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      • Large-scale Landslides in Diexi Region of Minjiang River, Sichuan Province, China

        ( Yunsheng Wang ),( Bo Zhao ),( Xun Zhao ),( Qianqian Feng ),( Fengshuang Guo ),( Yue Luo ),( Jiangwei Liu ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2

        The field survey regarding large-scale landslide (Scale) of whole Minjiang River shows that Diexi region, located in upper reach of Minjiang River, is an obvious large-scale landslide concentration area. There are 21 large-scale landslides in Diexi region, and 70% landslides belong to super large-scale landslides (Scale), as shown in Figure 1. All these landslides both blocked rivers and some barrier lakes still exist. Based on field investigations, the failure mechanism and geological environment are discussed in this study. For failure mechanism, three fracture planes cut the rock mass into separation; the stepped fractures forms slip surfaces; finally, these unstable rock mass slide. For geological environment, Diexi region is in west boundary of Minshan block, and in the N-S seismic belt and the Jiaochang arc tectonic belt, two active fractures (Songpinggou fracture and Minjiang fracture) confluence at Diexi region; all these make Diexi region be a Knick point of Minjiang River, a compression and torsion zone and a high stress concentration zone. Intensive uplift and quick incision (1.88 mm/yr.) since the middle Pleistocene formed a gorge with sharp slopes and strong lateral uploading. For failure cause, the intensive tectonic activities make the rock mass produce many fractures, numerous strong earthquakes weaken the rock mass integrity further; finally, the strong earthquake triggered them.

      • Fused Heptacyclic-Based Acceptor-Donor-Acceptor Small Molecules: N-Substitution toward High-Performance Solution-Processable Field-Effect Transistors

        Zhang, Guobing,Zhao, Yao,Kang, Boseok,Park, Sangsik,Ruan, Jiufu,Lu, Hongbo,Qiu, Longzhen,Ding, Yunsheng,Cho, Kilwon American Chemical Society 2019 Chemistry of materials Vol.31 No.6

        <P>Although various donor-acceptor (D-A) small molecules with high power conversion efficiency have been reported, D-A small molecules with high field-effect mobility are still rare. In this work, two new A-D-A small molecules with a rigid indacenodithieno[3,2-<I>b</I>]thiophene (<B>IDTT</B>) moiety as the central core and both ends capped with strong electron-withdrawing indole-2,3-dione (<B>IDD</B>) and N-substituted pyrrolo[2,3-<I>b</I>]pyridine-2,3-dione (<B>IDD-N</B>) were synthesized and characterized for applications in solution-processable organic field-effect transistors (OFETs). A N atom was introduced to the <B>IDD</B> units to enhance the planarity and structural ordering by noncovalent interactions, leading to a dramatic effect on the small molecule. The unsubstituted small molecule (<B>IDTT-IDD</B>) did not show any field-effect performance, whereas an encouraging hole mobility of 7.7 cm<SUP>2</SUP> V<SUP>-1</SUP> s<SUP>-1</SUP> with an average mobility of 6.1 cm<SUP>2</SUP> V<SUP>-1</SUP> s<SUP>-1</SUP> was obtained for solution-processable OFETs based on the N-substituted one (<B>IDTT-IDD-N</B>). This work provided a simple and effective molecular strategy for the design of D-A small molecules for high-performance solution-processable OFETs.</P> [FIG OMISSION]</BR>

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        Effect of Different Blade Numbers on the Radial Force of Pump as Turbine in Transient Process

        FengXia Shi,DeDong Ma,WanYong Zhao,HuTing Peng,YunSheng Liang 한국유체기계학회 2021 International journal of fluid machinery and syste Vol.14 No.2

        In order to analyze the influence of the number of blades on the radial force characteristics of pump as turbine during the variable flow rate transition process, six impellers with different number of blades are designed. On the basis of verifying the correctness of the numerical calculation method by the external characteristic experiment, the steady and unsteady numerical simulation of each scheme is carried out by ANSYS-CFX software, the radial force characteristics on impellers with different schemes are compared and analyzed. The results show that during the transition process of variable flow rate, the radial force vector and its fluctuation range on the impeller gradually decreases with the increase of the number of blades. The radial resultant force obviously increases with the increase of time in the transition to large flow rate, and obviously decreases with the increase of time in the transition to small flow rate. The dominant frequency of the radial force is equal to leaf frequency, and the pulsation amplitude of the radial force of Z9 is the minimum in both transition processes. In the transition process of variable flow rate, when the number of blades is Z9, the efficiency is the highest, the radial force on the impeller is the minimum, and the pulsation amplitude of the radial force is also the smallest, so for this pump as turbine, the value of blade number equals 9 is the optimal.

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        A New Practical System for Evaluating the Pharmacological Properties of Uricase as a Potential Drug for Hyperuricemia

        Juan Feng,Xiang Li,Xiaolan Yang,Chun Zhang,Yonghua Yuan,Jun Pu,Yunsheng Zhao,Yanling Xie,Huidong Yuan,Youquan Bu,Fei Liao 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.11

        The use of uricase-deficient mammals to screen formulations of engineered uricases as potential drugs for hyperuricemia involves heavy costs and presents a technical bottleneck. Herein, a new practical system was investigated to evaluate the pharmacological significance of a bacterial uricase based on its ability to eliminate uric acid in plasma in vitro, its pharmacokinetics in vivo in healthy rats, and the modeled pharmacodynamics in vivo. This uricase, before and after modification with the monomethyl ether of poly(ethylene glycol)-5000, effectively eliminated uric acid in vitro in rabbit plasma, but its action was susceptible to xanthine inhibition. After intravenous injection of the modified uricase without purification, a bi-exponential model fit well to uricase activities in vivo in the plasma of healthy rats; the half-life of the modified uricase was estimated without interference from the unmodified uricase leftover in the sample and was nearly 100-fold longer than that of the unmodified uricase. Using a model of the elimination of uric acid in vivo taking into account of uricase pharmacokinetics and xanthine inhibition, modeled pharmacodynamics supported that the half-life of uricase and its susceptibility to xanthine are crucial for the pharmacological significance of uricase. Hence,this practical system is desirable for doing preliminary screening of formulations of engineered uricases as potential drugs for hyperuricemia.

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