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RISS 인기검색어
- 검색키워드
- 저자 : Zhou Chao Ying (검색결과 15 건)
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Zhou Ling,Li Ying-tao,Chen Jin,Yang Chao-shan,Deng Zhi-ping 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.10
In order to locate damage posotion and quantify damage degree of transmission tower, the method of damage identification of transmission tower based on flexibility matrix and signalterm amplitude vector was proposed, by combining flexibility matrix method of damage identification and time-frequency analysis method of domain vibration signal. Firstly, the coefficient equation about modal parameters and damage parameters was established, according to the linear relationship between flexibility matrix elements and structure parameters. Then, by Wigner-Ville Distribution (WVD) signalterm analytical deduction of free vibration response of the damping structure, the responding function relation between signalterm amplitude and model parameters was founded. Finally, the coefficient equation was solved by substituting mode shape vector with signalterm amplitude vector, avoiding the structural modal parameters identification, the damage location and extent of transmission tower was detected once and for all. The numerical example analysis of single tower model and tower-line system shows that, the proposed method with good anti-noise performance can accurately detect the extent of single or multiple damage of current structure by a single measurement.
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Apoptotic Effects of psiRNA-STAT3 on 4T1 Breast Cancer Cells in Vitro
Zhou, Yue,Tian, Lin,Zhang, Ying-Chao,Guo, Bao-Feng,Zhou, Qing-Wei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
Background: The aim of this study was to investigate the effect of a Lipofectamine2000 (Life2000) Transfection Reagent transfected psiRNA-STAT3 plasmid on 4T1 breast cancer cells. Materials and Methods: MTT was used to detect the cell proliferation of breast cancer 4T1 cells at different periods (0h, 6h, 8h, 10h); the cell cycle was assessed by flow cytometry; variation of apoptosis and mitochondrial membrane potential was observed under a fluorescence microscope; immunohistochemical staining was used to determine the expression of caspase-3 and cyclin-D1 protein. Results: An obvious effect of inhibition to 4T1 cancer cells could be observed at 8h after the psiRNA-STAT3 was transfected. Typical alterations of apoptotic morphological features were visible in the psiRNA-STAT3 treatment group. Mitochondrial membrane potential decreased significantly, the number of cells was increased in G0/G1 phase, and the number of cells was decreased in S phase, and the data were statistically significant (p<0.05), compared with the Scramble and Mock groups. Expression of caspase-3 protein was increased significantly, while that of cyclin D1 was significantly decreased. Conclusions: Life2000 transfected psiRNA-STAT3 plasmid can inhibit 4T1 tumor cell proliferation and promote apoptosis of 4T1 tumor cells, which process depends on the regulation of expression of cyclin D1 and caspase-3 protein.
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Ying Gu,Yadong Li,Zihao Zhou,Songbo Ren,Chao Kong 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.3
This study aims to investigate the magnitude and distribution of welding residual stresses in orthotropic steel decks stiff ened with U-shaped ribs. Numerical simulation of the welding residual stresses is performed using the thermal elastic–plastic fi nite element method. The residual stresses are subsequently measured using the hole-drilling strain-gage method. Based on the results of this study, it can be determined that: (1) The longitudinal welding residual stresses ( σ z ) in the weld zones are tensile stresses, where the peak value exceeds the minimum yield strength ( f yl ); however, relatively low compressive stresses exist in the areas located far away from the welds; (2) The stress gradient in the weld zone is steep, and the widths of the areas experiencing tensile stress are narrow; (3) In the case of the upper surface of the deck, the weld that is fi rst deposited has the highest peak stress, while similar stresses are determined for the remaining welds. In the case of the lower surface of the deck, the peak stress in the weld zones is greater than that on the upper surface; (4) In the case of the weld zone of the U-shaped ribs, the tensile stresses reach up to 1.15 f yl ; however, at locations a short distance away from the welds, the σ z varies from tensile to compressive, and fi nally transforms into a small tensile stress at the base of the U-shaped ribs. In addition, the simulated and measured σ z are compared, and the deviation between them is analyzed.
