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        Effect of calcination and reaction conditions on the catalytic performance of Co–Ni/Al2O3 catalyst for CO hydrogenation

        Akbar Zare,Mehdi Shiva,Ahad Zare,Ali Akbar Mirzaei 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.6

        The Co–Ni/Al2O3 catalysts prepared using impregnation procedure, were used for the Fischer–Tropsch synthesis. The effect of calcination conditions of the catalyst as well as reactor situation was studied. It was found that the catalyst calcined at 550 8C for 6 h in air atmosphere has shown the best catalytic performance for CO hydrogenation. The best operational conditions were obtained as following:T = 350 8C, P = 1 atm and H2/CO = 2/1.

      • Novel aspects of elastic flapping wing: Analytical solution for inertial forcing

        Zare, Hadi,Pourtakdoust, Seid H.,Bighashdel, Ariyan Techno-Press 2018 Advances in aircraft and spacecraft science Vol.5 No.3

        The structural dynamics (SD) behavior of Elastic Flapping Wings (EFWs) is investigated analytically as a novel approach in EFWs analysis. In this regard an analytical SD solution of EFW undergoing a prescribed rigid body motion is initially derived, where the governing equations are expressed in modal space. The inertial forces are also analytically computed utilizing the actuator induced acceleration effects on the wing structure, while due to importance of analytical solution the linearity assumption is also considered. The formulated initial-value problem is solved analytically to study the EFW structural responses, where the effect of structure-actuator frequency ratio, structure-flapping frequency ratio as well as the structure damping ratio on the EFW pick amplitude is analyzed. A case study is also simulated in which the wing is modeled as an elastic beam with shell elements undergoing a prescribed sinusoidal motion. The corresponding EFW transient and steady response in on-off servo behavior is investigated. This study provides a conceptual understanding for the overall EFW SD behavior in the presence of inertial forces plus the servo dynamics effects. In addition to the substantial analytical results, the study paves a new mathematical way to better understanding the complex role of SD in dynamic EFWs behavior. Specifically, similar mathematical formulations can be carried out to investigate the effect of aerodynamics and/or gravity.

      • Vibration modelling and structural modification of combine harvester thresher using operational modal analysis and finite element method

        Zare, Hamed Ghafarzadeh,Maleki, Ali,Rahaghi, Mohsen Irani,Lashgari, Majid Techno-Press 2019 Structural monitoring and maintenance Vol.6 No.1

        In present study, Operational Modal Analysis (OMA) was employed to carry out the dynamic and vibration analysis of the threshing unit of the combine harvester thresher as a mechanical component. The main study is to find the causes of vibration and to decrease it to enhance the lifetime and efficiency of the threshing unit. By utilizing OMA, structural modal parameters such as mode shapes, natural frequencies, and damping ratio was calculated. The combine harvester was excited by engine to vibrate different parts and accelerometer sensor collected acceleration signals at different speeds, and OMA was utilized by nonparametric and frequency analysis methods to obtain modal parameters while vibrating in real working conditions. Afterwards, finite element model was designed from the thresher and updated using the data obtained from the modal analysis. Using the conducted analyses, it was specified that proximity of the thresher pass frequency to one of the natural frequencies (16.64 Hz) was the most important effect of vibration in the thresher. Modification process of the structure was carried out by increasing mass required for changing the natural frequency location of the first mode to 12.4 Hz in order to reduce resonance and vibration of the thresher.

      • Comparison between Parametric and Semi-parametric Cox Models in Modeling Transition Rates of a Multi-state Model: Application in Patients with Gastric Cancer Undergoing Surgery at the Iran Cancer Institute

        Zare, Ali,Mahmoodi, Mahmood,Mohammad, Kazem,Zeraati, Hojjat,Hosseini, Mostafa,Naieni, Kourosh Holakouie Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

        Background: Research on cancers with a high rate of mortality such as those occurring in the stomach requires using models which can provide a closer examination of disease processes and provide researchers with more accurate data. Various models have been designed based on this issue and the present study aimed at evaluating such models. Materials and Methods: Data from 330 patients with gastric cancer undergoing surgery at Iran Cancer Institute from 1995 to 1999 were analyzed. Cox-Snell Residuals and Akaike Information Criterion were used to compare parametric and semi-parametric Cox models in modeling transition rates among different states of a multi-state model. R 2.15.1 software was used for all data analyses. Results: Analysis of Cox-Snell Residuals and Akaike Information Criterion for all probable transitions among different states revealed that parametric models represented a better fitness. Log-logistic, Gompertz and Log-normal models were good choices for modeling transition rate for relapse hazard (state $1{\rightarrow}state$ 2), death hazard without a relapse (state $1{\rightarrow}state$ 3) and death hazard with a relapse (state $2{\rightarrow}state$ 3), respectively. Conclusions: Although the semi-parametric Cox model is often used by most cancer researchers in modeling transition rates of multistate models, parametric models in similar situations- as they do not need proportional hazards assumption and consider a specific statistical distribution for time to occurrence of next state in case this assumption is not made - are more credible alternatives.

