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Yusuke Azuma,Shuichi Onami 대한의용생체공학회 2014 Biomedical Engineering Letters (BMEL) Vol.4 No.4
In recent years, development of image processing methodshas rapidly progressed to automatically identify spatiotemporaldynamics of embryonic cells in Caenorhabditis elegans. Themethods allow quantitative and high-throughput analysis formolecular dynamics during embryogenesis. In turn, theanalyzed dynamics can be merged onto a reference embryo,providing an integrated view of embryogenesis. This integrationis enabled by invariant embryogenesis of C. elegans, whichis the most unique advantage offered by this organism. Therefore, the key point in the development of the methodsis how to take advantage of this feature. In this article, wereview a series of development of such methods and theirapplications. First, we describe basic image processing methodsthat are the basis for development of cell identificationmethods. Next, we describe methods that have succeeded toidentify cells in images and their performance. Finally, wereview studies that have employed cell identificationmethods to analyze the variability of cellular dynamics, cellcellcontacts and cell fate determination. Together withadvances in imaging technologies to measure moleculardynamics and computational methods to identify suchdynamics with high accuracy, the unique system of invariantembryogenesis in C. elegans will be invaluable to studydevelopmental mechanisms. Therefore, it is important tounderstand the ever developing technologies and theirresults.
( Hirokatu Azuma ),( Yusuke Kobayashi ),( Hiroaki Ishiguro ),( Hideo Kobayashi ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: In late years, it`s been revealed that orthostatic hypotension (OH) is a risk factor associated with the onset of cardiovascular disease. It is considered that autonomic nervous dysfunction and arteriosclerosis are the important cause of OH. However, there are few reports of the association between atherosclerotic disease such as kidney disease and OH. Therefore, we evaluated the association between renal function and OH in non-diabetic patients. Methods: We studied 320 non-diabetic patients having arteriosclerosis risk factors such as hypertension and dyslipidemia. CAVI was measured as an index of arterial stiffness. We performed sit-to-stand orthostatic stress test to evaluate the association between blood pressure change, eGFR, and heart rate variability. Results: A signifi cant positive correlation was found between eGFR and orthostatic blood change both in systolic and diastolic blood pressure. There was a negative correlation between CAVI and eGFR. LF (low frequency) at the rest state and eGFR tended to have a positive correlation, and a signifi cant positive correlation was found between LF at the standing state and eGFR. There were no signifi cant correlation between eGFR and orthostatic change in HF (high frequency) and LF/HF. In the multiple regression analysis, orthostatic change in systolic blood pressure had a significant correlation with gender, BMI and eGFR. Conclusions: Our results indicate that orthostatic blood pressure decline is associated with decreased renal function in non-diabetic patients. It was suggested that decreased renal function is an important risk factor of OH independent of arterial stiffness and autonomic nervous function.
Establishment of a canine mammary gland tumor cell line and characterization of its miRNA expression
Tomohiro Osaki,Yuji Sunden,Akihiko Sugiyama,Kazuo Azuma,Yusuke Murahata,Takeshi Tsuka,Norihiko Itoh,Tomohiro Imagawa,Yoshiharu Okamoto 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.3
Canine mammary gland tumors (CMGTs), which are the most common neoplasms in sexually intact female dogs, have been suggested as a model for studying human breast cancer because of several similarities, including relative age of onset, risk factors, incidence, histological and molecular features, biological behavior, metastatic pattern, and responses to therapy. In the present study, we established a new cell line, the SNP cell line, from a CMGT. A tumor formed in each NOD.CB17-Prkdcscid/J mouse at the site of subcutaneous SNP cell injection. SNP cells are characterized by proliferation in a tubulopapillary pattern and are vimentin positive. Moreover, we examined miRNA expression in the cultured cells and found that the expression values of miRNA-143 and miRNA-138a showed the greatest increase and decrease, respectively, of all miRNAs observed, indicating that these miRNAs might play a significant role in the malignancy of SNP cells. Overall, the results of this study indicate that SNP cells might serve as a model for future genetic analysis and clinical treatments of human breast tumors.
Unilateral rostral mandibulectomy for gingival vascular hamartoma in two calves
Takeshi Tsuka,Yoshiharu Okamoto,Naoki Yamamoto,Keiji Hayashi,Takehito Morita,Yuji Sunden,Yusuke Murahata,Kazuo Azuma,Tomohiro Osaki,Norihiko Ito,Tomohiro Imagawa 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.4
A 2-month-old female Holstein calf and a 5-month-old female Japanese black calf presented with gingival vascular hamartoma located in the interdental space between the second and third mandibular incisors in the right and left mandibles, respectively. On radiographic or computed tomographic images, osteolytic changes appeared within the mandibular bones adjacent to the masses. The masses were removed along with affected mandibular bone by using unilateral rostral mandibulectomy. After surgery, both cases exhibited a normal appetite and grew normally, with no cosmetic changes or recurrences. Unilateral rostral mandibulectomy can be applied for invasive gingival vascular hamartomas associated with osteolytic changes.