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Zhi-Rong Zhong,Zhi-rong Zhang,Ji Liu,Yong Deng,Hong-wei Zhang,Yao Fu,Qing-guo Song,Qin He 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.1
A novel non-viral gene delivery system, Procationic-Liposome-Protamine-DNA complexes (PLPD) which could further adsorb transferrin on the surface as a targeting ligand to form Tf- PLPD, was prepared and characterized before and after lyophilization. The size distribution of Tf-PLPD was in the range of 240 ± 12 nm and the zeta potential was -24.10 ± 2.5 mV. The transfection efficiencies of PLPD and Tf-PLPD were 12.18 ± 3.8 and 24.26 ± 2.6 mU β-galactosidase/ mg protein respectively. The lyophilization and the presence of serum didn’t affect the tansfectivities of PLPD or Tf-PLPD. Compared to LipofectamineTM 2000 (Invitrogen, U.S.A.), the procationic liposomes had less cytotoxicity to cells. In summary the procationic lipoplex described here, combining the condensing effect of protamine and the targeting capability of Tf, was a perspective non-viral vector for gene delivery system.
Zhang, Zhi-Guo,Li, Gang,Feng, Da-Yun,Zhang, Jian,Zhang, Jing,Qin, Huai-Zhou,Ma, Lian-Ting,Gao, Guo-Dong,Wu, Lin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Several recent studies have showed that the n-myc downstream regulated gene 2 (NDRG2) is a new tumor suppressor gene, and that it plays an important role in tumor suppression in several cancers or cancer cell lines. However, few studies focused on its function in neuroblastoma cells. In the present investigation, we demonstrated that NDRG2 overexpression inhibited their proliferation. Using a cDNA microarray, we found that overexpression of NDRG2 inhibited the expression of cysteine-rich protein 61 (CYR61), a proliferation related gene. From our research, CYR61 may partially hinder NDRG2-mediated inhibition of cell proliferation. Overexpression of NDRG2 resulted in accumulation of cells in the G1 phase, which was accompanied by upregulation of p21 and p27 and downregulation of CDK4 and cyclin D1. Taken together, these data indicate that NDRG2 inhibits the proliferation of neuroblastoma cells partially through suppression of CYR61. Our findings offer novel insights into the physiological roles of NDRG2 in neuroblastoma cell proliferation, and NDRG2 may prove to be effective candidate for the treatment of children with neuroblastoma.
Zhong, Zhi-Rong,Zhang, Zhi-Rong,Liu, Ji,Deng, Yong,Zhang, Hong-Wei,Fu, Yao,Song, Qing-Guo,He, Qin 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.1
A novel non-viral gene delivery system, Procationic-Liposome-Protamine-DNA complexes (PLPD) which could further adsorb transferrin on the surface as a targeting ligand to form Tf-PLPD, was prepared and characterized before and after lyophilization. The size distribution of Tf-PLPD was in the range of $240{\pm}12nm$ and the zeta potential was $-24.10{\pm}2.5mV$. The transfection efficiencies of PLPD and Tf-PLPD were $12.18{\pm}3.8\;and\;24.26{\pm}2.6mU\;{\beta}-galactosidase/mg$ protein respectively. The lyophilization and the presence of serum didn't affect the tansfectivities of PLPD or Tf-PLPD. Compared to $Lipofectamine^{TM}$ 2000 (Invitrogen, U.S.A.), the procationic liposomes had less cytotoxicity to cells. In summary the procationic lipoplex described here, combining the condensing effect of protamine and the targeting capability of Tf, was a perspective non-viral vector for gene delivery system.
Zhi-Jiang Cai,Qin Zhang,Xian-You Song 대한금속·재료학회 2016 ELECTRONIC MATERIALS LETTERS Vol.12 No.6
Polyindole/carbon nanotubes (PIN/CNTs) composite was prepared byan in-situ chemical oxidative polymerization of indole monomer withCNTs using ammonium persulfate as oxidant. The obtained compositematerial was characterized by SEM, TEM, FT-IR, Raman spectroscopy,XPS, XRD and BET surface areas measurements. It was found that theCNTs were incorporated into the PIN matrix and nanoporous structurewas formed. Spectroscopy results showed that interfacial interactionbonds might be formed between the polyindole chains and CNTs duringthe in-situ polymerization. PIN/CNTs composite was evaluated byelectrochemical impedance spectroscopy, cyclic voltammetry andcharge/discharge tests to determine electrode performances in relation tosupercapacitors properties in both aqueous and non-aqueous system. Amaximum specific capacitance and specific volumetric capacitance of555.6 F/g and 222.2 F/cm3 can be achieved at 0.5 A/g in non-aqueoussystem. It also displayed good rate performance and cycling stability. The specific capacitance retention is over 60% at 10 A/g and 91.3%after 5000 cycles at 2 A/g, respectively. These characteristics point to itspromising applications in the electrode material for supercapacitors.
Zhang, Cheng-Dong,Li, Hong-Tao,Liu, Kun,Lin, Zhi-Di,Peng, Qi-Liu,Qin, Xue,He, Min,Wu, Hua,Mo, Zeng-Nan,Yang, Xiao-Li Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18
Background: Despite evidence suggesting roles for caspase-8 (CASP8) -652 6N del and D302H polymorphisms in prostate cancer (PCa), the association of these polymorphisms with PCa risk remains inconclusive. Therefore, a meta-analysis was performed to more precisely estimate the association of CASP8 -652 6N del and D302H polymorphisms with PCa susceptibility. Materials and Methods: A comprehensive literature search was conducted to identify all case-control studies of CASP8 D302H and -652 6N del polymorphisms and PCa risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association and the precision of the estimate, respectively. Results: Nine -625 6N del studies and 4 D302H studies were included. CASP8 -652 6N del and D302H polymorphisms were not significantly associated with PCa risk in the overall analyses. However, in the subgroup analysis stratified by ethnicity, -625 6N del was significantly associated with PCa risk in the East Asian and Indian populations under the recessive model. Furthermore, the subgroup analysis strongly suggested that D302H was associated with lower PCa risk in the Non-Indian population under the dominant model. Conclusions: In our meta-analysis, ethnic-specific differences were evident in the association of CASP8-625 6N del and D302H polymorphisms with PCa risk.