      • Assessing Markov and Time Homogeneity Assumptions in Multi-state Models: Application in Patients with Gastric Cancer Undergoing Surgery in the Iran Cancer Institute

        Zare, Ali,Mahmoodi, Mahmood,Mohammad, Kazem,Zeraati, Hojjat,Hosseini, Mostafa,Naieni, Kourosh Holakouie Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

        Background: Multi-state models are appropriate for cancer studies such as gastrectomy which have high mortality statistics. These models can be used to better describe the natural disease process. But reaching that goal requires making assumptions like Markov and homogeneity with time. The present study aims to investigate these hypotheses. Materials and Methods: Data from 330 patients with gastric cancer undergoing surgery at Iran Cancer Institute from 1995 to 1999 were analyzed. To assess Markov assumption and time homogeneity in modeling transition rates among states of multi-state model, Cox-Snell residuals, Akaikie information criteria and Schoenfeld residuals were used, respectively. Results: The assessment of Markov assumption based on Cox-Snell residuals and Akaikie information criterion showed that Markov assumption was not held just for transition rate of relapse (state 1 ${\rightarrow}$ state 2) and for other transition rates - death hazard without relapse (state 1 ${\rightarrow}$ state 3) and death hazard with relapse (state 2 ${\rightarrow}$ state 3) - this assumption could also be made. Moreover, the assessment of time homogeneity assumption based on Schoenfeld residuals revealed that this assumption - regarding the general test and each of the variables in the model- was held just for relapse (state 1 ${\rightarrow}$ state 2) and death hazard with a relapse (state 2 ${\rightarrow}$ state 3). Conclusions: Most researchers take account of assumptions such as Markov and time homogeneity in modeling transition rates. These assumptions can make the multi-state model simpler but if these assumptions are not made, they will lead to incorrect inferences and improper fitting.

      • Modeling of Breast Cancer Prognostic Factors Using a Parametric Log-Logistic Model in Fars Province, Southern Iran

        Zare, Najaf,Doostfatemeh, Marzieh,Rezaianzadeh, Abass Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

        In general, breast cancer is the most common malignancy among women in developed as well as some developing countries, often being the second leading cause of cancer mortality after lung cancer. Using a parametric log-logistic model to consider the effects of prognostic factors, the present study focused on the 5-year survival of women with the diagnosis of breast cancer in Southern Iran. A total of 1,148 women who were diagnosed with primary invasive breast cancer from January 2001 to January 2005 were included and divided into three prognosis groups: poor, medium, and good. The survival times as well as the hazard rates of the three different groups were compared. The log-logistic model was employed as the best parametric model which could explain survival times. The hazard rates of the poor and the medium prognosis groups were respectively 13 and 3 times greater than in the good prognosis group. Also, the difference between the overall survival rates of the poor and the medium prognosis groups was highly significant in comparison to the good prognosis group. Use of the parametric log-logistic model - also a proportional odds model - allowed assessment of the natural process of the disease based on hazard and identification of trends.

      • Assessing Misdiagnosis of Relapse in Patients with Gastric Cancer in Iran Cancer Institute Based on a Hidden Markov Multi-state Model

        Zare, Ali,Mahmoodi, Mahmood,Mohammad, Kazem,Zeraati, Hojjat,Hosseini, Mostafa,Naieni, Kourosh Holakouie Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.9

        Background: Accurate assessment of disease progression requires proper understanding of natural disease process which is often hidden and unobservable. For this purpose, disease status should be clearly detected. But in most diseases it is not possible to detect such status. This study, therefore, aims to present a model which both investigates the unobservable disease process and considers the error probability in diagnosis of disease states. Materials and Methods: Data from 330 patients with gastric cancer undergoing surgery at the Iran Cancer Institute from 1995 to 1999 were analyzed. Moreover, to estimate and assess the effect of demographic, diagnostic and clinical factors as well as medical and post-surgical variables on transition rates and the probability of misdiagnosis of relapse, a hidden Markov multi-state model was employed. Results: Classification errors of patients in alive state without a relapse ($e_{21}$) and with a relapse ($e_{12}$) were 0.22 (95% CI: 0.04-0.63) and 0.02 (95% CI: 0.00-0.09), respectively. Only variables of age and number of renewed treatments affected misdiagnosis of relapse. In addition, patient age and distant metastasis were among factors affecting the occurrence of relapse (state1${\rightarrow}$state2) while the number of renewed treatments and the type and extent of surgery had a significant effect on death hazard without relapse (state2${\rightarrow}$state3)and death hazard with relapse (state2${\rightarrow}$state3). Conclusions: A hidden Markov multi-state model provides the possibility of estimating classification error between different states of disease. Moreover, based on this model, factors affecting the probability of this error can be identified and researchers can be helped with understanding the mechanisms of classification error.

