes (active or sleeping) according to the traffic variations, which is called traffic-aware relay sleep control (TRSC). To evaluate the performance of TRSC,we establish an analytical model using stochastic geometry theory and derive explicit expressions of coverage probability, mean achievable rate and network energy efficiency (NEE). Simulation results demonstrate that the derived analytic results are reasonable and the proposed TRSC can significantly improve the NEE when the network traffic varies dynamically.
The Research and Application of a Big Data Storage Model
Na Liu,Jianfei Zhou 보안공학연구지원센터 2015 International Journal of Database Theory and Appli Vol.8 No.4
In the big data environment, there are many new demands with data storage, the traditional data storage mode which based on relational database cannot meet these needs, many application systems tend to use NoSQL to solve the problem of big data storage. However, NoSQL gave up on the relationship between operation support, so that part of existing application system is difficult to use the simple way of transplantation. This thesis with reference to some typical existing big data storage scheme, we presents a big data compatible with relational storage model storage scheme, this scheme can not only meet the big data storage requirements, but also can support the most relational operation, so that the original system based on relational database can easily be ported to new storage schemes in.
HGFK1 is Associated with a Better Prognostis and Reverses Inhibition by Gefitinib in NSCLC Cases
Zhou, Xiao-Hui,Tang, Li-Na,Yue, Lu,Min, Da-Liu,Yang, Yi,Huang, Jian-An,Shen, Zan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Purpose: Non small cell lung cancer (NSCLC) is the leading worldwide source of cancer-related deaths. Although some drugs targeting EGFR mutations have been developed, most advanced cases are still incurable. New targets for anticancer drugs are demanded. The kringle 1 domain of hepatocellular growth factor alpha chain (HGFK1) is a potent anti-angiogenesis factor. It has also emerged as a potential anticancer factor in hepatocellular carcinoma (HCC). The expression of HGFK1 protein in patients with NSCLC has not been reported to date. Method: Here, we assessed HGFK1 expression by Western blotting in 103 cases with advanced NSCLC to investigate the impact of HGFK1 on survival. Results: Results revealed 33 (30.1%) patients were classified as high expressors, this being significantly associated with less remote metastasis (P = 0.002) but not with lymph node metastasis (P = 0.062). There was also a significant association between HGFK1 expression and tumor size (P = 0.025) as well as clinical stage (P = 0.012). Kaplan-Meier survival analysis showed that both overall survival (OS) and progression free survival (PFS) of patients with HGFK1 expression were longer than those of patients without HGFK1 expression (P = 0.004 and P = 0.001 respectively). HGFK1 reversed gefitinib inhibition in the resistent NSCLC cell line A431/GR but did not inhibit the proliferation of NSCLC cells A431 and A431/GR directly. Reversion of gefitinib inhibition in A431/GR cells by HGFK1 was related to decreased phosphorylation of ERK and STAT5. Conclusions: HGFK1 may be a useful prognostic factor of advanced NSCLC patients and a potential drug for gefitinib resistant patients.
Zhou, Lei,Yu, Lan,Feng, Zhen-Zhong,Gong, Xiao-Meng,Cheng, Ze-Nong,Yao, Nan,Wang, Dan-Na,Wu, Shi-Wu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.10
Background: Gastric cancer is the second leading cause of cancer-related death in Asia, and the majority type is gastric adenocarcinoma (GAC). Most GAC patients die of recurrence and metastasis. Cancer stem cells (CSCs) have been thought to be responsible for the initiation, development, metastasis, and ultimately recurrence of cancer. In this study, we aimed to investigate expression and clinical significance of CSCs markers, CD133 and Lgr5, and vasculogenic mimicry (VM) in primary GAC. Materials and Methods: Specimens from 261 Chinese patients with follow-up were analyzed for CD133, Lgr5 protein expression and VM by immunohistochemical and histochemical staining. The Pearson Chi's square test was used to assess the associations among the positive staining of these markers and clinicopathological characteristics. Postoperative overall survival time was were studied by univariate and multivariate analyses. Results: In GAC tissues, positive rates of 49.0%, 38.7%, and 26.8% were obtained for CD133, Lgr5, and VM, respectively. The mean score of microvessel density (MVD) was $21.7{\pm}11.1$ in GAC tissues. There was a significantly difference between the positive and negative groups. There was a positive relationship between the VM, the expression of CD133 and Lgr5, and the score of MVD and the grades of tumor, lymph node metastasis, TNM stages (all p<0.05). The overall mean survival time of the patients with CD133, Lgr5, VM, and MVD (${\geq}22$) positive expression was lower than that of patients with negative expression. The score of MVD, positive expression of CD133 and VM were independent prognostic factors of GAC (p<0.05). Conclusions: VM, and expression of CD133, Lgr5, and the score of MVD are related to grades of tumor, lymph node metastasis, TNM stages, and overall mean survival time. It is suggested that CSCs and VM could play an important role in the evolution of GAC.