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Estrogen Receptor α Roles in Breast Cancer Chemoresistance
Xu, Chao-Yang,Jiang, Zhi-Nong,Zhou, Ying,Li, Jia-Jia,Huang, Li-Ming Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7
Resistance to chemotherapy treatment, which may lead to limited efficacy of systemic therapy in breast cancer patients, is multifactorial. Among the mechanisms of resistance to chemotherapy treatment, there are those closely related to estrogen receptor ${\alpha}$, P-glycoprotein, multidrug resistance-related protein, glutathione S-transferase pi and topoisomerase-II. $ER{\alpha}$ is ligand-activated transcription factor that regulates gene expression and plays a critical role in endocrine signaling. In previous preclinical and clinical studies, positive $ER{\alpha}$ expression in breast cancer cells was correlated with decreased sensitivity to chemotherapy. This article reviews current knowledge on the predictive value of $ER{\alpha}$ with regard to response to chemotherapy. Better understanding of its role may facilitate patient selection of therapeutic regimens and lead to optimal clinical outcomes.
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Peng Xie,Chao Ying Zhou 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.3
Rain-wind-induced vibration (RWIV) appeared on cable stayed bridges involves complicated fluid and structure interactions and its mechanism is not fully understood. It is believed that the upper-rivulet which is often seen when the RWIV occurs plays an important role. In this paper, a numerical investigation on the effects of the upper rivulet on the aerodynamic forces of the cable and the interaction between the fluid flow and the cable oscillation is carried out where the cable with the upper-rivulet is modeled by a circular cylinder with an arch attachment. The Reynolds number of 6.8×104 is selected. The large-eddy simulation (LES) method with Smagorinsky-Lilly modeling is employed to simulate the 3-D turbulent flow field, and a moving mesh method is introduced to deal with the oscillation of the cylinder. The aerodynamic forces on the cylinder and the flow patterns around the cylinder are analyzed for both steady and oscillation status of the cylinder with the rivulet attachment in different position angle ranged from 0˚ to 60˚. The results show that the aerodynamic forces on the cylinder change largely with the position angle of the rivulet attachment. In the steady cases, a uniform recirculation flow along the axial direction of the cylinder forms behind the cylinder; whereas in the oscillation cases, a 3-D periodical recirculation flow appears along the axial direction. The scales of these recirculation zones are influenced by both the position angle of the rivulet and the dynamic status of the cylinder. The results also show that there exists a rivulet position angle where the aerodynamic force on the cable and flow pattern around the cable both change dramatically. This critical position angle is found to be 45˚ for the cases studied.
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Miao, Guo-Ying,Zhou, Xin,Zhang, Xin,Xie, Yi,Sun, Chao,Liu, Yang,Gan, Lu,Zhang, Hong Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
The effects of carbon-ion irradiation on cancer cell telomere function have not been comprehensively studied. In our previous report cancer cells with telomere dysfunction were more sensitive to carbon-ion irradiation, but the underlying mechanisms remained unclear. Here we found that telomerase activity was suppressed by carbon-ion irradiation via hTERT down-regulation. Inhibition of telomere activity by MST-312 further increased cancer cell radiosensitivity to carbon-ion radiation. hTERT suppression caused by either carbon-ion irradiation or MST-312 impaired mitochondrial function, as indicated by decreased membrane potential, mtDNA copy number, mitochondrial mass, total ATP levels and elevated reactive oxygen species (ROS). PGC-$1{\alpha}$ expression was repressed after carbion-ion irradiation, and hTERT inhibition by MST-312 could further exacerbate this effect. Lowering the mitochondrial ROS level by MitoTEMPO could partially counteract the induction of cellular senescence induced by carbon-ion radiation and MST-312 incubation. Taken together, the current data suggest that telomere-mitochondrion links play a role in the induction of senescence in MCF-7 cells after carbon-ion irradiation.