      • Survival Analysis of Patients with Gastric Cancer Undergoing Surgery at the Iran Cancer Institute: A Method Based on Multi-State Models

        Zare, Ali,Mahmoodi, Mahmood,Mohammad, Kazem,Zeraati, Hojjat,Hosseini, Mostafa,Naieni, Kourosh Holakouie Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

        Background: Gastric cancer is one of the most common causes of cancer deaths all over the world and the most important reason for its high rate of death is its belated diagnosis at advanced stages of the disease. Events occur in patients which are regarded not only as themselves factors affecting patients' survival but also which can be affected by other factors. This study was designed and implemented aiming to identify these events and to investigate factors affecting their occurrence. Materials and Methods: Data from 330 patients with gastric cancer undergoing surgery at the Iran Cancer Institute from 1995-1999 were analyzed. The survival time of these patients was determined after surgery and the effects of various factors including demographic, diagnostic and clinical as well as medical, and post-surgical varuiables on the occurrence of death hazard without relapse, hazard of relapse, and death hazard with a relapse were assessed. Results: The median survival time for these patients was 16.3 months and the 5-year survival rate was 21.6%. Based on the results of multi-state model, age and distant metastases affected relapse whereas disease stage, type and extent of surgery, lymph nodes metastases, and number of renewed treatments affected death hazard without relapse. Moreover, age, type and extent of surgery, number of renewed treatments, and liver metastases were identified as factors affecting death hazard in patients with relapse. Conclusions: Most cancer studies pay heed to factors which have effect on death occurrence, but some events occur which should be taken into consideration to better describe the natural process of the disease and provide researchers with more accurate data.

      • Factors Affecting Survival in Patients with Colorectal Cancer in Shiraz, Iran

        Zare-Bandamiri, Mohammad,Khanjani, Narges,Jahani, Yunes,Mohammadianpanah, Mohammad Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.1

        Background: Colorectal cancer (CRC) is the third most common cancer in the world, and the fourth in Iran in both genders. The aim of this study was to find predictive factors for CRC survival. Materials and Methods: Medical records of 570 patients referred to the radiotherapy oncology department of Shiraz Namazi hospital from 2005 to 2010 were retrospectively analysed. Data were collected by reviewing medical records, and by telephone interviews with patients. Survival analysis was performed using the Cox's regression model with survival probability estimated with Kaplan-Meier curve. The log-rank test was used to compare survival between strata. Data was analyzed with Stata 12. Results: The five-year survival rate and the mean survival time after cancer diagnosis were 58.5% and $67{\pm}4months$. On multivariate analysis, age of diagnosis, disease stage and primary tumor site, lymphovascular invasion and type of treatment (in colon cancer) were significant factors for survival. Conclusions: Age of diagnosis and type of treatment (adjuvant therapy in patients with colon cancer) were two modifiable factors related to survival of CRC patients. Therefore earlier diagnosis might help increase survival.

      • Efficiency of stress transfer between polymer matrix and nanoplatelets in clay/polymer nanocomposites

        Zare, Yasser,Fasihi, Mohammad,Rhee, Kyong Yop Elsevier 2017 Applied clay science Vol.143 No.-

        <P><B>Abstract</B></P> <P>The Hui-Shia model, which considers the complete stress transfer between polymer matrix and particles (perfect interfacial adhesion), overpredicts the Young's modulus of clay/polymer nanocomposites (CPN). In this work, the effective aspect ratio and volume fraction of nanoclay are expressed assuming the imperfect load transfer, the minimum length of platelets required for efficient stress transfer (<I>L</I> <SUB> <I>c</I> </SUB>) and the interfacial shear strength (<I>τ</I>). Additionally, “<I>I</I>” parameter as the level of stress transfer in CPN is defined and determined using the effective parameters. The large nanoclay platelets with low “<I>L</I> <SUB> <I>c</I> </SUB>” give a high level of “<I>I</I>”. Also, high “<I>L</I> <SUB> <I>c</I> </SUB>” and slight “<I>τ</I>” observe the poor levels of effective parameters and Young's modulus of CPN. The “<I>I</I>” values are calculated for some samples which indicate the different levels of stress transfer in CPN. It is possible to analyze the levels of interfacial properties and stress transfer in CPN using the developed model.</P> <P><B>Highlight</B></P> <P> <UL> <LI> The Hui-Shia model is developed for Young's modulus of clay/polymer nanocomposites. </LI> <LI> The effective aspect ratio and volume fraction of nanoclay are expressed. </LI> <LI> The critical length of platelets and interfacial shear strength are assumed. </LI> <LI> “<I>I</I>” parameter is defined as the level of stress transfer and determined. </LI> </UL> </P>

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