http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lin, Zeng,Lee, In-Seop,Choi, Yoon-Jeong,Noh, In-Sup,Chung, Sung-Min Institute of Physics Pub 2009 Biomedical materials Vol.4 No.1
<P>Different chemical states of titanium oxide films were deposited on commercially pure Ti (CP Ti) by electron-beam evaporation at different oxygen flow rates to examine a possibility of their applications to endovascular stents. The surface morphology, chemical composition and crystal structure of the obtained titanium oxide films were analyzed by FE-SEM, XPS and XRD, respectively. As a function of the deposition parameters employed, the obtained titanium oxide films demonstrated different mixtures of anatase phase, Ti<SUB>2</SUB>O<SUB>3</SUB> and TiO. By the formation of titanium oxide film on the CP Ti plate, the contact angle was decreased and the cellular activity of porcine aortic smooth muscle cells was increased. Post-deposition annealing was also found to be an important factor to achieve advantageous biocompatibility. When haemocompatibility was investigated by observing adhesion of blood platelets from platelet-rich plasma, less platelet adhesion was observed on titanium oxide films. These results indicated that titanium oxide film synthesized by e-beam evaporation could be applicable to coronary stents.</P>
Sensitization of Cervical Carcinoma Cells to Paclitaxel by an IPP5 Active Mutant
Zeng, Qi-Yan,Huang, Yu,Zeng, Lin-Jie,Huang, Min,Huang, Yong-Qi,Zhu, Qi-Fang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19
Paclitaxel is one of the best anticancer agents that has been isolated from plants, but its major disadvantage is its dose-limiting toxicity. In this study, we obtained evidence that the active mutant IPP5 ($8-60hIPP5^m$), the latest member of the inhibitory molecules for protein phosphatase 1, sensitizes human cervix carcinoma cells HeLa more efficiently to the therapeutic effects of paclitaxel. The combination of $8-60hIPP5^m$ with paclitaxel augmented anticancer effects as compared to paclitaxel alone as evidenced by reduced DNA synthesis and increased cytotoxicity in HeLa cells. Furthermore, our results revealed that $8-60hIPP5^m$ enhances paclitaxel-induced G2/M arrest and apoptosis, and augments paclitaxel-induced activation of caspases and release of cytochrome C. Evaluation of signaling pathways indicated that this synergism was in part related to downregulation of NF-${\kappa}B$ activation and serine/threonine kinase Akt pathways. We noted that $8-60hIPP5^m$ downregulated the paclitaxel-induced NF-${\kappa}B$ activation, $I{\kappa}B{\alpha}$ degradation, PI3-K activity and phosphorylation of the serine/threonine kinase Akt, a survival signal which in many instances is regulated by NF-${\kappa}B$. Together, our observations indicate that paclitaxel in combination with $8-60hIPP5^m$ may provide a therapeutic advantage for the treatment of human cervical carcinoma.
Effects of Tissue Factor, PAR-2 and MMP-9 Expression on Human Breast Cancer Cell Line MCF-7 Invasion
Lin, Zeng-Mao,Zhao, Jian-Xin,Duan, Xue-Ning,Zhang, Lan-Bo,Ye, Jing-Ming,Xu, Ling,Liu, Yin-Hua Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Objective: This study aimed to explore the expression of tissue factor (TF), protease activated receptor-2 (PAR-2), and matrix metalloproteinase-9 (MMP-9) in the MCF-7 breast cancer cell line and influence on invasiveness. Methods: Stable MCF-7 cells transfected with TF cDNA and with TF ShRNA were established. TF, PAR-2, and MMP-9 protein expression was analyzed using indirect immunofluorescence and invasiveness was evaluated using a cell invasion test. Effects of an exogenous PAR-2 agonist were also examined. Results: TF protein expression significantly differed between the TF cDNA and TF ShRNA groups. MMP-9 protein expression was significantly correlated with TF protein expression, but PAR-2 protein expression was unaffected. The PAR-2 agonist significantly enhanced MMP-9 expression and slightly increased TF and PAR-2 expression in the TF ShRNA group, but did not significantly affect protein expression in MCF-7 cells transfected with TF cDNA. TF and MMP-9 expression was positively correlated with the invasiveness of tumor cells. Conclusion: TF, PAR-2, and MMP-9 affect invasiveness of MCF-7 cells. TF may increase MMP-9 expression by activating PAR-2.
Flatbands and Emergent Ferromagnetic Ordering in Fe3Sn2 Kagome Lattices
Lin, Zhiyong,Choi, Jin-Ho,Zhang, Qiang,Qin, Wei,Yi, Seho,Wang, Pengdong,Li, Lin,Wang, Yifan,Zhang, Hui,Sun, Zhe,Wei, Laiming,Zhang, Shengbai,Guo, Tengfei,Lu, Qingyou,Cho, Jun-Hyung,Zeng, Changgan,Zhan American Physical Society 2018 Physical Review Letters Vol.121 No.9
Zeng, Qi-Yan,Zeng, Lin-Jie,Huang, Yu,Huang, Yong-Qi,Zhu, Qi-Fang,Liao, Zhi-Hong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.9
Protein phosphatase 1 (PP1) is a major serine/threonine phosphatase that controls gene expression and cell cycle progression. The active mutant IPP5 ($8-60hIPP5^m$), the latest member of the inhibitory molecules for PP1, has been shown to inhibit the growth of human cervix carcinoma cells (HeLa). In order to elucidate the underlying mechanisms, the present study assessed overexpression of $8-60hIPP5^m$ in HeLa cells. Flow cytometric and biochemical analyses showed that overexpression of $8-60hIPP5^m$ induced G2/M-phase arrest, which was accompanied by the upregulation of cyclin B1 and phosphorylation of G2/M-phase proteins ATM, p53, $p21^{cip1/waf1}$ and Cdc2, suggesting that $8-60hIPP5^m$ induces G2/M arrest through activation of the ATM/p53/$p21^{cip1/waf1}$/Cdc2/cyclin B1 pathways. We further showed that overexpression of $8-60hIPP5^m$ led to delayed nuclear translocation of cyclin B1. $8-60hIPP5^m$ also could translocate to the nucleus in G2/M phase and interact with $pp1{\alpha}$ and Cdc2 as demonstrated by co-precipitation assay. Taken together, our data demonstrate a novel role for $8-60hIPP5^m$ in regulation of cell cycle in HeLa cells, possibly contributing to the development of new therapeutic strategies for cervix carcinoma.
