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      • KCI등재

        Performance of Q-learning based resource allocation for D2D communications in heterogeneous networks

        Lee Shu-Hung,Shi Xiao-Pei,Tan Tan-Hsu,Lee Yu-Lin,Huang Yung-Fa 한국통신학회 2023 ICT Express Vol.9 No.6

        This study investigates energy efficiency issues of device-to-device (D2D) communications in heterogeneous networks. To minimize the total transmitted power, an approach based on Q-learning together with adaptive ɛ -greedy is proposed to optimize the connection of user equipment (UE) with base station (BS) or access point (AP). The proposed adaptive ɛ -greedy can conduct the adequate exploration and exploitation operations for effective optimization. Simulation results indicate that in the single-cell scenario, the proposed method can attain performance close to the best solution.

      • KCI등재

        Cilostazol ameliorates diabetic nephropathy by inhibiting highglucose-induced apoptosis

        Chien-Wen Chian,Yung-Shu Lee,Yi-Ju Lee,Ya-Hui Chen,Chi-Ping Wang,Wen-Chin Lee,Huei-Jane Lee 대한생리학회-대한약리학회 2020 The Korean Journal of Physiology & Pharmacology Vol.24 No.5

        Diabetic nephropathy (DN) is a hyperglycemia-induced progressive development of renal insufficiency. Excessive glucose can increase mitochondrial reactive oxygen species (ROS) and induce cell damage, causing mitochondrial dysfunction. Our previous study indicated that cilostazol (CTZ) can reduce ROS levels and decelerate DN progression in streptozotocin (STZ)-induced type 1 diabetes. This study investigated the potential mechanisms of CTZ in rats with DN and in high glucose-treated mesangial cells. Male Sprague-Dawley rats were fed 5 mg/kg/day of CTZ after developing STZ-induced diabetes mellitus. Electron microscopy revealed that CTZ reduced the thickness of the glomerular basement membrane and improved mitochondrial morphology in mesangial cells of diabetic kidney. CTZ treatment reduced excessive kidney mitochondrial DNA copy numbers induced by hyperglycemia and interacted with the intrinsic pathway for regulating cell apoptosis as an antiapoptotic mechanism. In high-glucose-treated mesangial cells, CTZ reduced ROS production, altered the apoptotic status, and down-regulated transforming growth factor beta (TGF-β) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB). Base on the results of our previous and current studies, CTZ deceleration of hyperglycemia-induced DN is attributable to ROS reduction and thereby maintenance of the mitochondrial function and reduction in TGF-β and NF-κB levels.

      • KCI등재

        Conditions and Patterns of Intimate Partner Violence among Taiwanese Women

        Fang-Hsin Lee,Yung-Mei Yang,Hsiu-Hung Wang,Joh-Jong Huang,Shu-Chen Chang 한국간호과학회 2015 Asian Nursing Research Vol.9 No.2

        Purpose: Intimate partner violence (IPV) is a serious public health issue among women. IPV victims usually seek help from hospitals, and emergency nurses are the frontline staff with whom the victims come into contact first. This study examined the conditions and patterns of IPV in southern Taiwan. Methods: From designated hospitals in Kaohsiung under the Department of Health Injury Assessment Clinic, data were collected on 497 women regarding their injury assessment for IPV reported to the Kaohsiung City Government. Results: Taiwanese survivors were older compared to immigrant survivors. Taiwanese survivors also had higher education levels compared to immigrant survivors. Taiwanese survivors had higher employment rate than immigrant survivors did. The time between IPV and medical help seeking was longer for divorced than married women. Conclusions: These results can facilitate understanding of the conditions and patterns of IPV in Taiwan, increase the awareness of nurses, especially the emergency nurses for the prevention of IPV, and increase professional competency for the provision of appropriate healthcare services to survivors of IPV. Copyright © 2015, Korean Society of Nursing Science. Published by Elsevier. All rights reserved.

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        Hyperpolarized Carbon-13 Magnetic Resonance Imaging: Technical Considerations and Clinical Applications

        Lai Ying-Chieh,Hsieh Ching-Yi,Juan Yu-Hsiang,Lu Kuan-Ying,Lee Hsien-Ju,Ng Shu-Hang,Wan Yung-Liang,Lin Gigin 대한영상의학회 2024 Korean Journal of Radiology Vol.25 No.5

        Hyperpolarized (HP) carbon-13 (13C) MRI represents an innovative approach for noninvasive, real-time assessment of dynamic metabolic flux, with potential integration into routine clinical MRI. The use of [1-13C]pyruvate as a probe and its conversion to [1-13C]lactate constitute an extensively explored metabolic pathway. This review comprehensively outlines the establishment of HP 13C-MRI, covering multidisciplinary team collaboration, hardware prerequisites, probe preparation, hyperpolarization techniques, imaging acquisition, and data analysis. This article discusses the clinical applications of HP 13C-MRI across various anatomical domains, including the brain, heart, skeletal muscle, breast, liver, kidney, pancreas, and prostate. Each section highlights the specific applications and findings pertinent to these regions, emphasizing the potential versatility of HP 13C-MRI in diverse clinical contexts. This review serves as a comprehensive update, bridging technical aspects with clinical applications and offering insights into the ongoing advancements in HP 13C-MRI.

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