Analysis on Postoperative Efficacy of Radical Hepatectomy for Patients with Non-HBV/HCV Hepatocellular Carcinoma

Zhang, Zhi-Ming,Zhang, Yu-Mei,Yao, Feng,Yi, Ping,Huang, Shang,Liu, Jian-Yong,Xiang, Bang-De,Yuan, Wei-Ping,Li, Le-Qun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8

Objective: Patients with hepatocellular carcinoma (HCC) in stage Barcelona Clinic Liver Cancer (BCLC)-A were grouped based on whether they were accompanied with hepatitis B virus (HBV) infection or not so as to explore the clinical characteristics and prognostic conditions of HCC patients with non-HBV/hepatitis C virus (HCV). Materials and Methods: Clinical data of 64 stage BCLC-A HCC patients with non-HBV/HCV infection (observation group) who received radical hepatectomy in the Affiliated Cancer Hospital of Guangxi Medical University from January, 2006 to November, 2014 were retrospectively analyzed and compared with those of 409 stage BCLC-A HCC patients with HBV infection (control group) in corresponding period. Results: The postoperative 1-, 3- and 5-year recurrent rates of the observation group were 25%, 38.6% and 48.8%, with postoperative mean and median disease-free survival time being 49.1 months and 62.0 months, respectively. Additionally, the postoperative 1-, 3- and 5-year survival rates of observation group were 90.1%, 72.7% and 62.0%, with the mean and median survival times being 54.4 months and 70.0 months, respectively. Conclusions: The 1-year recurrent rate is the highest in HCC patients with non-HBV/HCV, and almost half of the patients have recurrence within 1 year, after which the recurrent rate decreases along with the time.

Prevalence of Human Papillomavirus 16 in Esophageal Cancer Among the Chinese Population: a Systematic Review and Meta-analysis

Zhang, Shao-Kai,Guo, Lan-Wei,Chen, Qiong,Zhang, Meng,Liu, Shu-Zheng,Quan, Pei-Liang,Lu, Jian-Bang,Sun, Xi-Bin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23

Background and Aim: No firm evidence of HPV infection in esophageal cancer has been established to date. The aim of this meta-analysis was to investigate the prevalence of HPV 16 in esophageal cancer in China, which had a high burden of the disease. Materials and Methods: Studies on HPV infection and esophageal cancer were identified and a random-effects model was used to pool the summary prevalence and corresponding 95% confidence intervals (CIs). Results: A total of 3,429 esophageal cancer cases were evaluated from 26 eligible studies in this meta-analysis. The summary estimate for HPV16 prevalence was 0.381 (95% CI: 0.283, 0.479). The prevalence varied by geographical areas of the study, publication year, HPV detection method and types of specimen. In sensitivity analysis, HPV 16 prevalence ranged from 0.368 (95% CI: 0.276, 0.460) to 0.397 (95% CI: 0.286, 0.508). Conclusions: The results indicate a relatively high level of HPV 16 prevalence in esophageal cancer among Chinese population, although there was variation between different variables. Further studies are needed to elucidate the role of HPV in esophageal carcinogenesis with careful consideration of study design and laboratory detection method, providing more accurate assessment of the HPV status in esophageal cancer.

Preparation and characterization of thermoplastic elastomers (TPEs) based on waste polypropylene and waste ground rubber tire powder

Zhang, Shu Ling,Zhang, Zhen Xiu,Kang, Dong jin,Bang, Dae Suk,Kim, Jin Kuk De Gruyter 2008 E-Polymers Vol.8 No.1

<P><B>Abstract</B></P><P>In this article, the possibility of obtaining the recycled material based on waste polypropylene (WPP) and waste ground rubber tire powder (WGRT) has been studied. It has been proved that partially replacing WPP with PP-g-MA increased the elongation at break of WPP/WGRT blends, whereas decreased the thermal stability. The presence of compatibilizer increased the elongation at break and thermal stability of WPP/WGRT blends, whereas decreased the processing flowability, as revealed by using universal testing machine (UTM), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and capillary rheometer. Moreover, the tendency of the change became more obvious with the content of PP-g-MA and compatibilizer or with the combination of PP-g-MA and compatibilizer. In addition, the improvement of the nonpolar compatibilizer (SEBS) in properties of WPP/WGRT blends was better than that of the polar compatibilizer (SEBS-g-MA).</P>