Ziwei Lin,Rui Lin,Huaiyu Wu,Linghu Wu,Jieying Zeng,Jinfeng Xu,Fajin Dong 대한초음파의학회 2021 ULTRASONOGRAPHY Vol.40 No.4
Purpose: The aim of this study was to evaluate the value of elastography in the differential diagnosis of benign versus malignant testicular lesions.Methods: The PubMed, Cochrane Library, and Embase databases were searched for relevant studies. The diagnostic accuracy of elastography was evaluated using pooled sensitivity, specificity, likelihood ratio, post-test probability, diagnostic odds ratio, and by summarizing the area under the hierarchical summary receiver operating characteristic (HSROC) curve.Results: Seven studies with 568 lesions were included. The pooled sensitivity and specificity were 87% (95% confidence interval [CI], 81% to 92%) and 81% (95% CI, 65% to 90%), respectively. The pooled estimates of the positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 4.48 (95% CI, 2.37 to 8.47), 0.16 (95% CI, 0.10 to 0.25), and 28.11 (95% CI, 11.39 to 69.36), respectively. The area under the HSROC curve was 90% (95% CI, 88% to 93%).Conclusion: Elastography is useful for assessing the stiffness of testicular lesions and for differentiating benign from malignant lesions. Elastography can be an effective supplement to conventional ultrasonography.
Low Temperature Synthesis of Mesoporous SiC in Dual-Confined Spaces via Magnesiothermic Reduction
Zeng-Rong Wang,Long Liu,Xue Zhang,Jia-Lin Xu,Qiang Sun 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.9
Silicon carbide (SiC), especially mesoporous SiC has been in immense vogue for more than a decade because of its intriguing properties and wide applications. However, it is still challenging to synthesize mesoporous SiC with good structural integrality, large specific surface area and desirable porosity at a low temperature. In this study, we reported a "dual-confined spaces"-assisted synthesis of mesoporous SiC using well-assembled SiO2/carbon composite as precursor via a magnesiothermic reduction process. The well-crystallinity mesoporous SiC presented a mesopore structure with high specific surface area of 267.3 m2 g -1 and large mesopore size of ca. 10 nm can be directly fabricated at a temperature of at least 550 ℃ and the optimum synthesis temperature is 650 ℃. During the synthesis, mesoporous carbon matrix and a pressure-tight stainless steel reactor were served as "dual-confined spaces" to avoid the aggregation of silica and the silicon residue left in the final SiC sample. Furthermore, the as-prepared mesoporous SiC showed prominent performance as catalyst support for the reduction of 4-nitrophenol to 4-aminophenol.
Zeng Wenhui,Yi Jin,Lin Rongfu,Lu Wenlong 한국CDE학회 2022 Journal of computational design and engineering Vol.9 No.2
Blade bearing is the key mechanism of the controllable pitch propellers (CPPs) to adjust the pitch to change the thrust. In the marine environment, wear and deformation of the contact surface of the blade bearing are quite large, which may result in leakage to reduce the service life of CPP. However, most studies on tolerance optimization of blade bearing disregard deformations and wear, and it could result in unreasonable tolerances and impair the CPP’s service life. In this paper, to establish the statistical tolerance–cost–service life optimization model of the blade bearing of the CPP considering the marine environment effects in propellers, a prediction model about the relationship between the thrust and rotation speed of the CPP considering environment conditions of wind, wave, and ocean currents is constructed. Based on this, the wear and deformation are simulated according to the predicted rotation speed in the marine environment. Considering the deformation and wear in the marine environment, a tolerance analysis model of the assembly deviations of the blade bearing is introduced, and the assembly characteristics and functional requirements are established and converted into probability constraints to establish the service-life model based on statistical tolerance analysis and Monte Carlo simulation methods. Afterward, a statistical tolerance–cost–service life optimization model is established and transformed into a single-objective optimization problem through the normalization method and the weighted sum method, and solved by a meta-heuristic algorithm named cuckoo search. Finally, the application of the proposed model is demonstrated through a case involving the blade bearing of a CPP, and the optimized results show that the manufacturing cost of the blade bearing is reduced and its service life is extended.
Lin Xiaoying,Zeng Weipeng,Chen Yilan,Su Ting,Zhong Qinhua,Gong Linzhu,Liu Yamin 한국탄소학회 2022 Carbon Letters Vol.32 No.3
A porous-carbon material UiO-66-C was prepared from metal–organic frameworks UiO-66 by carbonization in inert gas atmosphere. Physicochemical properties of UiO-66-C materials were well characterized by Powder X-ray diffraction (PXRD), Scanning electron microscope (SEM), Fourier-transform infrared spectroscopy (FT-IR), Raman spectrometer, N2 adsorption/desorption isotherms (BET), and the adsorption properties of the products were studied UiO-66-C has a high specific surface area up to 1974.17 m2/g. Besides, the adsorption capacity of tetracycline could reach 678.19 mg/g, the adsorption processes agreed well with the pseudo-second-order kinetic model and Langmuir isotherm model.