http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Zhiyang Xie (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Xu Zhiyang,Zhou Kaixiang,Wang Zhenni,Liu Yang,Wang Xingguo,Gao Tian,Xie Fanfan,Yuan Qing,Gu Xiwen,Liu Shujuan,Xing Jinliang 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Ovarian cancer (OC) is the most lethal gynecologic tumor and is characterized by a high rate of metastasis. Challenges in accurately delineating the metastatic pattern have greatly restricted the improvement of treatment in OC patients. An increasing number of studies have leveraged mitochondrial DNA (mtDNA) mutations as efficient lineage-tracing markers of tumor clonality. We applied multiregional sampling and high-depth mtDNA sequencing to determine the metastatic patterns in advanced-stage OC patients. Somatic mtDNA mutations were profiled from a total of 195 primary and 200 metastatic tumor tissue samples from 35 OC patients. Our results revealed remarkable sample-level and patient-level heterogeneity. In addition, distinct mtDNA mutational patterns were observed between primary and metastatic OC tissues. Further analysis identified the different mutational spectra between shared and private mutations among primary and metastatic OC tissues. Analysis of the clonality index calculated based on mtDNA mutations supported a monoclonal tumor origin in 14 of 16 patients with bilateral ovarian cancers. Notably, mtDNA-based spatial phylogenetic analysis revealed distinct patterns of OC metastasis, in which a linear metastatic pattern exhibited a low degree of mtDNA mutation heterogeneity and a short evolutionary distance, whereas a parallel metastatic pattern showed the opposite trend. Moreover, a mtDNA-based tumor evolutionary score (MTEs) related to different metastatic patterns was defined. Our data showed that patients with different MTESs responded differently to combined debulking surgery and chemotherapy. Finally, we observed that tumor-derived mtDNA mutations were more likely to be detected in ascitic fluid than in plasma samples. Our study presents an explicit view of the OC metastatic pattern, which sheds light on efficient treatment for OC patients.
-
Qun He,Michael C. H. Yam,Zhiyang Xie,Xue-Mei Lin,Kwok-Fai Chung 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.44 No.4
In this study, the classical J2 flow theory is explicitly proved to be inappropriate to describe the plastic behaviour of structural steels under different stress states according to the reported test results. A numerical framework of the characterization of the strain hardening and ductile fracture initiation involving the effect of stress states, i.e., stress triaxiality and Lode angle parameter, is proposed based on the mechanical response of structural steels under monotonic loading. Both effects on strain hardening are determined by correction functions, which are implemented as different modules in the numerical framework. Thus, other users can easily modify them according to their test results. Besides, the ductile fracture initiation is determined by a fracture locus in the space of stress triaxiality, Lode angle parameter, and fracture strain. The numerical implementation of the proposed model and the corresponding code are provided in this paper, which are also available on GitHub. The validity of the numerical procedure is examined through single element tests and the accuracy of the proposed model is verified by existing test results.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
