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RISS 인기검색어
- 검색키워드
- 저자 : Yuzhen Han (검색결과 3 건)
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Failure of circular tunnel in saturated soil subjected to internal blast loading
Han, Yuzhen,Liu, Huabei Techno-Press 2016 Geomechanics & engineering Vol.11 No.3
Explosions inside transportation tunnels might result in failure of tunnel structures. This study investigated the failure mechanisms of circular cast-iron tunnels in saturated soil subjected to medium internal blast loading. This issue is crucial to tunnel safety as many transportation tunnels run through saturated soils. At the same time blast loading on saturated soils may induce residual excess pore pressure, which may result in soil liquefaction. A series of numerical simulations were carried out using Finite Element program LS-DYNA. The effect of soil liquefaction was simulated by the Federal Highway soil model. It was found that the failure modes of tunnel lining were differed with different levels of blast loading. The damage and failure of the tunnel lining was progressive in nature and they occurred mainly during lining vibration when the main event of blast loading was over. Soil liquefaction may lead to more severe failure of tunnel lining. Soil deformation and soil liquefaction were determined by the coupling effects of lining damage, lining vibration, and blast loading. The damage of tunnel lining was a result of internal blast loading as well as dynamic interaction between tunnel lining and saturated soil, and stress concentration induced by a ventilation shaft connected to the tunnel might result in more severe lining damage.
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Bangyue Zhang,Yuzhen Han,Jianheng Jia,Min Yang,Chunxia Yan 한국분자세포생물학회 2012 Molecules and cells Vol.34 No.4
Leaf senescence is the final stage of leaf life history, and it can be regulated by multiple internal and external cues. La-related proteins (LARPs), which contain a well-con-served La motif (LAM) domain and normally a canonical RNA recognition motif (RRM) or noncanonical RRM-like motif, are widely present in eukaryotes. Six LARP genes (LARP1a-1c and LARP6a-6c) are present in Arabidopsis, but their biological functions have not been studied previously. In this study, we investigated the biological roles of LARP1c from the LARP1 family. Constitutive or inducible overexpression of LARP1c caused premature leaf senescence. Expression levels of several senes-cence-asso-ciated genes and defense-related genes were elevated upon overexpression of LARP1c. The LARP1c null mutant 1c-1 impaired ABA-, SA-, and MeJA-induced leaf senescence in detached leaves. Gene expression profiles of LARP1c showed age-dependent expression in rosette leaves. Taken together, our results suggest LARP1c is involved in regulation of leaf senescence.
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Jiajia Zhang,Feize Li,Yuzhen Yin,Ning Liu,Mengqin Zhu,Han Zhang,Weihao Liu,Mengdie Yang,Shanshan Qin,Xin Fan,Yuanyou Yang,Kun Zhang,Fei Yu 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4
Background: Astatine-211 is an α-emitter with high-energy α-ray and high cytotoxicity for cancer cells. However, the targeted alpha therapy (TAT) also suffers from insufficient systematic immune activation, resulting in tumor metastasis and relapse. Combined immune checkpoint blockade (ICB) with chemodynamic therapy (CDT) could boost antitumor immunity, which may magnify the immune responses of TAT. This study aims to discourage tumor metastasis and relapse by tri-model TAT-CDT-ICB strategy. Methods: We successfully designed Mn-based radioimmunotherapy promoters (211At-ATE-MnO2-BSA), which are consisting of 211At, MnO2 and bovine serum albumin (BSA). The efficacy of 211At-ATE-MnO2-BSA was studied as monotherapy or in combination with anti-PD-L1 in both metastatic and relapse models. The immune effects of radioimmunotherapy promoters on cytotoxic T lymphocytes and dendritic cells (DCs) were analyzed by flow cytometry. Enzymelinked immunosorbent assay and immunofluorescence were used to explore the underlying mechanism. Results: Such radioimmunotherapy promoters could not only enhance the therapeutic outcomes of TAT and CDT, but also induce robust anti-cancer immune activity by activating dendritic cells. More intriguingly, 211At-ATE-MnO2-BSA could effectively suppress the growths of primary tumors and distant tumors when combined with immune checkpoint inhibitors. Conclusions: The tri-model TAT-CDT-ICB strategy provides a long-term immunological memory, which can protect against tumor rechallenge after eliminating original tumors. Therefore, this work presents a novel approach for TATCDT-ICB tri-modal cancer therapy with repressed metastasis and relapse in clinics.
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