Network Intrusion Detection Based on Directed Acyclic Graph and Belief Rule Base

Bang-Cheng Zhang,Guan-Yu Hu,Zhi-Jie Zhou,You-Min Zhang,Pei-Li Qiao,Lei-Lei Chang 한국전자통신연구원 2017 ETRI Journal Vol.39 No.4

Intrusion detection is very important for network situation awareness. While a few methods have been proposed to detect network intrusion, they cannot directly and effectively utilize semi-quantitative information consisting of expert knowledge and quantitative data. Hence, this paper proposes a new detection model based on a directed acyclic graph (DAG) and a belief rule base (BRB). In the proposed model, called DAG-BRB, the DAG is employed to construct a multi-layered BRB model that can avoid explosion of combinations of rule number because of a large number of types of intrusion. To obtain the optimal parameters of the DAG-BRB model, an improved constraint covariance matrix adaption evolution strategy (CMA-ES) is developed that can effectively solve the constraint problem in the BRB. A case study was used to test the efficiency of the proposed DAG-BRB. The results showed that compared with other detection models, the DAG-BRB model has a higher detection rate and can be used in real networks.

Microcellular foams of thermoplastic vulcanizates (TPVs) based on waste ground rubber tire powder

Zhang, Zhen Xiu,Zhang, Shu Ling,Lee, Sung Hyo,Kang, Dong Jin,Bang, Dae­Suk,Kim, Jin Kuk Elsevier 2008 Materials letters Vol.62 No.28

<P><B>Abstract</B></P><P>With the increased adoption of thermoplastic vulcanizates (TPVs) in automotive weather seal systems, the foams of TPVs present an important milestone in providing key applications such as trunk and door seals. In this study, microcellular foams of TPV based on waste ground rubber tire powder (WGRT) were investigated. In order to investigate the relationship between processing conditions and structure of TPV foams, we first prepared the thermoplastic vulcanizates of PP-g-MA/WGRT, then the samples were saturated with carbon dioxide and the saturated specimens were expanded during the pressure-quench process. The results indicated that the microcellular structure was dependent on the processing conditions. Cell size increased with saturation temperature, whereas cell density and relative density decreased. Different nucleation processes were produced with saturation pressure.</P>

Aeroengine performance degradation prediction method considering operating conditions

Bang-Cheng Zhang,Shuo Gao,Zhong Zheng,Guanyu Hu 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.9

It is significant to predict the performance degradation of complex electromechanical systems. Among the existing performance degradation prediction models, belief rule base (BRB) is a model that deal with quantitative data and qualitative information with uncertainty. However, when analyzing dynamic systems where observable indicators change frequently over time and working conditions, the traditional belief rule base (BRB) can not adapt to frequent changes in working conditions, such as the prediction of aeroengine performance degradation considering working condition. For the sake of settling this problem, this paper puts forward a new hidden belief rule base (HBRB) prediction method, in which the performance of aeroengines is regarded as hidden behavior, and operating conditions are used as observable indicators of the HBRB model to describe the hidden behavior to solve the problem of performance degradation prediction under different times and operating conditions. The performance degradation prediction case study of turbofan aeroengine simulation experiments proves the advantages of HBRB model, and the results testify the effectiveness and practicability of this method. Furthermore, it is compared with other advanced forecasting methods. The results testify this model can generate better predictions in aspects of accuracy and interpretability.

Human Recombinant Endostatin Combined with Cisplatin Based Doublets in Treating Patients with Advanced NSCLC and Evaluation by CT Perfusion Imaging

Zhang, Feng-Lin,Gao, Er-Yun,Shu, Rong-Bao,Wang, Hui,Zhang, Yan,Sun, Peng,Li, Min,Tang, Wei,Jiang, Bang-Qin,Chen, Shuang-Qi,Cui, Fang-Bo Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

Aims: To study the effectiveness of human recombinant endostatin injection (Endostar(R)) combined with cisplatin doublets in treating advanced non-small cell lung cancer (NSCLC), and to evaluate outcome by CT perfusion imaging. Methods: From April 2011 to September 2014, 76 patients with advanced NSCLC who were treated with platinum-based doublets were divided into group A (36 patients) and group B (40 patients). Endostar(R) 15mg/day was administered 4 days before chemotherapy and combined with chemotherapy from day 5 in group A, and combined with chemotherapy from the first day in Group B. Endostar(R) in the two groups was injected intravenously for 14 days. Results: Treatment effectiveness in the two groups differed with statistical significance (p<0.05). Effectiveness evaluated by CT perfusion imaging, BF, BV, MTT and PS also demonstrated significant differences (all p<0.05). Adverse reactions in the two groups did not significantly vary (p> 0.05). Conclusions: The response rate with Endostar(R) administered 4 days before chemotherapy and combined with chemotherapy from day 5 in group A was better than Endostar(R) combined with chemotherapy from the first day, and CT perfusion imaging could be a reasonable method for evaluation of patient outcomes.

