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Chunyu Zhang,Mengjun Chen,Rentai Liu,Xiuhao Li,Jia Yan,Zhijing Zhu,Fengshuai Fan 대한토목학회 2022 KSCE Journal of Civil Engineering Vol.26 No.12
Operating tunnels are often located in complex geological conditions and are prone to various types of damage. Even after structural repair, the repaired material may be vulnerable to secondary damage. It is difficult to effectively repair operating tunnel damage. Hence, developing high-performance repair materials for tunnel structures is critical. This study aimed to develop repair materials by studying the synergistic effects of fiber and polymers. The effectof polyvinyl alcohol (PVA) fiber and PTB (COMPAKTUNA.PRO) emulsion on the compressive strength (40 × 40 × 40 mm, GB/T 17671-2020), flexural strength (40 × 40 × 160 mm, GB/T 17671-2020), uniaxial tensile properties (330 × 60 × 13 mm, JC/T 2461-2018), bond strength (40 × 40 × 160 mm, JC/T 2537-2019), rapid chloride migration coefficient (ϕ100 × 50 mm, GB/T 50082-2009), porosity (40 × 40 × 40 mm, SY/T 6490-2014), and scanning electron microscopy (less than 1 cm3, GB/T 27788-2020) was analysed. The test was completed in the laboratory of our school, and the average value of three specimens per mix ratio was taken. The results indicate that both PVA fiber and PTB emulsion addition reduce the compressive strength but significantly increase the flexural strength, tensile strength, and ultimate tensile strain of cementitious composite. The compressive-to-flexural strength ratio decreases, and the uniaxial compression toughness index increases. The cementitious composites exhibit good integrity after damage. The influence of the PVA fiber is more potent than that of the PTB emulsion. The PTB emulsion increases the impermeability and bonding strength of the cementitious composite and can improve the disadvantages caused by adding the PVA fibers. The bridging effect of the PVA fiber and the membrane-forming effect of the PTB emulsion together influence the performance and cause a synergistic effect to achieve superposition and complementation of advantages. The optimal content of the PVA fiber and PTB emulsion under the synergistic effect can be obtained. The findings can provide a theoretical basis for the optimal design and practical application of restoration materials.
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Measurement and data processing method of machined surface for assembly performance prediction
Huan Guo,Zhijing Zhang,Muzheng Xiao,Xin Jin,Heng Liu 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.4
The assembly process cannot meet the increasing demands with the conventional method. To obtain an optimal assembly performance, the machined surface should be reconstructed, and further analysis should be conducted to provide a direct guidance for the assembling process. Surface topography can be represented by a sufficient number of points; however, the measurement of dense points would be time-consuming. In this study, the measured points are arranged in a nonuniform manner, and processed by interpolation for the reconstruction of the actual surface and the prediction of the assembly performance. Point clouds processed by 4 interpolation methods were used to verify the proposed method. The sampling strategy and data processing was concluded to be accurate; measurement time was significantly decreased compared to the dense points. It is proposed that the three indexes should be taken into consideration when the method is used to process the measurement data of different machined surfaces.
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Identification and Function Prediction of Novel MicroRNAs in Laoshan Dairy Goats
Ji, Zhibin,Wang, Guizhi,Zhang, Chunlan,Xie, Zhijing,Liu, Zhaohua,Wang, Jianmin Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.3
MicroRNAs are a class of endogenous small RNAs that play important roles in post-transcriptional gene regulation by directing degradation of mRNAs or facilitating repression of target gene translation. In this study, three small RNA cDNA libraries from the mammary gland tissues of Laoshan dairy goats (Capra hircus) were constructed and sequenced, individually. Through Solexa high-throughput sequencing and bioinformatics analysis, we obtained 50 presumptive novel miRNAs candidates, and 55,448 putative target genes were predicted. GO annotations and KEGG pathway analyses showed the majority of target genes were involved in various biological processes and metabolic pathways. Our results discovered more information about the regulation network between miRNAs and mRNAs and paved a foundation for the molecular genetics of mammary gland development in goats.
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Flavonoids in Resina Draconis protect against pulmonary fibrosis via the TGF‑β1/NOTCH1 pathway
Liteng Yang,Xin Liu,Ning Zhang,Gaohui Wu,Lifang Chen,Jingyi Xu,Xi Ren,Xiaoming Jiang,Zhijing Huang 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.2
Background It is known that flavonoids in Resina Draconis (FRD) have anti-inflammatory and analgesic effects, but the function and mechanisms of FRD against pulmonary fibrosis remain unknown. Objective The study aimed to study the effect and mechanism of FRD on pulmonary fibrosis. Methods Pulmonary fibroblasts were isolated and identified. After treatment with transforming growth factor (TGF)-β1 and FRD-containing serum, expressions of TGF-β1, Jagged1, Notch1, alpha-smooth muscle actin, and collagen I were examined using real-time quantitative PCR and Western blot. Besides, the related proteins were verified in rats with bleomycin-induced pulmonary fibrosis. Results We successfully isolated and identified pulmonary fibroblasts and proved that FRD-containing serum inhibits proliferation and downregulates Notch1 expression in TGF-β1-induced fibroblasts. Moreover, our results indicate that FRD might alleviate pulmonary fibrosis via the Jagged1/Notch1 signaling pathways in vivo. Conclusion Flavonoids in Resina Draconis might play a key role in pulmonary fibrosis via critical pathways, especially the TGF-β1 and NOTCH1 signaling pathways.
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