Zhang, Yan,Tang, Jie,Liang, Hai-Dong,Lv, Fa-Qin,Song, Zhi-Gang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4
Background: To investigate the relationship between extracellular matrix parameters and texture of prostatic lesions evaluated by transrectal real-time tissue elastography (TRTE). Methods: 120 patients suspicious for prostate cancer underwent TRTE. Targeted biopsies were carried out after 12-core systematic biopsy. Epithelia were stained with hematoxylin-eosin, and Victoria blue and Ponceau S were used to stain elastic-collagen fibers, and picric acid-sirius red for visualization of collagen type I (Col1) and III (Col3). Smooth muscles were visualized by immunohistochemistry. All image analyses were performed in a blind manner using Image Pro Plus 6.0, and the area ratios of epithelium, elastic fibers, collagen fibers and Col1/Col3 were determined. Results: 42 patients with typical elastograms were included in the final data analysis. Significant differences were detected between the benign and malignant groups in the area ratios of epithelium (P = 0.01), smooth muscles and Col1/Col3 (P = 0.04, P = 0.02, respectively). There were no significant differences in the area ratios of epithelium, smooth muscle and elastic fibers between the stiff and soft lesion groups. The area ratio of Col1 was ($0.05{\pm}0.03$) in the stiff group, and ($0.02{\pm}0.01$) in the soft group (P= 0.00). However, the area ratio of Col3 was ($0.03{\pm}0.02$) in the stiff group, and ($0.05{\pm}0.04$) in the soft group (P = 0.16). Col1/Col3 in the stiff group ($1.99{\pm}1.59$) was greater than in the soft group ($0.71{\pm}0.64$) (P = 0.01). Conclusions: Tissue hardness of prostatic tumors was mainly dependent on the Col1 content, Col1/Col3 being higher in malignant than in benign lesions, so the prostate tissue texture can be used as a target for distinguishing between the two with TRTE.
Zhi Liu,Meiqiao Qin,Yunhua Lu,Sixin Luo,Qinhan Zhang 대한의용생체공학회 2023 Biomedical Engineering Letters (BMEL) Vol.13 No.4
Sleep staging is often applied to assess the quality of sleep and also be used to prevent and monitor psychiatric disorderscaused by sleep. However, it remains a challenge to extract the discriminative features of salient waveforms in sleep EEG andenable the network to effectively classify sleep stages by emphasizing these crucial features, thus achieving higher accuracy. In this study, an end-to-end deep learning model based on DenseNet for automatic sleep staging is designed and constructed. In the framework, two convolutional branches are devised to extract the underlying features (Two-Frequency Feature) at variousfrequencies, which are then fused and input into the DenseNet module to extract salient waveform features. After that,the Coordinate Attention mechanism is employed to enhance the localization of salient waveform features by emphasizingthe position of salient waveforms and the spatial relationship across the entire frequency spectrum. Finally, the obtainedfeatures are accessed to the fully connected for sleep staging. The model was validated with a 20-fold cross-validation procedureon two public available datasets, and the overall accuracy, kappa coefficient, and MF1 score reached 92.9%, 78.7, 0.86and 90.0%, 75.8, 0.80 on Sleep-EDF-20 and Sleep-EDFx, respectively. Experimental results show that the proposed modelachieves competitive performance for sleep staging compared with the reported approaches under the identical conditions.
Ya-Qin Gao,Zhi-Xin Zhang,Ye-Yin Zhao,Fu-Hu Liu 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.60 No.7
Isotopic cross-sections of projectile-like residues produced in 112Sn + 112Sn and 124Sn + 124Sn reactions at an incident beam energy of 1A GeV are studied in the framework of the multi-source thermal model. The multiplicity-like distribution of neutrons in projectile-like isotopes can be successfully expressed by using the Erlang distribution which is the folding result of multi-exponential distributions with the same parameter. The results calculated by using the model are in agreement with the experimental data of Föhr et al. [arXiv:1106.5368vl [nucl-ex]].
Yu-Yue Qin,Zhi-Hong Zhang,Lin Li,Wei Xiong,Jin-Yu Shi,Tian-Rui Zhao,Jian Fan 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.4
The antioxidant potential of pomegranate rind powder extract (PRP), pomegranate juice (PJ), and pomegranate seed powder extract (PSP) was evaluated in raw ground pork meat stored at 4±1oC for 12 days. The pH values decreased from 5.88 to 5.61. The standard plate count in the PRP group was significantly (p<0.05) lower than that in all other groups. Butylated hydroxyl toluene (BHT) and PRP significantly (p<0.05) reduced lipid oxidation compared to PJ and PSP. Samples with antioxidants had significantly (p<0.05) reduced peroxide formation than control group. Antioxidant effectiveness was in the order: BHT>PRP>PJ>PSP>control. Lightness (L* value) was lowered by the addition of PRP, PJ, and PSP. The overall acceptability scores of PRP, PJ, PSP, and BHT treated samples were higher than that of control samples. The results indicated the potential of natural functional ingredients to enhance quality of raw ground pork meat.