Treatment Efficacy and Prognostic Factors for Huge HCC Based on Barcelona Clinic Liver Cancer Staging

Zhang, Zhi-Ming,Zhang, Yu-Mei,Gao, Sheng,Yuan, Wei-Ping,Zhao, Yin-Nong,Xiang, Bang-De,Wu, Fei-Xiang,Wu, Guo-Bin,Liu, Jian-Yong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

Objective: To explore the most appropriate treatment for patients with hepatocellular cancer (HCC) >10 cm by using the Barcelona Clinic Liver Cancer (BCLC) classification. Materials and Methods: A total of 124 HCC patients undergoing surgery were selected. Disease-free survival (DFS), overall survival (OS) and prognostic factors were respectively assessed. Results: This study showed that the cumulative 1-, 3-, 5-year survival rates were 79.7%, 59.8% and 41.6% in BCLC-A patients, 76.2%, 9.5% and 0% in BCLC-B patients and 44.9%, 0% and 0% in BCLC-C patients, respectively. The 1-, 3-, 5-year DFS rates were 49%, 24.5% and 9.1% in BCLC-A patients, 7.5%, 0% and 0% in BCLC-B patients, respectively. No BCLC-C patients survived 1 year after surgery. Multivariate analysis indicated that hepatitis B surface antigen (HBsAg), vascular invasion, intra-hepatic metastasis, curative resection, tumor rupture and pathologic differentiation were independent prognostic factors. Conclusions: Surgery is effective and safe for patients with HCC >10 cm with sufficient hepatic reserve.

Full Waveguide-band E-plane Power Divider with High Output Power Ratio

Fan Zhang,Qiong-Yue Zhang,Yohan Bang,Bierng-Chearl Ahn 한국정보기술학회 2022 한국정보기술학회논문지 Vol.20 No.2

This paper presents a new E-plane power divider with high output power ratio that operates over the full rectangular waveguide band. The proposed divider consists of an E-plane junction with rounded corners and a smoothly tapered septum. Output ratios of up to 10 are realized by offsetting the septum while output power ratios greater than 10 are achieved by additionally reducing the broad-wall width in the output waveguides with smaller power. Optimum dimensions of the proposed divider are obtained using a commercial electromagnetic-wave simulation tool. A design is given for a power divider in the WR-10 waveguide that has reflection coefficient of less than –20 ㏈ over 75-110 ㎓ and output power ratios up to 100 at 75 ㎓.

Lack of Mutagenicity Potential of Periploca sepium Bge. in Bacterial Reverse Mutation (Ames) Test, Chromosomal Aberration and Micronucleus Test in Mice

Zhang, Mei-Shu,Bang, In-Seok,Park, Cheol-Beom The Korean Society of Environmental Toxicology 2012 환경독성보건학회지 Vol.27 No.-

Objectives: The root barks of Periploca sepium Bge. (P. sepium) has been used in traditional Chinese medicine for healing wounds and treating rheumatoid arthritis. However, toxicity in high-doses was often diagnosed by the presence of many glycosides. The potential mutagenicity of P. sepium was investigated both in vitro and in vivo. Methods: This was examined by the bacterial reverse mutation (Ames) test using Escherichia coli WP2uvrA and Salmonella typhimurium strains, such as TA98, TA100, TA1535, and TA1537. Chromosomal aberrations were investigated using Chinese hamster lung cells, and the micronucleus test using mice. Results: P. sepium did not induce mutagenicity in the bacterial test or chromosomal aberrations in Chinese hamster lung cells, although metabolic activation and micronucleated polychromatic erythrocytes were seen in the mice bone marrow cells. Conclusions: Considering these results, it is suggested that P. sepium does not have mutagenic potential under the conditions examined in each study.