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Shams Ul Islam,Raheela Manzoor,Zhou Chao Ying,Mohammad Mehdi Rashdi,A. Khan 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.2
A two-dimensional numerical study is carried out to analyze the drag reduction and vortex shedding suppression behind a square cylinder in presence of splitter plate arranged in upstream, downstream and both upstream and downstream location at low Reynolds number (Re = 160). Computations are performed using a Single relaxation time lattice Boltzmann method (SRT-LBM). Firstly, the code is validated for flow past a single square cylinder. The obtained results are compared to those available in literature and found to be in good agreement. Numerical simulations are performed in the ranges of 1 ≤ L ≤ 4 and 0 ≤ g ≤ 7, where L and g are the length of splitter plate and gap spacing between the splitter plate and main square cylinder, respectively. The effect of these parameters on the vortex shedding frequency, time-trace analysis of drag and lift coefficients, power spectra analysis of lift coefficient, vorticity contours visualization and force exerted on the cylinder are quantified together with the observed flow patterns around the main cylinder and within the gap spacings. The observed results are also compared with a single square cylinder without splitter plate. We found that at some combinations of L and g, the mean drag coefficient and Strouhal number reach either its maximum or minimum value. It is found that the drag is reduced up to 62.2 %, 13.3 % and 70.2 % for upstream, downstream and dual splitter plates, respectively as compared to a single square cylinder (without splitter plate). In addition, in this paper we also discussed the applications of SRT-LBM for suppression of vortex shedding and reduction of the drag coefficients.
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Hamid Rahman,Shams-Ul-Islam,Zhou Chao Ying,Tanvir Kiyani,Suvash C. Saha 대한토목학회 2015 KSCE JOURNAL OF CIVIL ENGINEERING Vol.19 No.1
Flow patterns and aerodynamic characteristics behind three side-by-side square cylinders has been found depending upon theunequal gap spacing (g1= s1/d and g2= s2/d) between the three cylinders and the Reynolds number (Re) using the Lattice Boltzmannmethod. The effect of Reynolds numbers on the flow behind three cylinders are numerically studied for 75 ≤ Re ≤ 175 and chosenunequal gap spacings such as (g1, g2) = (1.5, 1), (3, 4) and (7, 6). We also investigate the effect of g2 while keeping g1 fixed forRe = 150. It is found that a Reynolds number have a strong effect on the flow at small unequal gap spacing (g1, g2) = (1.5, 1.0). It isalso found that the secondary cylinder interaction frequency significantly contributes for unequal gap spacing for all chosen Reynoldsnumbers. It is observed that at intermediate unequal gap spacing (g1, g2) = (3, 4) the primary vortex shedding frequency plays a majorrole and the effect of secondary cylinder interaction frequencies almost disappear. Some vortices merge near the exit and as a resultsmall modulation found in drag and lift coefficients. This means that with the increase in the Reynolds numbers and unequal gapspacing shows weakens wakes interaction between the cylinders. At large unequal gap spacing (g1, g2) = (7, 6) the flow is fullyperiodic and no small modulation found in drag and lift coefficients signals. It is found that the jet flows for unequal gap spacingstrongly influenced the wake interaction by varying the Reynolds number. These unequal gap spacing separate wake patterns fordifferent Reynolds numbers: flip-flopping, in-phase and anti-phase modulation synchronized, in-phase and anti-phase synchronized. It is also observed that in case of equal gap spacing between the cylinders the effect of gap spacing is stronger than the Reynoldsnumber. On the other hand, in case of unequal gap spacing between the cylinders the wake patterns strongly depends on both unequalgap spacing and Reynolds number. The vorticity contour visualization, time history analysis of drag and lift coefficients, powerspectrum analysis of lift coefficient and force statistics are systematically discussed for all chosen unequal gap spacings and Reynoldsnumbers to fully understand this valuable and practical problem.
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