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Ming Jia,Zhenhua Wei,Peng Liu,Xiaoli Zhao 대한의학회 2016 Journal of Korean medical science Vol.31 No.6
To investigate the function and regulation mechanism of ATP-binding cassette, subfamily G, member 2 (ABCG2) in retinoblastoma cancer stem cells (RCSCs), a long-term culture of RCSCs from WERI-Rb1 cell line was successfully established based on the high expression level of ABCG2 on the surface of RCSCs. To further explore the molecular mechanism of ABCG2 on RCSCs, a microRNA that specifically targets ABCG2 was predicted. Subsequently, miR-3163 was selected and confirmed as the ABCG2-regulating microRNA. Overexpression of miR-3163 led to a significant decrease in ABCG2 expression. Additionally, ABCG2 loss-of-function induced anti-proliferation and apoptosis-promoting functions in RCSCs, and multidrug resistance to cisplatin, carboplatin, vincristine, doxorubicin, and etoposide was greatly improved in these cells. Our data suggest that miR- 3163 has a significant impact on ABCG2 expression and can influence proliferation, apoptosis, and drug resistance in RCSCs. This work may provide new therapeutic targets for retinoblastoma.
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Min Yuan,Yuanyuan Huang,Zhenhua Jia,Weina Ge,Lan Zhang,Qian Zhao,Shuishan Song,Yali Huang 한국유전학회 2019 Genes & Genomics Vol.41 No.6
Background Trichoderma is one of the most important biocontrol fungi, which could produce mycelia, conidiospores, and chlamydospores three types of propagules under different conditions. Chlamydospores are produced in harsh conditions in various fungi, and may be more resistant to adverse conditions. However, the knowledge associated with the mechanism of chlamydospore formation remained unclear in Trichoderma. Objectives This study is aimed to explore the essential genes and regulatory pathways associated with chlamydospore formation in Trichoderma. Methods The culture condition, survival rate, and biocontrol effects of chlamydospores and conidiospores from Trichoderma. harzianum Tr-92 were determined. Furthermore, the whole transcriptome profiles of T. harzianum Tr-92 under chlamydospore-producing and chlamydospore-nonproducing conditions were performed. Results T. harzianum Tr-92 produced chlamydospores under particular conditions, and chlamydospore-based formulation of T. harzianum Tr-92 exhibited higher biocontrol ability against Botrytis cinerea in cucumber than conidoiospore-based formulation. In the transcriptome analysis, a total of 2,029 differentially expressed genes (DEGs) were identified in T. harzianum Tr-92 under chlamydospore-producing condition, compared to that under chlamydospore-nonproducing condition. GO classification indicated that the DEGs were significantly enriched in 284 terms among biological process, cellular components and molecular function categories. A total of 19 pathways were observed with DEGs by KEGG analysis. Furthermore, fifteen DEGs were verified by quantitative real-time PCR, and the expression profiles were consistent with the transcriptome data. Conclusion The results would provide a basis on the molecular mechanisms underlying Trichoderma sporulation, which would assist the development and application of fungal biocontrol agents.
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Study on Spinnability of PP/PU Blends and Preparation of PP/PU Bi-component Melt Blown Nonwovens
Yanfen Zhou,Liang Jiang,Huiying Jia,Xiaolu Xing,Zhenhua Sun,Shaojuan Chen,Jianwei Ma,Stephen Jerrams 한국섬유공학회 2019 Fibers and polymers Vol.20 No.6
Melt blown polymer blends offers a good way to combine two polymers in the same fiber generating nonwovenswith new and novel properties. In this study, polypropylene (PP) and polyurethane (PU) were blended to prepare PP/PU bicomponentmelt blown nonwovens. The spinnability of PP/PU composites was investigated and PP/PU bi-componentnonwovens with compositions of 95/5, 90/10, 80/20 and 70/30 were prepared by using the melt blowing technique. The meltblown fibers exhibited a ‘sea-island’ structure with PP as the continuous phase and PU as the dispersed phase. When thecontent of PU in the blend was above 40 %, PP/PU melt blown nonwovens could not be produced due to fiber breaking. ForPP/PU (90/10) nonwovens, it was found that the average fiber diameter decreased with increasing die to collector (DCD) andelevated hot air pressure.
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